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Heart condition’s signaling-pathway defect
The beta adrenergic pathway is dysfunctional in dilated cardiomyopathy. Now, researchers have learned how a mutation that causes the disease affects the pathway, and how to mitigate its effects.
To graduates: Use science to change the world
At the medical school’s commencement, Lucy Shapiro described how years of solitary work in the laboratory led her to influence public policy and battle the growing threat of infectious disease on the global stage.
Leading in Precision Health
A Legacy of Innovation
First synthesis of biologically active DNA in test tube
Nobel laureate Arthur Kornberg creates a strand of biologically active DNA, paving the way for studies of genetics.
First adult human heart transplant in the United States
Norman Shumway successfully transplants a heart into 54-year-old steelworker Mike Kasperak, who survives for 14 days.
First expression of a foreign gene implanted in bacteria by recombinant DNA methods
Geneticist Stanely Cohen transfers a foreign gene into bacterial cells, which then express the gene.
First successful human combined heart/lung transplant in the world (fourth attempted worldwide)
Mary Gohlke receives the world's first combined heart and lung transplant in a landmark operation led by surgeon Bruce Reitz.
Isolation of pure hematopoietic stem cells from mice
Pathologist Irving Weissman isolates a rare mouse cell, known as the hematopoetic stem cell, which gives rise to all the cells of the blood and immune systems.
First use of gene expression profiling to predict cancer outcomes
Application and expansion of optogenetics, a technique to control brain cell activity with light
Bioengineer Karl Deisseroth and his team develop a technique known as optogenetics that allows them to genetically alter brain cell activity in mice with light.