Publications by Research Area

New Reactions Development
Total Synthesis of Complex Molecules
New Drug Delivery Systems
Drug Design, Synthesis, and Biological Evaluation
Protein Kinase C, Tumor Promotors, and Synthetic Receptors
Other Items and Group History

Representative Publications

  • Wender, Paul A.; Fournogerakis, Dennis N.; Jeffreys, Matthew S.; Quiroz, Ryan V.; Inagaki, Fuyuhiko; Pfaffenbach, Magnus; "Structural Complexity Through Multicomponent Cycloaddition Cascades Enabled by Dual-Purpose, Reactivity Regenerating 1,2,3-Triene Equivalents", Nature Chemistry, 2014, 6, 448-452. Abstract, PDF.

  • Wender, P.A.; Donnelly, A.C.; Loy, B.A.; Near, K.E.; Staveness, D., “Rethinking the Role of Natural Products: Function-Oriented Synthesis, Bryostatin and Bryologs;Natural Products in Medicinal Chemistry (Ed: S. Hanessian) Wiley-VCH, 2014, Ch. 14, 475-544. PDF.

  • Daniel C. Buehler, Matthew D. Marsden, Sean Shen, Daniel B. Toso, Xiaomeng Wu, Joseph A. Loo, Z. Hong Zhou, Valerie A. Kickhoefer, Paul A. Wender, Jerome A. Zack, and Leonard H. Rome, "Bioengineered vaults: Self-assembling protein shell-lipophilic core nanopartiles for drug delivery", ACS Nano., 2014, 8(8), 7723-7732.  Abstract, PDF

  • Vargas, Jessica R.; Geihe Stanzl, Erika; Teng, Nelson N.H.; Wender, Paul A.; "Cell-penetrating, Guanidinium-rich Molecular Transporters for Overcoming Efflux-mediated Multidrug Resistance", Molecular Pharmaceutics, 2014, 11(8), 2553-2565.  Abstract, PDF

  • Erika Geihe Stanzl, Brian M. Trantow, Jessica R. Vargas, Paul A. Wender, "15 Years of Cell-Penetrating, Guanidinium-rich Molecular Transporters: Basic Science, Research Tools and Clinical Applications", Accounts, 2013, 46(12), 2944-2954. Abstract, PDF.

  • Wender, Paul A. "Toward the Ideal Synthesis and Transformative Therapies: The Roles of Step Economy and Function Oriented Synthesis", Tetrahedron, 2013, Vol. 69, Issue 36, 7529-7550. Abstract.

  • Elizabeth J. Beans, Dennis Fournogerakis, Carolyn Gauntlett, Lars V. Heumann, Rainer Kramer, Matthew D. Marsden, Danielle Murray, Tae-Wook Chun, Jerome A. Zack, and Paul A. Wender, "Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo", PNAS, 2013, 110(29), 11698-11703. Abstract, PDF.

  • Brian A. DeChristopher, Brian A. Loy, Matthew D. Marsden, Adam J. Schrier, Jerome A. Zack, & Paul A. Wender, “Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro”, Nature Chemistry, 2012, 4, 705-710. Full Text.

  • Xiufang Xu, Peng Liu, Adam Lesser, Lauren E. Sirois, Paul A. Wender, and K.N. Houk, "Ligand Effects on Rates and Regioslectivities of Rh(I)-Catalyzed (%+2) Cycloadditions: A Computational Study of Cyclooctadiende and Dinaphthocyclooctatetraene as Ligands", J. Am. Chem. Soc. 2012, 134(26), pp. 11012-11025. Abstract, PDF, Supporting Information.

  • Erika I. Geihe, Christina B. Cooley, Jeff R. Simon, Matthew K. Kiesewetter, Justin A. Edward, Robyn P. Hickerson, Roger L. Kaspar, James L. Hedrick, Robert M. Waymouth, & Paul A. Wender, “Designed guanidinium-rich amphipathic oligocarbonate molecular transporters complex, deliver and release siRNA in cells”, PNAS, 2012, 109 (33), 13171-13176. Abstract, PDF, Supporting Information.

  • Paul Wender & Adam Schrier; "Total Synthesis of Bryostatin 9", Journal of the American Chemical Society, 2011, 133(24), 9228-9231. Abstract, PDF.

  • Wender, Paul A.; Miller, Benjamin L.; "Synthesis at the Molecular Frontier", Nature, 2009, 460, 197-201. Abstract, PDF.

  • Paul A. Wender, Jung-Min Kee, and Jeffrey M. Warrington, "Practical Synthesis of Prostratin, DPP, and their Analog, Adjuvant Against Latent HIV", Science, 2008, 320, 649-652. Abstract, HTML, Supporting Information.