The explosions struck the al-Mahdi street in Abu Rumaneh district of the Syrian capital, wounding four people, the al-Donya TV said.
Government officials say the explosion appeared to target a building under construction near the offices of the joint chief of staff. The building, which was empty at the time of the blast, is a base for army officers who guard the joint chief of staff offices, which are located some 200 meters (yards) away.
Syria has been experiencing unrest since March 2011 with organized attacks by well-armed gangs against Syrian police forces and border guards being reported across the country.
Hundreds of people, including members of the security forces, have been killed, when some protest rallies turned into armed clashes.
The government blames outlaws, saboteurs, and armed terrorist groups for the deaths, stressing that the unrest is being orchestrated from abroad.
In October 2011, calm was eventually restored in the Arab state after President Assad started a reform initiative in the country, but Israel, the US and its Arab allies are seeking hard to bring the country into chaos through any possible means. Tel Aviv, Washington and some Arab capitals have been staging various plots in the hope of increasing unrests in Syria.