Protein Kinase C, Tumor Promotors, and Synthetic Receptors
Previous   Next

  • Stang, Stacey L.; Lopez-Campistrous, Ana; Song, Xiaohua; Dower, Nancy A.; Blumberg, Peter M.; Wender, Paul A.; Stone, Jim “ A Pro-apoptotic Signaling Pathway involving RasGRP, Erk and Bim in B Cells” Experimental Hematology, 2009, 37, 122-134. Abstract.
  • Shaha, S.P.; Tomic, J.; Shi, Y.; Pham, T.; Mero, P.; White, D.; He, L.; Baryza, J.L.; Wender, P.A.; Booth, J.W.; Spaner, D.E.; "Prolonging Microtubule Dysruption Enhances the Immunogenicity of Chronic Lymphocytic Leukemia Cells", Clinical & Experimental Immunolocy, 2009, 158, 186-198. Abstract, PDF.
  • Tapan Kumar Khan; Thomas J Nelson; Vishal A Verma; Paul A Wender; Daniel L Alkon: “A Cellular Model of Alzheimer’s Disease Therapeutic Efficacy: PKC Activation Reverses A-beta induced biomarker Abnormality on Cultured Fibroblasts” Neurobiology of Disease 2009, 34(2), 332-339.Abstract, PDF.
  • Statsuk, Alexander V.; Bai, Ruoli; Baryza, Jeremy L.; Verma, Vishal A.; Hamel, Ernest; Wender, Paul A.; Kozmin, Sergey A. "Actin is the primary cellular receptor of bistramide A" Nature Chemical Biology, 2005, 1, 383-388. PDF, Supporting Information
  • Hammond, C.; Shi, Y. H.; Mena, J.; Tomic, J.; Cervi, D.; He, L. W.; Millar, A. E.; DeBenedette, M.; Schuh, A. C.; Baryza, J. L.; et. al. "Effect of Serum and Antioxidants on the Immunogenicity of Protein Kinase C-activated Chronic Lymphocytic Leukemia Cells" J. Immunotherapy 2005, 28, 28-39. Abstract, PDF,.
  • Stone, J. C.; Stang, S. L.; Zheng, Y.; Dower, N. A.; Brenner, S. E.; Baryza, J. L.; Wender, P. A. "Synthetic Bryostatin Analogues Activate the RasGRP1 Signaling Pathway" J. Med. Chem. 2004, 47, 6638-6644. Abstract, PDF.
  • Baryza, J. L.; Brenner, S. E.; Craske, M. L.; Meyer, T.; Wender, P. A. "Simplified Analogs of Bryostatin with Anticancer Activity Display Greater Potency for Translocation of PKC delta-GFP" Chem. Bio. 2004, 11, 1261-1267.
  • Chen, L; Wright, L. R.; Chen, C. H.; Oliver, S. F.; Wender, P. A.; Mochly-Rosen D. "Molecular Transporters for Peptides: Delivery of a Cardioprotective Epsilon PKC Agonist Peptide into Cells and Intact Ischemic Heart Using a Transport System, R-7" Chemistry & Biology 2001, 8, 1123-1129. Abstract, PDF
  • Shindo, M.; Irie, K.; Nakahara, A,; Ohigashi, H,; Konishi, H.; Kikkawa, U.; Fukuda, H.; Wender, P. A. "Toward the Identification of Selective Modulators of Protein Kinase C (PKC) Isozymes: Establishment of A Binding Assay for PKC Isozymes Using Synthetic C1 Peptide Receptors and Identification of the Critical Residues Involved in the Phorbol Ester Binding" Bioorg. Med. Chem. 2001, 9, 2073-2081. Abstract
  • Tanaka M, Irie K, Nakagawa Y, Nakamura Y, Ohigashi H, Wender, P. A."The C4 Hydroxyl Group of Phorbol Esters is not Necessary for Protein Kinase C Binding" Bioorg. Med. Chem. Lett. 2001, 11, 719-722. Abstract
  • Nakagawa, Y.; Irie, K.; Ohigashi, H.; Hayashi, H.; Wender, P. A."Synthesis and PKC Isozyme Surrogate Binding of indothiolactam-V, A New Thioamide Analogue of Tumor Promoting indolactam-V" Bioorg. Med. Chem. Lett. 2000, 10, 2087-2090. Abstract
  • Wender, P. A.; Hinkle K. W. "Synthesis and Biological Evaluation of A New Class of Bryostatin Analogues: the Role of the C20 Substituent in Protein Kinase C Binding" Tetrahedon Lett. 2000, 41, 6725-6729. Abstract
  • Fukuda, H,; Irie, K,; Nakahara, A.; Ohigashi, H.; Wender, P. A. "Solid-Phase Synthesis, Mass Spectrometric Analysis of the Zinc-Folding, and Phorbol Ester-Binding Studies of the 116-Mer Peptide Containing the Tandem Cysteine-Rich C1 Domains of Protein Kinase C Gamma" Bioorg. Med. Chem. 1999, 7, 1213-1221.
  • Wender, P. A.; Kirschberg, T. A.; Williams, P. D.; Bastiaans, H. M. M.; Irie, K. "A New Class of Simplified Phorbol Ester Analogues: Synthesis and Binding To PKC and Eta PKC-C1b (Eta PKC-Cpd2)" Org. Lett. 1999, 1, 1009-1012. Abstract, PDF, Supporting Information,
  • Wender, P. A.; Koehler, M. F. T.; Wright, D. L.; Irie, K. "Mapping Phorbol Ester Binding Domains of Protein Kinase C (PKC): the Design, Synthesis and Biological Activity of Novel Phorbol Ester Dimers" Synthesis 1999, 1401-1406.
  • Irie, K.; Oie, K.; Nakahara, A.; Yanai, Y.; Ohigashi, H.; Fukuda, H.; Wender, P. A. "Synthesis and Phorbol Ester Binding of the Zinc-finger Like Sequences of All Protein Kinase C Isozymes, In Peptide Science 1998, M. Kondo, Ed.: Protein Research Foundation, Osaka , 65-68, 1999.
  • Wender, P. A.; Lippa, B.; Park, C. M.; Irie, K.; Nakahara, A.; Ohigashi, H. "Selective Binding of Bryostatin Analogues To the Cysteine Rich Domains of Protein Kinase C Isozymes" Bioorg. Med. Chem. Lett. 1999, 9, 1687-1690.
  • Fukuda, H.; Irie, K.; Nakahara, A.; Oie, K.; Ohigashi, H.; Wender, P. A. "Synthesis and Binding Studies of the 116-Mer Peptide Containing the Double Cysteine-Rich Motifs of Protein Kinase C Gamma" Tetrahedon Lett. 1998, 39, 7943-7946.
  • Wender, P. A.; Martincantalejo, Y.; Carpenter, A. J., Chiu, A.; Debrabander, J.; Harran, P. G.; Jimenez, J. M.; Koehler, M. F. T; Lippa, B."The Chemistry-Medicine Continuum: Synthetic, Computer, Spectroscopic and Biological Studies on New Chemotherapeutic Leads" Pure Appl. Chem.1998, 70, 539-546.
  • Irie, K.; Oie, K.; Nakahara, A.; Yanai, Y.; Ohigashi, H.; Wender, P. A.; Fukuda, H.; Konishi, H.; Kikkawa, U."Molecular Basis for Protein Kinase C Isozyme-Selective Binding: the Synthesis, Folding, and Phorbol Ester Binding of the Cysteine-Rich Domains of All Protein Kinase C Isozymes" J. Am. Chem. Soc. 1998, 120, 9159-9167. Abstract, PDF, Supporting Information,
  • Wender, P. A.; Debrabander, J; Harran P. G.; Jimenez J. M.; Koehler M. F. T.; Lippa, B; Park, C. M.; Siedenbiedel, C.; Pettit, G. R. "The Design, Computer Modeling, Solution Structure, and Biological Evaluation of Synthetic Analogs of Bryostatin 1" Proc. Natl. Acad. Sci. U. S. A. 1998, 95, 6624-6629. Abstract, PDF,
  • Irie, K.;Yanai, Y.; Ohigashi, H.; Wender, P. A. "Synthesis and Characterization of Model Peptides Incorporating the Phorbol Ester-binding Domain of Protein Kinase C," Peptide Chemistry 1996: C. Kitada (Ed.), Protein Research Foundation, Osaka, 209, 1997.
  • Yanai, Y.; Irie, K.; Ohigashi, H.; Wender, P. A. "Synthesis and Characterization of the First Cysteine-Rich Domain of Novel Protein Kinase C"Bioorg. Med. Chem. Lett. 1997, 7, 117-122.
  • Irie, K.; Yanai, Y.; Oie, K.; Ohigashi, H.; Wender, P. A. "Protein Kinase C Regulatory Domain Surrogate Peptides: Effects of Metal Ions on Folding, Phorbol Ester-Binding, and Selectivity" Bioorg. Med. Chem. Lett. 1997, 7, 965-970.
  • Irie, K.; Yanaim, Y.; Oie, K.; Ishizawa, J.; Nakagawa, Y.; Ohigashi, H.; Wender, P. A.; Kikkawa, U. "Comparison of Chemical Characteristics of the First and the Second Cysteine-Rich Domains of Protein Kinase C Gamma" Bioorg. Med. Chem. 1997, 5, 1725-1737.
  • Irie, K.; Isaka, T.; Iwata, Y.; Yanai, Y.; Nakamura, Y.; Koizumi, F.; Ohigashi, H.; Wender, P. A.; Satomi, Y.; Nishino, H. "Synthesis and Biological Activities of New Conformationally Restricted Analogues of (-)-Indolactam-V: Elucidation of the Biologically Active Conformation of the Tumor-Promoting Teleocidins" J. Am. Chem. Soc. 1996, 118, 10733-10743. Abstract, PDF, Supporting Information
  • Irie, K.; Yanai, Y.; Ohigashi, H.; Wender, P. A.; Miller, B. L."Synthesis and Characterization of the Second Cysteine-Rich Region of Mouse Skin PKC Eta" Bioorg. Med. Chem. Lett. 1996, 6, 353-356.
  • Irie, K.; Ishii, T.; Ohigashi, H.; Wender, P. A.; Miller B. L.; Takeda, N."Synthesis and Characterization of New Photolabile Phorbol Esters for Affinity Labeling of Protein Kinase C" J. Org. Chem. 1996, 61, 2164-2173. Abstract, PDF, Supporting Information
  • Wender, P. A.; Irie, K.; Miller, B. L."Identification, Activity, and Structural Studies of Peptides incorporating the Phorbol Ester-Binding Domain of Protein-Kinase-C" Proc. Natl. Acad. Sci. U. S. A. 1995, 92, 239-243. Abstract, PDF
  • Irie, K.; Koizumi, F.; Iwata, Y.; Ishii, T.; Yanai, Y.; Nakamura, Y.; Ohigashi, H.; Wender, P. A. "Synthesis and Biological-Activities of New Conformationally Fixed Analogs of (-)-indolactam-V, the Core Structure of Tumor-Promoting Teleocidins" Bioorg. Med. Chem. Lett. 1995, 5, 453-458.
  • Wender, P. A.; Irie, K.; Miller, B. L. "Synthesis and Binding of Photoaffinity Ligand Candidates for Protein-Kinase-C" J. Org. Chem. 1993, 58, 4179-4181.
  • Wender, P. A.; Cribbs, C. M. "Structural Design in Anti-tumor Compounds." In Molecular Mechanisms and Their Clinical Applications in Malignancies; Bergsagel, Daniel E. and Mak, Tak W., Eds.; Academic ; San Diego, CA, 215, 1991.
  • Wender, P. A.; Cribbs, C. M. "Computer Assisted Molecular Design Related to the Protein Kinase C Receptor," In Advances in Medicinal Chemistry; Maryanoff, C.A., Maryanoff, B.E., Eds.; JAI; Greenwich, CT; 1, 1-53, 1992.
  • Wender, P. A. "Chemsitry, Computers, and Carcinogenesis" Pure Appl. Chem., 1989, 61, 469.
  • Wender, P. A.; Koehler, K. F.; Sharkey, N. A.; Dellaquila, M. L.; Blumberg, P. M. "Analysis of the Phorbol Ester Pharmacophore on Protein-Kinase-C As a Guide To the Rational Design of New Classes of Analogs" Proc. Natl. Acad. Sci. U. S. A. 1986, 83, 4214-4218.
  • Wender, P. A.; Koehler, K.; Wilhelm, R.; Williams, P.; Keenan, R.; Lee, H. Y. "Tumor Promotion: Pharmacological and Synthetic Studies," in New Synthetic Methodology and Functionally Interesting Compounds, Z-I. Yoshida, Ed.; pp. 163-184, Elsevier Publishing Co., Amsterdam 1986.