We study the role of telomere shortening in the etiology of lethal cardiomyopathy in human iPS-derived cardiomyocytes and in cardiac tissues from patients
We elucidate the earliest transient regulators of reprogramming to pluripotency (iPS) and build regulatory networks using machine learning algorithms
We discover therapeutic agents that rejuvenate muscles and enhance regeneration in the aged
We are developing ways to extend telomeres transiently and safely to augment cell proliferative capacity and treat disease
We use diverse interdisciplinary approaches -- non-invasive bioluminescence imaging, timelapse genealogic lineage tracking, bioengineered niches, computational biology, single cell proteomics
We apply single-cell proteomic and genomic technologies to elucidate mechanisms governing muscle stem cell fate and regeneration