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News number: 8805050792

14:26 | 2009-07-27

Science

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BP-DBS May Treat Patients with Dystonia-Choreoathetosis CP

TEHRAN (FNA)- Findings of a new study revealed that bilateral pallidal neurostimulation could be an effective treatment option for patients with dystonia-choreoathetosis CP.



Cerebral palsy (CP) with dystonia-choreoathetosis is a common cause of disability in children and in adults, and responds poorly to medical treatment. Bilateral pallidal deep brain stimulation (BP-DBS) of the globus pallidus internus (GPi) is an effective treatment for primary dystonia, but the effect of this reversible surgical procedure on dystonia-choreoathetosis CP, which is a subtype of secondary dystonia, is unknown. Our aim was to test the effectiveness of BP-DBS in adults with dystonia-choreoathetosis CP.

In this study published in the Lancet Journal, the researchers did a multicentre prospective pilot study of BP-DBS in 13 adults with dystonia-choreoathetosis CP who had no cognitive impairment, little spasticity, and only slight abnormalities of the basal ganglia on MRI.

The primary endpoint was changed in the severity of dystonia-choreoathetosis after 1 year of neurostimulation, as assessed with the Burke-Fahn-Marsden dystonia rating scale. The accuracy of surgical targeting to the GPi was assessed masked to the results of neurostimulation. Analysis was by intention to treat.

The mean Burke-Fahn-Marsden dystonia rating scale movement score improved from 44·2 (SD 21·1) before surgery to 34·7 (21·9) at 1 year post-operatively (p=0·009; mean improvement 24·4 [21·1]%, 95% CI 11·6-37·1).

Functional disability, pain, and mental health-related quality of life were significantly improved.

There was no worsening of cognition or mood. Adverse events were related to stimulation (arrest of the stimulator in one patient, and an adjustment to the current intensity in four patients).

The optimum therapeutic target was the posterolateroventral region of the GPi. Little improvement was seen when the neurostimulation diffused to adjacent structures (mainly to the globus pallidus externus [GPe]).

Bilateral pallidal neurostimulation could be an effective treatment option for patients with dystonia-choreoathetosis CP; however, given the heterogeneity of motor outcomes and the small sample size, results should be interpreted with caution.

The optimum placement of the leads seemed to be a crucial, but not exclusive, factor that could affect a good outcome.