Stylized cells depicting the metabolism and mechanism of action of mycophenolic acid. A fully interactive version is available at PharmGKB (http://www.pharmgkb.org/pathway/PA165964832). ABCB1, ATP-binding cassette, subfamily B (MDR/TAP), member 1; ABCC2, ATP-binding cassette, subfamily C (CFTR/MRP), member 2; Ac-MPAG, acyl glucuronide MPA; CES1, carboxylesterase 1; CES2, carboxylesterase 2; DM-MPA, 6-O-desmethyl-MPA; GI, gastrointestinal; GMP, guanosine monophosphate; IMP, inosine monophosphate; IMPDH1, inosine monophosphate dehydrogenase1; IMPHD2, inosine monophosphate dehydrogenase2; MMF, mycophenolate mofetil; MPA, mycophenolic acid; MPAG, MPA-7-O-glucuronide; SLCO1B1, solute carrier organic anion transporter family, member 1B1; SLCO1B3, solute carrier organic anion transporter family, member 1B3; XMP, xanthine monophosphate.