Salehi made the remarks addressing the 'Muslim Ulema (religious scholars) and Islamic Awakening' conference in Tehran on Tuesday.
"What is currently going on in Syria as an important country in the region is a threat which would pose a serious challenge to tranquility and security of the entire region," the Iranian foreign minister said.
He noted that the solution to the Syrian crisis is merely political, and warned that any move against that direction would further complicate the situation.
"Since the very beginning of the crisis in Syria, the Islamic Republic of Iran called for an end to the conflict and the restoration of calm in this country, and supported democracy and increased people's role in political and social decision-making," Salehi added.
The two-day conference of 'Muslim Ulema (religious scholars) and Islamic Awakening' was attended by over 500 Iranian and 200 foreign scholars.
Syria has been experiencing unrest since March 2011 with organized attacks by well-armed gangs against Syrian police forces and border guards being reported across the country.
The US and its western and regional allies have long sought to topple Syrian President Bashar al-Assad and his ruling system. Media reports said that the Syrian rebels and terrorist groups have received significantly more and better weapons in recent weeks, a crime paid for by the Persian Gulf Arab states and coordinated by the United States.
The US daily, Washington Post, reported in May that the Syrian rebels and terrorist groups battling Assad's government have received significantly more and better weapons in recent weeks, a crime paid for by the Persian Gulf Arab states and coordinated by the United States.
The newspaper, quoting opposition activists and US and foreign officials, reported that Obama administration officials emphasized the administration has expanded contacts with opposition military forces to provide the Persian Gulf nations with assessments of rebel credibility and command-and-control infrastructure.
Opposition activists who several months ago said the rebels were running out of ammunition said in May that the flow of weapons - most bought on the black market in neighboring countries or from elements of the Syrian military in the past - has significantly increased after a decision by Saudi Arabia, Qatar and other Persian Gulf states to provide millions of dollars in funding each month.