Vahidi warned of foreign plots to fuel insecurity in the Persian Gulf, and that the Islamic Republic will not allow the regional security to be undermined.
"Iran's Armed Forces will not permit foreign troops to undermine security and peace in the Persian Gulf region," Vahidi said on Wednesday.
"US-Zionist plots such as [a plan to deploy] a missile shield system in the Persian Gulf will damage security in the region and provide security for the illegitimate Zionist regime (Israel)," he added.
US officials have frequently said it is a US "priority" to help the Persian Gulf littoral states build "regional missile defense architecture."
The Iranian defense minister emphasized that security of the Persian Gulf should solely be maintained by regional countries.
Vahidi had also on Wednesday warned that the US-Israeli project for deploying a missile shield in the Persian Gulf impairs security of the region, reiterating that the battery merely serves the security of the Zionist regime.
"The US-Israeli plans like the missile defense shield in the Persian Gulf impairs security of the region and is in line with establishing security of the Zionist regime," Vahidi said, addressing a number of commanders and forces of the Islamic Revolution Guards Corps (IRGC) in the Southern province of Hormozgan.
US Secretary of State Hillary Clinton last week promoted the missile shield idea at a Persian Gulf-US security forum in Riyadh, Saudi Arabia. US officials have said it is their "priority" to help the six Persian Gulf Cooperation Council (PGCC) states build "regional missile defense architecture" against Iran.
Washington has been seeking hard to portray Iran as a threat to the regional states, specially the Arab countries on the rims of the Persian Gulf, but many Arab leaders in the region stress that they do not see Iran as a threat.