"The weapons (Moscow) has sold to Iran have never been used against any other country," Lavrov said in an interview with Russian news network Russia Today on Friday.
Lavrov reiterated that Georgia, unlike Iran, has used Russian-made weapons "to kill Russians, to kill civilians, including Russian peacekeepers who are serving under the international agreement signed by Georgia".
Lavrov further stressed that Russia sells exclusively defensive systems to Tehran and said that there is no room for Western concern.
In recent months, Israel and the US have sought to pressure the Kremlin to halt the delivery of the S-300 system, which according to Western experts could effectively rule out the possibility of any Israeli strike on Iranian nuclear facilities until Tel Aviv acquires the advance US fighter jet, F-22.
"Whatever we sell to Iran or to any other country is not covered by any prohibitions internationally or nationally. In the Russian Federation, we have one of the strictest export control legislations. And whatever we sell to Iran in particular is only of defensive nature," Lavrov added.
Earlier on Thursday, Lavrov reiterated that Iran-Russia military and technical cooperation are in accordance with the international and Russian regulations.
"All our actions in the sphere of military technical cooperation with Iran are absolutely legal," Lavrov made the remark answering questions of an audience at the Carnegie Endowment for International Peace.