On the cover: Nakatani et al. (pp. 1235–1246) have generated a mouse model that recapitulates the most frequent chromosomal duplication found in people with autism. These mutant mice display altered behaviors, including poor social interaction, behavioral inflexibility, abnormal ultrasonic vocalizations, and correlates of anxiety, compared to wild-type mice. The artwork symbolizes a difference in the response to the world generated by the genomic duplication. The cover art was painted by Kishin Funada, a Japanese artist who specializes in oriental-style contemporary art.
Dorsal Closure in Drosophila Embryogenesis
In developing fly embryos, amnioserosa cells fill the gap between epidermal edges prior to dorsal closure. The amnioserosa cells pulse and tug on the epidermal cells before any closure is observed. An actin cable that forms at the boundary between amnioserosa cells and epidermis acts like a ratchet, leading to dorsal-ward movement of the epidermal front and eventual dorsal closure.
See also the paper by Solon et al.
SnapShots present up-to-date tables of nomenclature and glossaries, full signaling pathways, and schematic diagrams of cellular processes. Click here for a full list of SnapShots.
F Box Proteins II
Jeffrey R. Skaar, Julia K. Pagan, and Michele Pagano
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GABA Keeps up an Appetite for Life
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Damaged Gut Epithelium Calls in Stem Cell Support
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Actin’ like a Ratchet in Dorsal Closure
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For a complete table of contents, click here.
Evolution of Genetic Networks Underlying the Emergence of Thymopoiesis in Vertebrates
Baubak Bajoghli, Narges Aghaallaei, Isabell Hess, Immanuel Rode, Nikolai Netuschil, Boon-Hui Tay, Byrappa Venkatesh, Jr-Kai Yu, Stacy L. Kaltenbach, Nicholas D. Holland, Dagmar Diekhoff, Christiane Happe, Michael Schorpp, and Thomas Boehm
Mitochondrial Links to Genomic Instability in Aging
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A New Regulator of Asymmetric Cell Division in Plant Cells
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In this PaperClip, Dr. Fabiola Rivas speaks with Dr. Dominique Bergmann about the discovery of BASL, a new polarity factor in plant cells. You can listen directly by clicking on the player above. |
In this Review, Jennifer Phillips and Victor Corces examine the evidence that CTCF is a master regulator of higher-order chromatin architecture. CTCF: Master Weaver of the Genome
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In our June podcast, we hear from Dr. Brigid Hogan about a new study in Cell Stem Cell that reports on a stem cell population that can repair damaged lung tissue (start 1:04), and then we learn from Dr. Josh Mendell about his study in Cell showing that delivery of a microRNA to liver tumors in mice halts tumor growth (start 10:25). And stay tuned for a conversation with Dr. Gabriel Varani about his study in Chemistry & Biology reporting that RNA may be a useful drug target (start 18:41). You can listen directly by clicking on the player above. For a complete archive of Cell Press podcasts, click here. |
In this PaperClip, Dr. Connie Lee speaks with Dr. Allan Basbaum about his results on opioid receptor distribution and the implications for pain therapy. You can listen directly by clicking on the player above. For a complete list of Cell PaperClips, click here. |