Total Synthesis of Complex Molecules
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  • Wender, P.A.; "Toward the Ideal Synthesis and and Transformative Therapies: The Roles of Step Economy and Function Oriented Synthesis"; Tetrahedron, 2013, 69(36), pp. 7529-7550. Article.
  • Yasuyuki Ogawa, Phillip P. Painter, Dean J. Tantillo, and Paul A. Wender; "Mechanistic and Computational Studies of Exocyclic Stereocontrol in the Synthesis of Bryostatin-like Cis-2, 6-Disubstituted 4-Alkylidenetetrahydropyrans by Prins Cyclization"; J. Org. Chem., 2013, 78(1), pp. 104-115.Abstract, PDF, Supporting Information
  • Wender, Paul A. & Reuber, Jenny; "Function Oriented Synthesis: Preparation and Initial Biological Evaluation of New A-Ring-Modified Bryologs",Tetrahedron, 2011, 67, 9998-10005. Abstract, PDF.
  • Paul Wender & Adam Schrier; "Total Synthesis of Bryostatin 9", Journal of the American Chemical Society, 2011, 133(24), 9228-9231. Abstract,PDF.
  • Wender, Paul A.; Buschmann, Nicole; Cardin, Nathan B.; Jones, Lisa R.; Kan, Cindy; Kee, Jung-Min; Kowalski, John A.; Longcore, Kate E., “Gateway Synthesis of Daphnane Congeners and Their PKC Affinities and Cell-Growth Activities”, Nature Chemistry, 2011, 3, 615-619. Abstract
  • Adam Schrier, Brian Loy, and Paul A. Wender, “Translating Nature’s Library: the Bryostatins and Function-Oriented Synthesis” Israel J. Chem.,2011, 51, 453-472.
  • Wender, P. A.; D'Angelo, N.; Elitzin, V. I.; Ernst, M.; Jackson-Ugueto, E. E.; Kowalski, J. A.; McKendry, S.; Rehfeuter, M.; Sun, R.; Voigtlaender, D. "Function-Oriented Synthesis: Studies Aimed at the Synthesis and Mode of Action of 1a-Alkyldaphnane Analogues" Org. Lett., 2007, 9, 1829-1832. Abstract, PDF, Supporting Information
  • Wender, P. A.; Bi, F. C.; Buschmann, N.; Gosselin, F.; Kan, C.; Kee, J.-M.; Ohmura, H. "Studies on Oxidopyrylium [5 + 2] Cycloadditions: Toward a General Synthetic Route to the C12-Hydroxy Daphnetoxins" Org. Lett., 2006, 8, 5373-5376. Abstract, PDF, Supporting Information
  • Wender, P. A.; Koehler, M. F. T.; Sendzik, M. "A New Synthetic Approach to the C Ring of Known as Well as Novel Bryostatin Analogues" Org. Lett., 2003, 5, 4549-4552. Abstract, PDF, Supporting Information
  • Wender, P. A.; Hegde, S. G.; Hubbard, R. D.; Zhang, L.; Mooberry, S. L. "Synthesis and Biological Evaluation of (-)-Laulimalide Analogues" Org. Lett., 2003, 5, 3507-3509. Abstract, PDF, Supporting Information
  • Wender, P. A.; Baryza, J. L.; Brenner, S. E.; Clarke, M. O.; Gamber, G. G.; Horan, J. C.; Jessop, T. C.; Kan, C.; Pattabiraman, K.; Williams, T. J. "Inspirations from Nature. New Reactions, New Therapeutic Leads, and New Drug Delivery Systems" Pure Appl. Chem., 2003, 75, 143-156.Abstract, PDF
  • Wender, P. A.; Hegde, S. G.; Hubbard, R. D.; Zhang, L. "Total Synthesis of (-)-Laulimilide" J. Am. Chem. Soc., 2002, 124, 4956-4967. Abstract,PDF, Supporting Information
  • Wender, P. A.; Bi, F. C.; Brodney, M. A.; Gosselin, F. "Asymmetric Synthesis of the Tricyclic Core of NGF-inducing Cyathane Diterpenes via a Transition-Metal-Catalyzed [5+2] Cycloaddition" Org. Lett. 2001, 3, 2105-2108. Abstract, PDF, Supporting Information
  • Wender, P. A.; Zhang L. "Asymmetric Total Synthesis of (+)-Aphanamol I Based on the Transition Metal Catalyzed [5+2] Cycloaddition of Allenes and Vinylcyclopropanes Org. Lett. 2000, 2, 2323-2326. Abstract, PDF, Supporting Information
  • Wender, P. A.; Hinkle K. W. "Synthesis and Biological Evaluation of A New Class of Bryostatin Analogues: the Role of the C20 Substituent in Protein Kinase C Binding" Tetrahedon Lett. 2000, 41, 6725-6729. PDF
  • Wender, P. A.; Lippa B. "Synthesis and Biological Evaluation of Bryostatin Analogues: the Role of the A-Ring" Tetrahedon Lett. 2000, 41, 1007-1011. PDF
  • Wender, P. A.; Fuji, M; Husfeld, C. O.; Love, J. A. "Rhodium-Catalyzed [5+2] Cycloadditions of Allenes and Vinylcyclopropanes: Asymmetric Total Synthesis of (+)-Dictamnol" Org. Lett. 1999, 1, 137-139. Abstract, PDF, Supporting Information
  • Wender, P. A.; Hinkle, K. W.; Koehler, M. F. T.; Lippa, B. "The Rational Design of Potential Chemotherapeutic Agents: Synthesis of Bryostatin Analogues" Med. Res. Rev. 1999, 19, 388-407. Abstract, PDF
  • Wender, P. A.; Debrabander, J.; Harran, P. G.; Jimenez, J. M.; Koehler, M. F. T.; Lippa, B.; Park, C. M.; Shiozaki, M."Synthesis of the First Members of A New Class of Biologically Active Bryostatin Analogues" J. Am. Chem. Soc. 1998, 120, 4534-4535. PDF, Supporting Information
  • Wender, P. A.; Dore T. M. "A Formal Synthesis of Crinipellin B Based on the Arene-Alkene Meta-Photocycloaddition Reaction" Tetrahedon Lett.1998, 39, 8589-8592. Abstract, PDF
  • Wender, P. A.; Handy S. T., Wright D. L. "Towards the Ideal Synthesis" Chemistry & Industry 1997, 765.
  • Wender, P. A.; Badham, N. F.; Conway, S. P.; Floreancig, P. E.; Glass, T. E.; Houze, J. B.; Krauss, N. .E; Lee, D. S.; Marquess, D. G.; Mcgrane, P. L.; Meng, W. "The Pinene Path To Taxanes. 6. A Concise Stereocontrolled Synthesis of Taxol" J. Am. Chem. Soc. 1997, 119, 2757-2758. PDF,Supporting Information
  • Wender, P. A.; Rice K. D., Schnute M. E. "The First Formal Asymmetric Synthesis of Phorbol" J. Am. Chem. Soc. 1997, 119, 7897-7898. PDF,Supporting Information
  • Wender, P. A.; Jesudason, C. D.; Nakahira, H.; Tamura, N.; Tebbe, A. L., Ueno, Y. "The First Synthesis of a Daphnane Diterpene: the Enantiocontrolled Total Synthesis of (+)-Resiniferatoxin" J. Am. Chem. Soc. 1997, 119, 12976-12977. PDF, Supporting Information
  • Wender, P. A.; Nuss, J. M.; Smith, D. B.; Suarezsobrino, A.; Vagberg, J.; Decosta, D.; Bordner, J. "Transition Metal Catalyzed Cycloadditions: An Intramolecular [4+4] Cycloaddition Strategy for the Efficient Synthesis of Dicyclopenta[A,D]Cyclooctene 5-8-5 Ring Systems" J. Org. Chem. 1997,62, 4908-4909. PDF, Supporting Information
  • Wender, P. A.; Badham, N. F.; Conway, S. P.; Floreancig, P. E.; Glass T. E.; Granicher, C.; Houze, J. B.; Janichen, J.; Lee, D. S.; Marquess, D. G. "The Pinene Path to Taxanes. 5. Stereocontrolled Synthesis of a Versatile Taxane Precursor" J. Am. Chem. Soc. 1997, 119, 2755-2756. PDF,Supporting Information
  • Wender, P. A.; Dore, T. M.; deLong, M. A. "An Arene-Alkene Photocycloaddition-Radical Cyclization Cascade: the First Syntheses of Cis,Cis,Cis,Trans-[5.5.5.5]-Fenestranes" Tetrahedon Lett. 1996, 37, 7687-7690. Abstract, PDF
  • Wender, P. A.; Smith, T. E. "Transition Metal-Catalyzed Intramolecular [4+2] Cycloadditions: A Novel Method for the Assembly of Nitrogen Heterocycles and its Application to Yohimban Alkaloid Synthesis"J. Org. Chem. 1996, 61, 824-825. PDF, Supporting Information
  • Wender, P. A.; Smith T. E."Transition Metal-Catalyzed Intramolecular [4+2] Cycloadditions: Initial Studies on Stereochemistry and on Steroid and Vitamin-D Analog Syntheses" J. Org. Chem. 1995, 60, 2962-2963. PDF
  • Wender, P. A.; Beckham, S.; Oleary, J. G. "A 2nd-Generation Photochemically Activatable Dynemicin Analog: A Concise Synthesis and DNA Cleavage Studies" Synthesis-Stuttgart 1994, 1278-1282.
  • Wender, P. A.; Natchus, M. G.; Shuker, A. J. "Towards the Total Synthesis of Taxol and its Analogs," in Taxol, Science and Applications; Matthew Suffness, Ed.; CRC Press, Inc, London; Pp. 123-187, 1995.
  • Wender, P. A.; Mucciaro, T. P. "A New and Practical Approach to the Synthesis of Taxol and Taxol Analogs: The Pinene Path" J. Am. Chem. Soc.1992, 114, 5878-5879. PDF
  • Wender, P. A.; deLong, M. A. "Synthetic Studies on Arene-Olefin Cycloadditions. XII. Total Synthesis of (+/-)-Subergorgic Acid" Tetrahedon Lett.1990, 31, 5429-5432. Abstract, PDF
  • Wender, P. A.; Singh, S. K. "Synthetic Studies on Arene-Olefin Cycloadditions. 11. Total Synthesis of (-)-Retigeranic Acid" Tetrahedon Lett. 1990,31, 2517-2520. Abstract, PDF
  • Wender, P. A.; Ternansky, R; deLong, M; Singh, S; Olivero, A; Rice, K. "Arene Alkene Cycloadditions and Organic-Synthesis" Pure Appl. Chem.1990, 62, 1597-1602.
  • Wender, P. A.; McDonald, F. E. "Studies on Tumor Promoters. 9. A 2nd-Generation Synthesis of Phorbol" J. Am. Chem. Soc. 1990, 112, 4956-4958.PDF
  • Wender, P. A.; Siggel, L.; Nuss, J. M. "Arene-Alkene Photocycloaddition Reaction," Org. Photochem. 10, 357, 1989.
  • Wender, P. A.; Kogen, H.; Lee, H. Y.; Munger, J. D.; Wilhelm, R. S.; Williams, P. D. "Studies on Tumor Promoters. 8. the Synthesis of Phorbol" J. Am. Chem. Soc. 1989, 111, 8957-8958. PDF
  • Wender, P. A.; Ihle, N. C.; Correia C. R. D. "Nickel-Catalyzed Intramolecular [4+4] Cyclo-Additions. 4. Enantioselective Total Synthesis of (+)-Asteriscanolide" J. Am. Chem. Soc. 1988, 110, 5904-5906. PDF
  • Wender, P. A.; Vongeldern, T. W.; Levine, B. H. "Synthetic Studies on Arene Olefin Cyclo-Additions. 10. A Concise, Stereocontrolled Total Synthesis of (+/-)-Laurenene" J. Am. Chem. Soc. 1988, 110, 4858-4860. PDF
  • Wender, P. A.; Harmata, M.; Jeffrey, D.; Mukai, C.; Suffert, J. "Studies on DNA-Active Agents: the Synthesis of the Parent Carbocyclic Subunit of Neocarzinostatin Chromophore-A" Tetrahedon Lett. 1988, 29, 909-912.
  • Wender, P. A.; Schaus, J. M., White, A. W."General Methodology for cis-Hydroisoquinoline Synthesis .3. A Sixteen Step Synthesis of Reserpine"Heterocycles 1987, 25, 263-270.
  • Wender, P. A.; Fisher, K. "The Total Synthesis of (+/-)-Rudmollin .9. 7-Membered Ring Synthesis Based on Arene Olefin Cycloadditions"Tetrahedon Lett. 1986, 27, 1857-1860.
  • Wender, P. A.; Singh, S. K. "Synthetic Studies on Arene-Olefin Cyclo-Additions .8. Total Syntheses of (+/-)-Silphiperfol-6-Ene, (+/-)-7-Alpha-H-Silphiperfol-5-Ene and (+/-)-7-Beta-H-Silphiperfol-5-Ene" Tetrahedon Lett. 1985, 26, 5987-5990.
  • Wender, P. A.; Holt, D. A. "Macroexpansion Methodology .3. 8-Step Synthesis of (-)-(3Z)-Cembrene-A" J. Am. Chem. Soc. 1985, 107, 7771-7772.PDF
  • Wender, P. A.; Wolanin, D. J. "Total Synthesis of Quadrone and Terrecyclic Acid-A" J. Org. Chem. 1985, 50, 4418-4420. PDF
  • Wender, P. A.; Ternansky R. J. "Synthetic Studies on Arene-Olefin Cyclo-Additions .7. A 3-Step Total Synthesis of (+/-)-Silphinene" Tetrahedon Lett. 1985, 26, 2625-2628.
  • Wender, P. A.; Howbert, J. J. "Synthetic Studies on Areneolefin Cyclo-Additions .6. 2 Syntheses of (+/-)-Coriolin" Tetrahedon Lett. 1983, 24, 5325-5328.
  • Wender, P. A.; Dreyer, G. B. "Synthetic Studies on Arene-Olefin Cyclo-Additions .5. Total Synthesis of (+/-)-Isoiridomyrmecin" Tetrahedon Lett.1983, 24, 4543-4546.
  • Wender, P. A.; Dreyer, G. B."Synthetic Studies on Arene-Olefin Cyclo-Additions .4. Total Synthesis of (+/-)-Modhephene" J. Am. Chem. Soc. 1982,104, 5805-5807. PDF
  • Wender, P. A.; Howbert, J. J. "Synthetic Studies on Arene-Olefin Cyclo-Additions .3. Total Synthesis of +/-Hirsutene" Tetrahedon Lett. 1982, 23, 3983-3986.
  • Wender, P. A.; Eck, S. L."The Olefin Metathesis Trans-Annular Ene Sequence: A Method for the Stereocontrolled Synthesis of Trans-Decalin Derivatives .3. Total Synthesis of (+/-)-Warburganal" Tetrahedon Lett. 1982, 23, 1871-1874.
  • Wender, P. A.; Dreyer, G. B. "Synthetic Studies on Arene-Olefin Cyclo-Additions .2. Total Synthesis of (+/-)-Isocomene" Tetrahedron 1981, 37, 4445-4450.
  • Wender, P. A.; Howbert, J. J. "Synthetic Studies on Arene-Olefin Cyclo-Additions: Total Synthesis of (-/+)-Alpha-Cedrene" J. Am. Chem. Soc. 1981,103, 688-690. PDF
  • Wender, P. A.; Lechleiter, J. C. "Total Synthesis of (+/-) Isabelin" J. Am. Chem. Soc. 1980, 102, 6340-6341. PDF
  • Wender, P. A.; Schaus, J. M.; White, A. W. "General Methodology for cis-Hydroisoquinoline Synthesis: Synthesis of Reserpine" J. Am. Chem. Soc.1980, 102, 6157-6159. PDF
  • Wender, P. A.; Letendre, L. J. "Olefin Metathesis Trans-Annular Ene Sequence: Method for the Stereocontrolled Synthesis of Trans-Decalin Derivatives .2. Formal Eudesmane Syntheses" J. Org. Chem. 1980, 45, 367-368. PDF
  • Wender, P. A.; Hubbs, J. C. "Olefin Metathesis Trans-Annular Ene Sequence: Method for the Stereocontrolled Synthesis of Trans-Decalin Derivatives .1. Total Synthesis of (+/-)-Calameon" J. Org. Chem. 1980, 45, 365-367. PDF
  • Wender, P. A.; Eissenstat, M. A.; Filosa, M. P. "General Methodology for Pseudoguaiane Synthesis: Total Synthesis of (+/-)-Damsinic Acid and (+/-)-Confertin" J. Am. Chem. Soc. 1979, 101, 2196-2198. PDF
  • Wender, P. A.; Lechleiter, J. C. "Photochemically Mediated [4c+2c] Annelation: Synthesis of (+/-)-10-Epijunenol" J. Am. Chem. Soc. 1978, 100, 4321-4322. PDF