Fei-Fei Li
Associate Professor of Computer Science
Bio
Dr. Fei-Fei Li is an Associate Professor in the Computer Science Department at Stanford, and the Director of the Stanford Artificial Intelligence Lab and the Stanford Vision Lab. Her research areas are in machine learning, computer vision and cognitive and computational neuroscience, with an emphasis on Big Data analysis. Dr. Fei-Fei Li has published more than 100 scientific articles in top-tier journals and conferences, including Nature, PNAS, Journal of Neuroscience, CVPR, ICCV, NIPS, ECCV, IJCV, IEEE-PAMI, etc. Research from Fei-Fei's lab have been featured in New York Times, New Scientists and a number of popular press magazines and newspapers. Dr. Fei-Fei Li obtained her B.A. degree in physics from Princeton in 1999 with High Honors, and her PhD degree in electrical engineering from California Institute of Technology (Caltech) in 2005. She joined Stanford in 2009 as an assistant professor, and was promoted to associate professor with tenure in 2012. Prior to that, she was on faculty at Princeton University (2007-2009) and University of Illinois Urbana-Champaign (2005-2006). Dr. Fei-Fei Li is a recipient of the 2014 IBM Faculty Fellow Award, 2011 Alfred Sloan Faculty Award, 2012 Yahoo Labs FREP award, 2009 NSF CAREER award, the 2006 Microsoft Research New Faculty Fellowship and a number of Google Research awards.
Honors & Awards
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W.M. Keck Faculty Scholar, Stanford University (2012-2016)
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Best Paper (Runner-Up), IEEE Conference on Computer Vision and Pattern Recognition (CVPR) (2010)
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Kusaka Memorial Prize in Physics, Princeton University (1999)
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Martin Dale Fellowship, Princeton University (1999 - 2000)
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Fellowship for New Americans, Paul and Daisy Soros (1999 - 2003)
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Postgraduate Fellowship, National Science Foundation (1999 - 2003)
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Best Short Course Prize, IEEE ICCV (2005)
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New Faculty Fellowship, Microsoft Research (2006)
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Career Award, NSF (2009)
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Fellowship, Alfred P. Sloan (2011)
Professional Education
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B.A., Princeton University, Physics (1999)
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Master, California Institute of Technology, Electrical Engineering (2001)
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PhD, California Institute of Technology, Electrical Engineering (2005)
Current Research and Scholarly Interests
Human vision, high-level visual recognition, computational neuroscience
2014-15 Courses
- Computer Vision: Foundations and Applications
CS 131 (Aut) - Convolutional Neural Networks for Visual Recognition
CS 231N (Win) - The Cutting Edge of Computer Vision
CS 231B (Spr) -
Independent Studies (19)
- Advanced Reading and Research
CS 499 (Aut, Win, Spr, Sum) - Advanced Reading and Research
CS 499P (Aut, Win, Spr, Sum) - Computer Laboratory
CS 393 (Spr, Sum) - Curricular Practical Training
CS 390A (Aut, Win, Spr, Sum) - Curricular Practical Training
CS 390B (Aut, Win, Spr, Sum) - Curricular Practical Training
CS 390C (Aut, Win, Spr, Sum) - Directed Reading in Neurosciences
NEPR 299 (Aut, Win, Spr, Sum) - Graduate Research
NEPR 399 (Aut, Win, Spr, Sum) - Independent Database Project
CS 395 (Spr, Sum) - Independent Project
CS 399 (Aut, Win, Spr, Sum) - Independent Project
CS 399P (Aut, Win, Spr, Sum) - Independent Work
CS 199 (Aut, Win, Spr, Sum) - Independent Work
CS 199P (Spr, Sum) - Part-Time Curricular Practical Training
CS 390Q (Spr) - Part-Time Curricular Practical Training
CS 390R (Sum) - Part-time Curricular Practical Training
CS 390P (Win, Spr) - Programming Service Project
CS 192 (Spr, Sum) - Senior Project
CS 191 (Aut, Win, Spr, Sum) - Writing Intensive Senior Project (WIM)
CS 191W (Aut, Win, Spr)
- Advanced Reading and Research
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Prior Year Courses
2013-14 Courses
- Advanced Reading in Computer Vision
CS 331A (Win) - Computer Vision: Foundations and Applications
CS 131 (Aut) - High-Level Vision: Object Representation
CS 431, PSYCH 250 (Spr)
2012-13 Courses
- Advanced Reading in Computer Vision
CS 331 (Aut) - Introduction to Computer Vision
CS 231A (Aut) - The Cutting Edge of Computer Vision
CS 231B (Spr)
2011-12 Courses
- Introduction to Computer Vision
CS 231A (Aut) - Introduction to Computer Vision Laboratory
CS 231AL (Aut)
- Advanced Reading in Computer Vision
Journal Articles
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Comprehensive next-generation sequence analyses of the entire mitochondrial genome reveal new insights into the molecular diagnosis of mitochondrial DNA disorders
GENETICS IN MEDICINE
2013; 15 (5): 388-394
Abstract
Purpose:The application of massively parallel sequencing technology to the analysis of the mitochondrial genome has demonstrated great improvement in the molecular diagnosis of mitochondrial DNA-related disorders. The objective of this study was to investigate the performance characteristics and to gain new insights into the analysis of the mitochondrial genome.Methods:The entire mitochondrial genome was analyzed as a single amplicon using a long-range PCR-based enrichment approach coupled with massively parallel sequencing. The interference of the nuclear mitochondrial DNA homologs was distinguished from the actual mitochondrial DNA sequences by comparison with the results obtained from conventional PCR-based Sanger sequencing using multiple pairs of primers.Results:Our results demonstrated the uniform coverage of the entire mitochondrial genome. Massively parallel sequencing of the single amplicon revealed the presence of single-nucleotide polymorphisms and nuclear homologs of mtDNA sequences that cause the erroneous and inaccurate variant calls when PCR/Sanger sequencing approach was used. This single amplicon massively parallel sequencing strategy provides an accurate quantification of mutation heteroplasmy as well as the detection and mapping of mitochondrial DNA deletions.Conclusion:The ability to quantitatively and qualitatively evaluate every single base of the entire mitochondrial genome is indispensible to the accurate molecular diagnosis and genetic counseling of mitochondrial DNA-related disorders. This new approach may be considered as first-line testing for comprehensive analysis of the mitochondrial genome.Genet Med 2013:15(5):388-394.
View details for DOI 10.1038/gim.2012.144
View details for Web of Science ID 000318888600011
View details for PubMedID 23288206
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Biodistribution, pharmacokinetics and toxicology of Ag2S near-infrared quantum dots in mice
BIOMATERIALS
2013; 34 (14): 3639-3646
Abstract
Ag2S quantum dots (QDs) have been demonstrated as a promising near-infrared II (NIR-II, 1.0-1.4 ?m) emitting nanoprobe for in vivo imaging and detection. In this work, we carefully study the long-term in vivo biodistribution of Ag2S QDs functionalized with polyethylene glycol (PEG) and systematically examine the potential toxicity of Ag2S QDs over time. Our results show that PEGylated-Ag2S QDs are mainly accumulated in the reticuloendothelial system (RES) including liver and spleen after intravenous administration and can be gradually cleared, mostly by fecal excretion. PEGylated-Ag2S QDs do not cause appreciable toxicity at our tested doses (15 and 30 mg/kg) to the treated mice over a period of 2 months as evidenced by blood biochemistry, hematological analysis and histological examinations. Our work lays a solid foundation for further biomedical applications of Ag2S QDs as an important in vivo imaging agent in the NIR-II region.
View details for DOI 10.1016/j.biomaterials.2013.01.089
View details for Web of Science ID 000317534200010
View details for PubMedID 23415643
- Differential Connectivity Within the Parahippocampal Place Area NeuroImage 2013
- Good Exemplars of Natural Scene Categories Elicit Clearer Patterns than Bad Exemplars but not Greater BOLD Activity PLoS ONE. 2013
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Impact of restricted marital practices on genetic variation in an endogamous Gujarati group
AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY
2012; 149 (1): 92-103
Abstract
Recent studies have examined the influence on patterns of human genetic variation of a variety of cultural practices. In India, centuries-old marriage customs have introduced extensive social structuring into the contemporary population, potentially with significant consequences for genetic variation. Social stratification in India is evident as social classes that are defined by endogamous groups known as castes. Within a caste, there exist endogamous groups known as gols (marriage circles), each of which comprises a small number of exogamous gotra (lineages). Thus, while consanguinity is strictly avoided and some randomness in mate selection occurs within the gol, gene flow is limited with groups outside the gol. Gujarati Patels practice this form of "exogamic endogamy." We have analyzed genetic variation in one such group of Gujarati Patels, the Chha Gaam Patels (CGP), who comprise individuals from six villages. Population structure analysis of 1,200 autosomal loci offers support for the existence of distinctive multilocus genotypes in the CGP with respect to both non-Gujaratis and other Gujaratis, and indicates that CGP individuals are genetically very similar. Analysis of Y-chromosomal and mitochondrial haplotypes provides support for both patrilocal and patrilineal practices within the gol, and a low-level of female gene flow into the gol. Our study illustrates how the practice of gol endogamy has introduced fine-scale genetic structure into the population of India, and contributes more generally to an understanding of the way in which marriage practices affect patterns of genetic variation.
View details for DOI 10.1002/ajpa.22101
View details for Web of Science ID 000307729300009
View details for PubMedID 22729696
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Ag2S Quantum Dot: A Bright and Biocompatible Fluorescent Nanoprobe in the Second Near-Infrared Window
ACS NANO
2012; 6 (5): 3695-3702
Abstract
Ag(2)S quantum dots (QDs) emitting in the second near-infrared region (NIR-II, 1.0-1.4 ?m) are demonstrated as a promising fluorescent probe with both bright photoluminescence and high biocompatibility for the first time. Highly selective in vitro targeting and imaging of different cell lines are achieved using biocompatible NIR-II Ag(2)S QDs with different targeting ligands. The cytotoxicity study illustrates the Ag(2)S QDs with negligible effects in altering cell proliferation, triggering apoptosis and necrosis, generating reactive oxygen species, and causing DNA damage. Our results have opened up the possibilities of using these biocompatible Ag(2)S QDs for in vivo anatomical imaging and early stage tumor diagnosis with deep tissue penetration, high sensitivity, and elevated spatial and temporal resolution owing to their high emission efficiency in the unique NIR-II imaging window.
View details for DOI 10.1021/nn301218z
View details for Web of Science ID 000304231700007
View details for PubMedID 22515909
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Guidelines for the use and interpretation of assays for monitoring autophagy
AUTOPHAGY
2012; 8 (4): 445-544
Abstract
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
View details for DOI 10.4161/auto.19496
View details for Web of Science ID 000305403400002
View details for PubMedID 22966490
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The Integrative Effects of Cognitive Reappraisal on Negative Affect: Associated Changes in Secretory Immunoglobulin A, Unpleasantness and ERP Activity
PLOS ONE
2012; 7 (2)
Abstract
Although the regulatory role of cognitive reappraisal in negative emotional responses is widely recognized, this reappraisal's effect on acute saliva secretory immunoglobulin A (SIgA), as well as the relationships among affective, immunological, and event-related potential (ERP) changes, remains unclear. In this study, we selected only people with low positive coping scores (PCSs) as measured by the Trait Coping Style Questionnaire to avoid confounding by intrinsic coping styles. First, we found that the acute stress of viewing unpleasant pictures consistently decreased SIgA concentration and secretion rate, increased perceptions of unpleasantness and amplitude of late positive potentials (LPPs) between 200-300 ms and 400-1000 ms. After participants used cognitive reappraisal, their SIgA concentration and secretion rate significantly increased and their unpleasantness and LPP amplitudes significantly decreased compared with a control condition. Second, we found a significantly positive correlation between the increases in SIgA and the decreases in unpleasantness and a significantly negative correlation between the increases in SIgA and the increases in LPP across the two groups. This study is the first to demonstrate that cognitive reappraisal reverses the decrease of SIgA. In addition, it revealed strong correlations among affective, SIgA and electrophysiological changes with convergent multilevel evidence.
View details for DOI 10.1371/journal.pone.0030761
View details for Web of Science ID 000301979000013
View details for PubMedID 22319586
- Voxel-Level Functional Connectivity using Spatial Regularization NeuroImage 2012
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Learning Latent Temporal Structure for Complex Event Detection
2012 IEEE CONFERENCE ON COMPUTER VISION AND PATTERN RECOGNITION (CVPR)
2012: 1250-1257
View details for Web of Science ID 000309166201051
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Hedging Your Bets: Optimizing Accuracy-Specificity Trade-offs in Large Scale Visual Recognition
2012 IEEE CONFERENCE ON COMPUTER VISION AND PATTERN RECOGNITION (CVPR)
2012: 3450-3457
View details for Web of Science ID 000309166203078
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A Codebook-Free and Annotation-Free Approach for Fine-Grained Image Categorization
2012 IEEE CONFERENCE ON COMPUTER VISION AND PATTERN RECOGNITION (CVPR)
2012: 3466-3473
View details for Web of Science ID 000309166203080
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Extended Graphical Model for Analysis of Dynamic Contrast-Enhanced MRI
MAGNETIC RESONANCE IN MEDICINE
2011; 66 (3): 868-878
Abstract
Kinetic analysis with mathematical models has become increasingly important to quantify physiological parameters in computed tomography (CT), positron emission tomography (PET), and dynamic contrast-enhanced MRI (DCE-MRI). The modified Kety/Tofts model and the graphical (Patlak) model have been widely applied to DCE-MRI results in disease processes such as cancer, inflammation, and ischemia. In this article, an intermediate model between the modified Kety/Tofts and Patlak models is derived from a mathematical expansion of the modified Kety/Tofts model. Simulations and an in vivo experiment involving DCE-MRI of carotid atherosclerosis were used to compare the new extended graphical model with the modified Kety/Tofts model and the Patlak model. In our simulated circumstances and the carotid artery application, we found that the extended graphical model exhibited lower noise sensitivity and provided more accurate estimates of the volume transfer constant (K(trans)) and fractional plasma volume (v(p)) than the modified Kety/Tofts model for DCE-MRI acquisitions of total duration less than 100-300 s, depending on kinetic parameters. In comparison with the Patlak model, we found that the extended graphical model exhibited 74.4-99.8% less bias in estimates of K(trans). Thus, the extended graphical model may allow kinetic modeling of DCE-MRI results with shortened data acquisition periods, without sacrificing accuracy in estimates of K(trans) and v(p).
View details for DOI 10.1002/mrm.22819
View details for Web of Science ID 000293988000028
View details for PubMedID 21394770
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Human Action Recognition by Learning Bases of Action Attributes and Parts
2011 IEEE INTERNATIONAL CONFERENCE ON COMPUTER VISION (ICCV)
2011: 1331-1338
View details for Web of Science ID 000300061900169
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Combining Randomization and Discrimination for Fine-Grained Image Categorization
2011 IEEE CONFERENCE ON COMPUTER VISION AND PATTERN RECOGNITION (CVPR)
2011: 1577-1584
View details for Web of Science ID 000295615801084
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Bayesian Variable Selection in Structured High-Dimensional Covariate Spaces With Applications in Genomics
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
2010; 105 (491): 1202-1214
View details for DOI 10.1198/jasa.2010.tm08177
View details for Web of Science ID 000283695300034
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A PKC-beta inhibitor treatment reverses cardiac microvascular barrier dysfunction in diabetic rats
MICROVASCULAR RESEARCH
2010; 80 (1): 158-165
Abstract
The PKC-beta inhibitor ruboxistaurin (RBX or LY333531) prevents diabetic renal and retinal microvascular complications. However, the effect of RBX on diabetic cardiac microvascular dysfunction is still unclear. In this study, we aimed to investigate the effects and mechanisms of RBX treatment upon cardiac endothelial barrier dysfunction in high glucose states. We demonstrated RBX treatment suppressed high glucose induced PKC-betaII activation and phosphorylation of beta-catenin in vivo and in vitro experiments. Meanwhile, RBX treatment protected cardiac microvascular barrier function in diabetic animals and monolayer barrier function of cultured cardiac microvascular endothelial cells (CMECs), reproducing the same effect as PKC-betaII siRNA. These results provide new insight into protective properties of PKC-beta inhibitor against cardiac endothelial barrier dysfunction. PKC-beta inhibitor RBX prevented chronic cardiac microvascular barrier dysfunction and improved endothelial cell-cell junctional function in high glucose states.
View details for DOI 10.1016/j.mvr.2010.01.003
View details for Web of Science ID 000278950700022
View details for PubMedID 20079359
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Modeling Temporal Structure of Decomposable Motion Segments for Activity Classification
COMPUTER VISION-ECCV 2010, PT II
2010; 6312: 392-405
View details for Web of Science ID 000286164000029
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Grouplet: A Structured Image Representation for Recognizing Human and Object Interactions
2010 IEEE CONFERENCE ON COMPUTER VISION AND PATTERN RECOGNITION (CVPR)
2010: 9-16
View details for Web of Science ID 000287417500002
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Modeling Mutual Context of Object and Human Pose in Human-Object Interaction Activities
2010 IEEE CONFERENCE ON COMPUTER VISION AND PATTERN RECOGNITION (CVPR)
2010: 17-24
View details for Web of Science ID 000287417500003
- Neural mechanisms of rapid natural scene categorization in human visual cortex Nature 2009
- Natural scene categories revealed in distributed patterns of activity in the human brain Journal of Neuroscience 2009
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Therapeutic strategies for Parkinson's disease: The ancient meets the future - Traditional Chinese herbal medicine, electroacupuncture, gene therapy and stem cells
NEUROCHEMICAL RESEARCH
2008; 33 (10): 1956-1963
Abstract
In China, it has been estimated that there are more than 2.0 million people suffering from Parkinson's disease, which is currently becoming one of the most common chronic neurodegenerative disorders during recent years. For many years, scientists have struggled to find new therapeutic approaches for this disease. Since 1994, our research group led by Drs. Ji-Sheng Han and Xiao-Min Wang of Neuroscience Research Institute, Peking University has developed several prospective treatment strategies for the disease. These studies cover the traditional Chinese medicine-herbal formula or acupuncture, and modern technologies such as gene therapy or stem cell replacement therapy, and have achieved some original results. It hopes that these data may be beneficial for the research development and for the future clinical utility for treatment of Parkinson's disease.
View details for DOI 10.1007/s11064-008-9691-z
View details for Web of Science ID 000259190900008
View details for PubMedID 18404373
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Prevalence of pathogenic BRCA1 mutation carriers in 5 US racial/ethnic groups
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
2007; 298 (24): 2869-2876
Abstract
Information on the prevalence of pathogenic BRCA1 mutation carriers in racial/ethnic minority populations is limited.To estimate BRCA1 carrier prevalence in Hispanic, African American, and Asian American female breast cancer patients compared with non-Hispanic white patients with and without Ashkenazi Jewish ancestry.We estimated race/ethnicity-specific prevalence of BRCA1 in a population-based, multiethnic series of female breast cancer patients younger than 65 years at diagnosis who were enrolled at the Northern California site of the Breast Cancer Family Registry during the period 1996-2005. Race/ethnicity and religious ancestry were based on self-report. Weighted estimates of prevalence and 95% confidence intervals (CIs) were based on Horvitz-Thompson estimating equations.Estimates of BRCA1 prevalence.Estimates of BRCA1 prevalence were 3.5% (95% CI, 2.1%-5.8%) in Hispanic patients (n = 393), 1.3% (95% CI, 0.6%-2.6%) in African American patients (n = 341), and 0.5% (95% CI, 0.1%-2.0%) in Asian American patients (n = 444), compared with 8.3% (95% CI, 3.1%-20.1%) in Ashkenazi Jewish patients (n = 41) and 2.2% (95% CI, 0.7%-6.9%) in other non-Hispanic white patients (n = 508). Prevalence was particularly high in young (<35 years) African American patients (5/30 patients [16.7%]; 95% CI, 7.1%-34.3%). 185delAG was the most common mutation in Hispanics, found in 5 of 21 carriers (24%).Among African American, Asian American, and Hispanic patients in the Northern California Breast Cancer Family Registry, the prevalence of BRCA1 mutation carriers was highest in Hispanics and lowest in Asian Americans. The higher carrier prevalence in Hispanics may reflect the presence of unrecognized Jewish ancestry in this population.
View details for Web of Science ID 000251816000019
View details for PubMedID 18159056
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F-18-labeled mini-PEG spacered RGD dimer (F-18-FPRGD2): synthesis and microPET imaging of alpha(v)beta(3) integrin expression
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
2007; 34 (11): 1823-1831
Abstract
We have previously reported that (18)F-FB-E[c(RGDyK)](2) ((18)F-FRGD2) allows quantitative PET imaging of integrin alpha(v)beta(3) expression. However, the potential clinical translation was hampered by the relatively low radiochemical yield. The goal of this study was to improve the radiolabeling yield, without compromising the tumor targeting efficiency and in vivo kinetics, by incorporating a hydrophilic bifunctional mini-PEG spacer.(18)F-FB-mini-PEG-E[c(RGDyK)](2) ((18)F-FPRGD2) was synthesized by coupling N-succinimidyl-4-(18)F-fluorobenzoate ((18)F-SFB) with NH(2)-mini-PEG-E[c(RGDyK)](2) (denoted as PRGD2). In vitro receptor binding affinity, metabolic stability, and integrin alpha(v)beta(3) specificity of the new tracer (18)F-FPRGD2 were assessed. The diagnostic value of (18)F-FPRGD2 was evaluated in subcutaneous U87MG glioblastoma xenografted mice and in c-neu transgenic mice by quantitative microPET imaging studies.The decay-corrected radiochemical yield based on (18)F-SFB was more than 60% with radiochemical purity of >99%. (18)F-FPRGD2 had high receptor binding affinity, metabolic stability, and integrin alpha(v)beta(3)-specific tumor uptake in the U87MG glioma xenograft model comparable to those of (18)F-FRGD2. The kidney uptake was appreciably lower for (18)F-FPRGD2 compared with (18)F-FRGD2 [2.0 +/- 0.2%ID/g for (18)F-FPRGD2 vs 3.0 +/- 0.2%ID/g for (18)F-FRGD2 at 1 h post injection (p.i.)]. The uptake in all the other organs except the urinary bladder was at background level. (18)F-FPRGD2 also exhibited excellent tumor uptake in c-neu oncomice (3.6 +/- 0.1%ID/g at 30 min p.i.).Incorporation of a mini-PEG spacer significantly improved the overall radiolabeling yield of (18)F-FPRGD2. (18)F-FPRGD2 also had reduced renal uptake and similar tumor targeting efficacy as compared with (18)F-FRGD2. Further testing and clinical translation of (18)F-FPRGD2 are warranted.
View details for DOI 10.1007/s00259-007-0427-0
View details for Web of Science ID 000250205400015
View details for PubMedID 17492285
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MicroPET of tumor integrin alpha(v)beta(3) expression using F-18-Labeled PEGylated tetrameric RGD peptide (F-18-FPRGD4)
JOURNAL OF NUCLEAR MEDICINE
2007; 48 (9): 1536-1544
Abstract
In vivo imaging of alpha(v)beta(3) expression has important diagnostic and therapeutic applications. Multimeric cyclic RGD peptides are capable of improving the integrin alpha(v)beta(3)-binding affinity due to the polyvalency effect. Here we report an example of (18)F-labeled tetrameric RGD peptide for PET of alpha(v)beta(3) expression in both xenograft and spontaneous tumor models.The tetrameric RGD peptide E{E[c(RGDyK)](2)}(2) was derived with amino-3,6,9-trioxaundecanoic acid (mini-PEG; PEG is poly(ethylene glycol)) linker through the glutamate alpha-amino group. NH(2)-mini-PEG-E{E[c(RGDyK)](2)}(2) (PRGD4) was labeled with (18)F via the N-succinimidyl-4-(18)F-fluorobenzoate ((18)F-SFB) prosthetic group. The receptor-binding characteristics of the tetrameric RGD peptide tracer (18)F-FPRGD4 were evaluated in vitro by a cell-binding assay and in vivo by quantitative microPET imaging studies.The decay-corrected radiochemical yield for (18)F-FPRGD4 was about 15%, with a total reaction time of 180 min starting from (18)F-F(-). The PEGylation had minimal effect on integrin-binding affinity of the RGD peptide. (18)F-FPRGD4 has significantly higher tumor uptake compared with monomeric and dimeric RGD peptide tracer analogs. The receptor specificity of (18)F-FPRGD4 in vivo was confirmed by effective blocking of the uptake in both tumors and normal organs or tissues with excess c(RGDyK).The tetrameric RGD peptide tracer (18)F-FPRGD4 possessing high integrin-binding affinity and favorable biokinetics is a promising tracer for PET of integrin alpha(v)beta(3) expression in cancer and other angiogenesis related diseases.
View details for DOI 10.2967/jnumed.107.040816
View details for Web of Science ID 000252894700042
View details for PubMedID 17704249
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HIF-dependent antitumorigenic effect of antioxidants in vivo
CANCER CELL
2007; 12 (3): 230-238
Abstract
The antitumorigenic activity of antioxidants has been presumed to arise from their ability to squelch DNA damage and genomic instability mediated by reactive oxygen species (ROS). Here, we report that antioxidants inhibited three tumorigenic models in vivo. Inhibition of a MYC-dependent human B lymphoma model was unassociated with genomic instability but was linked to diminished hypoxia-inducible factor (HIF)-1 levels in a prolyl hydroxylase 2 and von Hippel-Lindau protein-dependent manner. Ectopic expression of an oxygen-independent, stabilized HIF-1 mutant rescued lymphoma xenografts from inhibition by two antioxidants: N-acetylcysteine and vitamin C. These findings challenge the paradigm that antioxidants diminish tumorigenesis primarily through decreasing DNA damage and mutations and provide significant support for a key antitumorigenic effect of diminishing HIF levels.
View details for DOI 10.1016/j.ccr.2007.08.004
View details for Web of Science ID 000249514500006
View details for PubMedID 17785204
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Detection of separated analytes in subnanoliter volumes using coaxial thermal lensing
ANALYTICAL CHEMISTRY
2007; 79 (14): 5264-5271
Abstract
A collinear-beam thermal lens detector has been constructed and its properties were characterized. Its application to the high-performance liquid chromatography (HPLC) separation of a mixture of five anthraquinone dyes dissolved in water shows a linear response over 3.5 orders of magnitude and a detection limit that is subnanomolar in the dye concentrations. These results are compared with those obtained previously using cavity ring-down spectroscopy (CRDS) in a Brewster's angle flow cell (Bechtel, K. L.; Zare, R. N.; Kachanov, A. A.; Sanders, S. S.; Paldus, B. A. Anal. Chem. 2005, 77, 1177-1182). The peak-to-peak baseline noise of the thermal lensing detection is 3.5 x 10(-8) absorbance units (AU) with a path length of 200 microm, whereas the peak-to-peak baseline noise of CRDS detection is approximately 2 x 10(-7) AU with a path length of 300 microm. Both of these figures of merit should be compared to the peak-to-peak baseline noise of one of the best commercial UV-vis HPLC detection systems, which is approximately 5 x 10(-6) AU with a path length of 10 mm (1-s integration time). Therefore, the thermal lensing technique has a demonstrated sensitivity of subnanomolar detection that is approximately 140 times better than that of the best commercial UV-vis detector and approximately 5 times better than that of CRDS.
View details for DOI 10.1021/ac0705925
View details for Web of Science ID 000247992600021
View details for PubMedID 17569503
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Characterization of two types of silanol groups on fused-silica surfaces using evanescent-wave cavity ring-down spectroscopy
ANALYTICAL CHEMISTRY
2007; 79 (10): 3654-3661
Abstract
Evanescent-wave cavity ring-down spectroscopy has been applied to a planar fused-silica surface covered with crystal violet (CV+) cations to characterize the silanol groups indirectly. A radiation-polarization dependence of the adsorption isotherm of CV+ at the CH3CN/silica interface is measured and fit to a two-site Langmuir equation to determine the relative populations of two different types of isolated silanol groups. CV+ binding at type I sites yields a free energy of adsorption of -29.9 +/- 0.2 kJ/mol and a saturation surface density of (7.4 +/- 0.5) x 10(12) cm(-2), whereas the values of -17.9 +/- 0.4 kJ/mol and (3.1 +/- 0.4) x 10(13) cm(-2) are obtained for the type II sites. The CV+ cations, each with a planar area of approximately 120 A2, seem to be aligned randomly while lying over the SiO- type I sites, thereby suggesting that this type of site may be surrounded by a large empty surface area (>480 A2). In contrast, the CV+ cations on a type II sites are restricted with an average angle of approximately 40 degrees tilted off the surface normal, suggesting that the CV+ cations on these sites are grouped closely together. The average tilt angle increases with increasing concentration of crystal violet so that CV+ cations may be separated from each other to minimize the repulsion of nearby CV+ and SiOH sites.
View details for DOI 10.1021/ac062386n
View details for Web of Science ID 000246414400017
View details for PubMedID 17429945
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Breast and ovarian cancer in relatives of cancer patients, with and without BRCA mutations
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
2006; 15 (2): 359-363
Abstract
First-degree relatives of patients with breast or ovarian cancer have increased risks for these cancers. Little is known about how their risks vary with the patient's cancer site, carrier status for predisposing genetic mutations, or age at cancer diagnosis.We evaluated breast and ovarian cancer incidence in 2,935 female first-degree relatives of non-Hispanic White female patients with incident invasive cancers of the breast (n = 669) or ovary (n = 339) who were recruited from a population-based cancer registry in northern California. Breast cancer patients were tested for BRCA1 and BRCA2 mutations. Ovarian cancer patients were tested for BRCA1 mutations. We estimated standardized incidence ratios (SIR) and 95% confidence intervals (95% CI) for breast and ovarian cancer among the relatives according to the patient's mutation status, cancer site, and age at cancer diagnosis.In families of patients who were negative or untested for BRCA1 or BRCA2 mutations, risks were elevated only for the patient's cancer site. The breast cancer SIR was 1.5 (95% CI, 1.2-1.8) for relatives of breast cancer patients, compared with 1.1 (95% CI, 0.8-1.6) for relatives of ovarian cancer patients (P = 0.12 for difference by patient's cancer site). The ovarian cancer SIR was 0.9 (95% CI, 0.5-1.4) for relatives of breast cancer patients, compared with 1.9 (95% CI, 1.0-4.0) for relatives of ovarian cancer patients (P = 0.04 for difference by site). In families of BRCA1-positive patients, relatives' risks also correlated with the patient's cancer site. The breast cancer SIR was 10.6 (95% CI, 5.2-21.6) for relatives of breast cancer patients, compared with 3.3 (95% CI, 1.4-7.3) for relatives of ovarian cancer patients (two-sided P = 0.02 for difference by site). The ovarian cancer SIR was 7.9 (95% CI, 1.2-53.0) for relatives of breast cancer patients, compared with 11.3 (3.6-35.9) for relatives of ovarian cancer patients (two-sided P = 0.37 for difference by site). Relatives' risks were independent of patients' ages at diagnosis, with one exception: In families ascertained through a breast cancer patient without BRCA mutations, breast cancer risks were higher if the patient had been diagnosed before age 40 years.In families of patients with and without BRCA1 mutations, breast and ovarian cancer risks correlate with the patient's cancer site. Moreover, in families of breast cancer patients without BRCA mutations, breast cancer risk depends on the patient's age at diagnosis. These patterns support the presence of genes that modify risk specific to cancer site, in both carriers and noncarriers of BRCA1 and BRCA2 mutations.
View details for DOI 10.1158/1055-9965.EPI-05-0687
View details for Web of Science ID 000235587200026
View details for PubMedID 16492929
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The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers
BRAIN RESEARCH
2005; 1048 (1-2): 59-68
Abstract
The endoplasmic reticulum (ER) plays an important role in ischemic neuronal cell death. In order to determine the effect of dantrolene, a ryanodine receptor antagonist, on ER stress response and ischemic brain injury, we investigated changes in ER stress-related molecules, that is phosphorylated form of double-stranded RNA-activated protein kinase (PKR)-like ER kinase (p-PERK), phosphorylated form of eukaryotic initiation factor 2alpha (p-eIF2alpha), activating transcription factor-4 (ATF-4), and C/EBP-homologous protein (CHOP), as well as terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) in the peri-ischemic area and ischemic core region of rat brain after transient middle cerebral artery occlusion (MCAO). In contrast to the cases treated with vehicle, the infarct volume and TUNEL-positive cells were significantly reduced at 24 h of reperfusion by treatment with dantrolene. The immunoreactivities for p-PERK, p-eIF2alpha, ATF-4, and CHOP were increased at the ischemic peripheral region after MCAO, which were partially inhibited by dantrolene treatment. The present results suggest that dantrolene significantly decreased infarct volume and provided neuroprotective effect on rats after transient MCAO by reducing ER stress-mediated apoptotic signal pathway activation in the ischemic area.
View details for DOI 10.1016/j.brainres.2005.04.058
View details for Web of Science ID 000230259600007
View details for PubMedID 15921666
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Familial gastrointestinal stromal tumor syndrome: Phenotypic and molecular features in a kindred
JOURNAL OF CLINICAL ONCOLOGY
2005; 23 (12): 2735-2743
Abstract
Members of a family with hereditary gastrointestinal stromal tumors (GISTs) and a germline KIT oncogene mutation were evaluated for other potential syndrome manifestations. A tumor from the proband was analyzed to compare features with sporadic GISTs.Members of a kindred in which six relatives in four consecutive generations comprised an autosomal dominant pattern of documented GISTs and cutaneous lesions underwent physical examination, imaging studies, and germline KIT analysis. A recurrent GIST from the proband was studied using microarray, karyotypic, immunohistochemical, and immunoblotting techniques.In addition to evidence of multiple GISTs, lentigines, malignant melanoma, and an angioleiomyoma were identified in relatives. A previously reported gain-of-function missense mutation in KIT exon 11 (T --> C) that results in a V559A substitution within the juxtamembrane domain was identified in three family members. The proband's recurrent gastric GIST had a 44,XY-14,-22 karyotype and immunohistochemical evidence of strong diffuse cytoplasmic KIT expression without expression of actin, desmin, or S-100. Immunoblotting showed strong expression of phosphorylated KIT and downstream signaling intermediates (AKT and MAPK) at levels comparable with those reported in sporadic GISTs. cDNA array profiling demonstrated clustering with sporadic GISTs, and expression of GIST markers comparable to sporadic GISTs.These studies provide the first evidence that gene expression and mechanisms of cytogenetic progression and cell signaling are indistinguishable in familial and sporadic GISTs. Current investigations of molecularly targeted therapies in GIST patients provide opportunities to increase the understanding of features of the hereditary syndrome, and risk factors and molecular pathways of the neoplastic phenotypes.
View details for DOI 10.1200/JCO.2005.06.009
View details for Web of Science ID 000228563600021
View details for PubMedID 15837988
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Molecular orientation study of methylene blue at an air/fused-silica interface using evanescent-wave cavity ring-down spectroscopy
JOURNAL OF PHYSICAL CHEMISTRY B
2005; 109 (8): 3330-3333
Abstract
Using evanescent-wave cavity ring-down spectroscopy (EW-CRDS), we monitored the change in the absorbance of a thin film of methylene blue (MB) at an air/fused-silica interface while varying the polarization of the incident light (600 nm). We derived the average orientation angle of the planar MB molecules with respect to the surface normal and observed that the average orientation angle decreases as the surface concentration increases. At low surface concentrations, the MB molecules lie almost flat on the surface, whereas at higher surface concentrations the molecules become vertically oriented.
View details for DOI 10.1021/jp045290a
View details for Web of Science ID 000227247100037
View details for PubMedID 16851361
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Oral contraceptive use and risk of early-onset breast cancer in carriers and noncarriers of BRCA1 and BRCA2 mutations
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
2005; 14 (2): 350-356
Abstract
Recent oral contraceptive use has been associated with a small increase in breast cancer risk and a substantial decrease in ovarian cancer risk. The effects on risks for women with germ line mutations in BRCA1 or BRCA2 are unclear.Subjects were population-based samples of Caucasian women that comprised 1,156 incident cases of invasive breast cancer diagnosed before age 40 (including 47 BRCA1 and 36 BRCA2 mutation carriers) and 815 controls from the San Francisco Bay area, California, Ontario, Canada, and Melbourne and Sydney, Australia. Relative risks by carrier status were estimated using unconditional logistic regression, comparing oral contraceptive use in case groups defined by mutation status with that in controls.After adjustment for potential confounders, oral contraceptive use for at least 12 months was associated with decreased breast cancer risk for BRCA1 mutation carriers [odds ratio (OR), 0.22; 95% confidence interval (CI), 0.10-0.49; P < 0.001], but not for BRCA2 mutation carriers (OR, 1.02; 95% CI, 0.34-3.09) or noncarriers (OR, 0.93; 95% CI, 0.69-1.24). First use during or before 1975 was associated with increased risk for noncarriers (OR, 1.52 per year of use before 1976; 95% CI, 1.22-1.91; P < 0.001).There was no evidence that use of current low-dose oral contraceptive formulations increases risk of early-onset breast cancer for mutation carriers, and there may be a reduced risk for BRCA1 mutation carriers. Because current formulations of oral contraceptives may reduce, or at least not exacerbate, ovarian cancer risk for mutation carriers, they should not be contraindicated for a woman with a germ line mutation in BRCA1 or BRCA2.
View details for Web of Science ID 000227113800010
View details for PubMedID 15734957
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Prevalence of BRCA1 mutation carriers among US non-Hispanic Whites
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
2004; 13 (12): 2078-2083
Abstract
Data from several countries indicate that 1% to 2% of Ashkenazi Jews carry a pathogenic ancestral mutation of the tumor suppressor gene BRCA1. However, the prevalence of BRCA1 mutations among non-Ashkenazi Whites is uncertain. We estimated mutation carrier prevalence in U.S. non-Hispanic Whites, specific for Ashkenazi status, using data from two population-based series of San Francisco Bay Area patients with invasive cancers of the breast or ovary, and data on breast and ovarian cancer risks in Ashkenazi and non-Ashkenazi carriers. Assuming that 90% of the BRCA1 mutations were detected, we estimate a carrier prevalence of 0.24% (95% confidence interval, 0.15-0.39%) in non-Ashkenazi Whites, and 1.2% (95% confidence interval, 0.5-2.6%) in Ashkenazim. When combined with U.S. White census counts, these prevalence estimates suggest that approximately 550,513 U.S. Whites (506,206 non-Ashkenazim and 44,307 Ashkenazim) carry germ line BRCA1 mutations. These estimates may be useful in guiding resource allocation for genetic testing and genetic counseling and in planning preventive interventions.
View details for Web of Science ID 000226077100015
View details for PubMedID 15598764
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Design of polarization beam splitter in two-dimensional triangular photonic crystals
CHINESE PHYSICS LETTERS
2004; 21 (7): 1285-1288
View details for Web of Science ID 000222542100028
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Measurement of inclusive momentum spectra and multiplicity distributions of charged particles at root s similar to 2-5 GeV
PHYSICAL REVIEW D
2004; 69 (7)
View details for DOI 10.1103/PhysRevD.69.072002
View details for Web of Science ID 000221253900006
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Adsorption of crystal violet to the silica-water interface monitored by evanescent wave cavity ring-down spectroscopy
JOURNAL OF PHYSICAL CHEMISTRY B
2003; 107 (29): 7070-7075
View details for DOI 10.1021/jp027636s
View details for Web of Science ID 000184242600022
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Observation of a near-threshold enhancement in the p(p)over-bar mass spectrum from radiative J/psi ->gamma p(p)over-bar deecays
PHYSICAL REVIEW LETTERS
2003; 91 (2)
View details for DOI 10.1103/PhysRevLett.91.022001
View details for Web of Science ID 000184086000007
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Search for lepton flavor violation process J/psi -> e mu
PHYSICS LETTERS B
2003; 561 (1-2): 49-54
View details for DOI 10.1016/S0370-2693(03)00391-5
View details for Web of Science ID 000182760200006
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Measurements of the mass and full-width of the eta c meson
PHYSICS LETTERS B
2003; 555 (3-4): 174-180
View details for DOI 10.1016/S0370-2693(03)00074-1
View details for Web of Science ID 000181126100006
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Comparison of DNA- and RNA-based methods for detection of truncating BRCA1 mutations
HUMAN MUTATION
2002; 20 (1): 65-73
Abstract
A number of methods are used for mutational analysis of BRCA1, a large multi-exon gene. A comparison was made of five methods to detect mutations generating premature stop codons that are predicted to result in synthesis of a truncated protein in BRCA1. These included four DNA-based methods: two-dimensional gene scanning (TDGS), denaturing high performance liquid chromatography (DHPLC), enzymatic mutation detection (EMD), and single strand conformation polymorphism analysis (SSCP) and an RNA/DNA-based protein truncation test (PTT) with and without complementary 5' sequencing. DNA and RNA samples isolated from 21 coded lymphoblastoid cell line samples were tested. These specimens had previously been analyzed by direct automated DNA sequencing, considered to be the optimum method for mutation detection. The set of 21 cell lines included 14 samples with 13 unique frameshift or nonsense mutations, three samples with two unique splice site mutations, and four samples without deleterious mutations. The present study focused on the detection of protein-truncating mutations, those that have been reported most often to be disease-causing alterations that segregate with cancer in families. PTT with complementary 5' sequencing correctly identified all 15 deleterious mutations. Not surprisingly, the DNA-based techniques did not detect a deletion of exon 22. EMD and DHPLC identified all of the mutations with the exception of the exon 22 deletion. Two mutations were initially missed by TDGS, but could be detected after slight changes in the test design, and five truncating mutations were missed by SSCP. It will continue to be important to use complementary methods for mutational analysis.
View details for DOI 10.1002/humu.10097
View details for Web of Science ID 000176744500008
View details for PubMedID 12112659
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The BES upgrade
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
2001; 458 (3): 627-637
View details for Web of Science ID 000167040900003
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Participation in the cooperative family registry for breast cancer studies: Issues of informed consent
JOURNAL OF THE NATIONAL CANCER INSTITUTE
2000; 92 (6): 452-456
View details for Web of Science ID 000085794200009
View details for PubMedID 10716962
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Thickness measurement of submonolayer native oxide films on silicon wafers
SOLID STATE TECHNOLOGY
2000; 43 (2): 87-?
View details for Web of Science ID 000085305000015
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The Eighth AACR American Cancer Society Award Lecture on Cancer Epidemiology and Prevention - Introduction
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
1999; 8 (8): 649-649
View details for Web of Science ID 000083705300001
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Measurement of the branching ratios for the decays of Ds(+) to eta pi(+), eta 'pi(+), eta rho(+), and eta 'rho(+)
PHYSICAL REVIEW D
1998; 58 (5)
View details for Web of Science ID 000075748700006
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Evidence for the leptonic decay D ->mu nu(mu)
PHYSICS LETTERS B
1998; 429 (1-2): 188-194
View details for Web of Science ID 000074694400026
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Measurement of the branching fractions of Lambda(+)(c)-> p(K)over-bar-n(pi)
PHYSICAL REVIEW D
1998; 57 (7): 4467-4470
View details for Web of Science ID 000072880400076
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New measurement of B -> D*pi branching fractions
PHYSICAL REVIEW LETTERS
1998; 80 (13): 2762-2766
View details for Web of Science ID 000072757000004
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Measurement of the total cross section for e(+)e(-)-> hadrons at root s=10.52 GeV
PHYSICAL REVIEW D
1998; 57 (3): 1350-1358
View details for Web of Science ID 000071834800006
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Direct measurement of B(D-s(+)->phi X+)
PHYSICAL REVIEW D
1998; 57 (1): 28-32
View details for Web of Science ID 000071320700005
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Measurements of the meson-photon transition form factors of light pseudoscalar mesons at large momentum transfer
PHYSICAL REVIEW D
1998; 57 (1): 33-54
View details for Web of Science ID 000071320700006
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Measurement of the decay amplitudes and branching fractions of B->J/psi K-* and B->J/psi K decays
PHYSICAL REVIEW LETTERS
1997; 79 (23): 4533-4537
View details for Web of Science ID A1997YK36500005
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Limit on the two-photon production of the glueball candidate f(J)(2220) at the Cornell electron storage ring
PHYSICAL REVIEW LETTERS
1997; 79 (20): 3829-3833
View details for Web of Science ID A1997YF78600008
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Study of the decay tau(-)->2 pi(-)pi(+)3 pi(0)nu(tau)
PHYSICAL REVIEW LETTERS
1997; 79 (20): 3814-3818
View details for Web of Science ID A1997YF78600005
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First observation of inclusive B decays to the charmed strange baryons xi(0)(c) and xi(+)(c)
PHYSICAL REVIEW LETTERS
1997; 79 (19): 3599-3603
View details for Web of Science ID A1997YF18600014
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Search for the decay tau(-)->4 pi(-)3 pi(+)(pi(0))nu(tau)
PHYSICAL REVIEW D
1997; 56 (9): R5297-R5300
View details for Web of Science ID A1997YF04400001
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Determination of the Michel parameters and the tau neutrino helicity in tau decay
PHYSICAL REVIEW D
1997; 56 (9): 5320-5329
View details for Web of Science ID A1997YF04400005
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New upper limit on the decay eta->e(+)e(-)
PHYSICAL REVIEW D
1997; 56 (9): 5359-5365
View details for Web of Science ID A1997YF04400007
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Observation of exclusive B decays to final states containing a charmed baryon
PHYSICAL REVIEW LETTERS
1997; 79 (17): 3125-3129
View details for Web of Science ID A1997YC78200008
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Inclusive decays B->DX and B->D*X
PHYSICAL REVIEW D
1997; 56 (7): 3783-3802
View details for Web of Science ID A1997YA57300002
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First observation of tau->3 pi eta nu(tau) and tau->f(1)pi nu(tau) decays
PHYSICAL REVIEW LETTERS
1997; 79 (13): 2406-2410
View details for Web of Science ID A1997XZ11400005
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Measurement of the (B)over-bar->Dl(nu)over-bar partial width and form factor parameters
PHYSICAL REVIEW LETTERS
1997; 79 (12): 2208-2212
View details for Web of Science ID A1997XW93900012
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Lambda(Lambda)over-bar production in two-photon interactions
PHYSICAL REVIEW D
1997; 56 (5): R2485-R2489
View details for Web of Science ID A1997XV62500001
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Observation of the decay D-s(+)->omega pi(+)
PHYSICAL REVIEW LETTERS
1997; 79 (8): 1436-1440
View details for Web of Science ID A1997XT12400004
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Search for neutrinoless tau decays involving pi(0) or eta mesons
PHYSICAL REVIEW LETTERS
1997; 79 (7): 1221-1224
View details for Web of Science ID A1997XR28700012
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Search for the decays B-0->D(*)D+(*)(-)
PHYSICAL REVIEW LETTERS
1997; 79 (5): 799-803
View details for Web of Science ID A1997XN80900007
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Studies of the Cabibbo-suppressed decays D+->pi(0)l(+)nu and D+->eta e(+)nu(e)
PHYSICS LETTERS B
1997; 405 (3-4): 373-378
View details for Web of Science ID A1997XP69800026
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Study of gluon versus quark fragmentation in Y->gg gamma and e(+)e(-)->q(q)over-bar gamma events at root s=10 GeV
PHYSICAL REVIEW D
1997; 56 (1): 17-22
View details for Web of Science ID A1997XH85700004
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Search for B->mu(nu)over-bar(mu)gamma and B->e(nu)over-bar(e)gamma
PHYSICAL REVIEW D
1997; 56 (1): 11-16
View details for Web of Science ID A1997XH85700003
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A measurement of the Michel parameters in leptonic decays of the tau
PHYSICAL REVIEW LETTERS
1997; 78 (25): 4686-4690
View details for Web of Science ID A1997XJ26900005
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nu(tau) helicity from h(+/-) energy correlations
PHYSICAL REVIEW D
1997; 55 (11): 7291-7295
View details for Web of Science ID A1997XD01800057
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Study of the B-0 semileptonic decay spectrum at the Y(4S) resonance
PHYSICS LETTERS B
1997; 399 (3-4): 321-328
View details for Web of Science ID A1997WX03700021
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Measurement of the direct photon spectrum in Y(1S) decays
PHYSICAL REVIEW D
1997; 55 (9): 5273-5281
View details for Web of Science ID A1997WX51900003
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Analysis of D+->K-S((0))K+ and D+->K-S((0))pi(+)
PHYSICAL REVIEW LETTERS
1997; 78 (17): 3261-3265
View details for Web of Science ID A1997WW39900009
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Search for neutrinoless tau decays: tau->e gamma and tau->mu gamma
PHYSICAL REVIEW D
1997; 55 (7): R3919-R3923
View details for Web of Science ID A1997WY65400001
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Observation of two excited charmed baryons decaying into Lambda(+)(c)pi(+/-)
PHYSICAL REVIEW LETTERS
1997; 78 (12): 2304-2308
View details for Web of Science ID A1997WP51300008
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Experimental tests of lepton universality in tau decay
PHYSICAL REVIEW D
1997; 55 (5): 2559-2576
View details for Web of Science ID A1997WL50300007
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Search for phi mesons in tau lepton decay
PHYSICAL REVIEW D
1997; 55 (3): R1119-R1123
View details for Web of Science ID A1997WF29700001
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First measurement of the B->pi l nu and B->rho(omega)l nu branching fractions
PHYSICAL REVIEW LETTERS
1996; 77 (25): 5000-5004
View details for Web of Science ID A1996VY11100007
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A search for nonresonant B+->h(+)h(-)h(+) decays
PHYSICAL REVIEW LETTERS
1996; 77 (22): 4503-4507
View details for Web of Science ID A1996VU50200006
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Measurement of the tau lepton lifetime
PHYSICS LETTERS B
1996; 388 (2): 402-408
View details for Web of Science ID A1996VU29400028
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Analysis of D-0->K(K)over-bar-X decays
PHYSICAL REVIEW D
1996; 54 (7): 4211-4220
View details for Web of Science ID A1996VM97700004
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Observation of an excited charmed baryon decaying into Xi(c)(0)pi(+)
PHYSICAL REVIEW LETTERS
1996; 77 (5): 810-813
View details for Web of Science ID A1996UY95200005
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Search for a vector glueball by a scan of the J/psi resonance
PHYSICAL REVIEW D
1996; 54 (1): 1221-1224
View details for Web of Science ID A1996UV18700059
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Measurement of the branching fraction for D-s(-)->phi pi(-)
PHYSICS LETTERS B
1996; 378 (1-4): 364-372
View details for Web of Science ID A1996UV05800055
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Decays of tau leptons to final states containing K-S(0) mesons
PHYSICAL REVIEW D
1996; 53 (11): 6037-6053
View details for Web of Science ID A1996UN90500005
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First observation of the decay tau(-)->K-eta nu(tau)
PHYSICAL REVIEW LETTERS
1996; 76 (22): 4119-4123
View details for Web of Science ID A1996UM24500005
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Measurement of the form factors for (B)over-bar(0)->D*(+)l(-)(nu)over-bar
PHYSICAL REVIEW LETTERS
1996; 76 (21): 3898-3902
View details for Web of Science ID A1996UL24700005
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A measurement of B(D-0->K-pi(+)pi(0))/B(D-0->K-pi(+))
PHYSICS LETTERS B
1996; 373 (4): 334-338
View details for Web of Science ID A1996UJ91100012
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Limits on flavor changing neutral currents in D-0 meson Decays
PHYSICAL REVIEW LETTERS
1996; 76 (17): 3065-3069
View details for Web of Science ID A1996UF74400006
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Tau decays into three charged leptons and two neutrinos
PHYSICAL REVIEW LETTERS
1996; 76 (15): 2637-2641
View details for Web of Science ID A1996UE19000009
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Measurement of the mass of the tau lepton
PHYSICAL REVIEW D
1996; 53 (1): 20-34
View details for Web of Science ID A1996TP72000004
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Direct measurement of the D-3 branching fraction to phi pi
PHYSICAL REVIEW D
1995; 52 (7): 3781-3784
View details for Web of Science ID A1995TL18200005
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DIRECT MEASUREMENT OF THE PSEUDOSCALAR DECAY CONSTANT, F(D-S)
PHYSICAL REVIEW LETTERS
1995; 74 (23): 4599-4602
View details for Web of Science ID A1995RB20000010
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AN EVALUATION OF GENETIC-HETEROGENEITY IN 145 BREAST-CANCER OVARIAN-CANCER FAMILIES
AMERICAN JOURNAL OF HUMAN GENETICS
1995; 56 (1): 254-264
View details for Web of Science ID A1995QC10100033
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MEASUREMENT OF THE MASS OF THE TAU-LEPTON
PHYSICAL REVIEW LETTERS
1992; 69 (21): 3021-3024
View details for Web of Science ID A1992JY87900006
Books and Book Chapters
- To err is human: investigating neural function by correlating error patterns with human behavior MIT Press, Cambridge, Massachusetts.. 2010
- Multi-view Object Categorization and Pose Estimation Studies in Computational Intelligence- Computer Vision 2010: 1
- What, Where and Who? Telling the Story of an Image by Activity Classification, Scene Recognition and Object Categorization Studies in Computational Intelligence- Computer Vision 2010: 1
Conference Proceedings
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INTERNAL REPRESENTATIONS OF REAL-WORLD SCENE CATEGORIES
MIT PRESS. 2013: 205-205
View details for Web of Science ID 000317030501155
- Object Discovery in 3D Scenes via Shape Analysis 2013
- Combining the Right Features for Complex Event Recognition 2013
- Discriminative Segment Annotation in Weakly Labeled Video 2013
- Detecting avocados to zucchinis: what have we done, and where are we going? 2013
- Video Event Understanding using Natural Language Descriptions 2013
- Social Role Discovery in Human Events 2013
- Object Bank: An Object-Level Image Representation for High-Level Visual Recognition 2013
- Fine-Grained Crowdsourcing for Fine-Grained Recognition 2013
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DIFFERENTIAL CONNECTIVITY WITHIN THE PARAHIPPOCAMPAL PLACE AREA
MIT PRESS. 2013: 146-146
View details for Web of Science ID 000317030500588
- Discovering Object Functionality 2013
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NATURAL STIMULI ACQUIRE BASIC-LEVEL ADVANTAGE IN OBJECT-SELECTIVE CORTEX
MIT PRESS. 2013: 205-206
View details for Web of Science ID 000317030501156
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Automatic basic-level object and scene categorization
PSYCHOLOGY PRESS. 2012: 1028-1031
View details for DOI 10.1080/13506285.2012.726470
View details for Web of Science ID 000310949900008
- Web Image Prediction Using Multivariate Point Processes 2012
- Shifting Weights: Adapting Object Detectors from Image to Video 2012
- Crowdsourcing Annotations for Visual Object Detection 2012
- Action Recognition with Exemplar Based 2.5D Graph Matching 2012
- Efficient Euclidean Projections onto the Intersection of Norm Balls 2012
- Recognizing Human Actions in Still Images by Modeling the Mutual Context of Objects and Human Poses 2012
- Object-centric spatial pooling for image classification 2012
- Online Detection of Unusual Events in Videos via Dynamic Sparse Coding 2011
- Classifying Actions and Measuring Action Similarity by Modeling the Mutual Context of Objects and Human Poses 2011
- Distributed cosegmentation vis submodular optimization on anisotropic diffusion 2011
- Large-Scale Category Structure Aware Image Categorization 2011
- Hierarchical Semantic Indexing for Large Scale Image Retrieval 2011
- Simple line drawings suffice for functional MRI decoding of natural scene categories 2011
- ReV ReVision: Automated Classification, Analysis and Redesign of Chart Imagesision: Automated Classification, Analysis and Redesign of Chart Images 2011
- Fast and Balanced: Efficient Label Tree Learning for Large Scale Object Recognition 2011
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MicroRNA-210 as a Novel Therapy for Treatment of Ischemic Heart Disease
LIPPINCOTT WILLIAMS & WILKINS. 2010: S124-S131
Abstract
MicroRNAs are involved in various critical functions, including the regulation of cellular differentiation, proliferation, angiogenesis, and apoptosis. We hypothesize that microRNA-210 can rescue cardiac function after myocardial infarction by upregulation of angiogenesis and inhibition of cellular apoptosis in the heart.Using microRNA microarrays, we first showed that microRNA-210 was highly expressed in live mouse HL-1 cardiomyocytes compared with apoptotic cells after 48 hours of hypoxia exposure. We confirmed by polymerase chain reaction that microRNA-210 was robustly induced in these cells. Gain-of-function and loss-of-function approaches were used to investigate microRNA-210 therapeutic potential in vitro. After transduction, microRNA-210 can upregulate several angiogenic factors, inhibit caspase activity, and prevent cell apoptosis compared with control. Afterward, adult FVB mice underwent intramyocardial injections with minicircle vector carrying microRNA-210 precursor, minicircle carrying microRNA-scramble, or sham surgery. At 8 weeks, echocardiography showed a significant improvement of left ventricular fractional shortening in the minicircle vector carrying microRNA-210 precursor group compared with the minicircle carrying microRNA-scramble control. Histological analysis confirmed decreased cellular apoptosis and increased neovascularization. Finally, 2 potential targets of microRNA-210, Efna3 and Ptp1b, involved in angiogenesis and apoptosis were confirmed through additional experimental validation.MicroRNA-210 can improve angiogenesis, inhibit apoptosis, and improve cardiac function in a murine model of myocardial infarction. It represents a potential novel therapeutic approach for treatment of ischemic heart disease.
View details for DOI 10.1161/CIRCULATIONAHA.109.928424
View details for Web of Science ID 000282294800019
View details for PubMedID 20837903
- Objects as Attributes for Scene Classification 2010
- Efficient Extraction of Human Motion Volumes by Tracking 2010
- Building and Using a Semantivisual Image Hierarchy 2010
- Object Bank: A High-Level Image Representation for Scene Classification and Semantic Feature Sparsification 2010
- Large Margin Learning of Upstream Scene Understanding Models 2010
- Learning object categories from Internet image searches 2010
- What does classifying more than 10,000 image categories tell us? 2010
- Connecting Modalities: Semi-supervised Segmentation and Annotation of Images Using Unaligned Text Corpora 2010
- Attribute learning in large-scale datasets 2010
- Image Segmentation with Topic Random Fields 2010
- Exploring Functional Connectivity of the Human Brain using Multivariate Information Analysis 2009
- Learning a dense multi-view representation for detection, viewpoint classification and synthesis of object categories 2009
- A Multi-View Probabilistic Model for 3D Object Classes 2009
- ImageNet: A Large-Scale Hierarchical Image Database 2009
- Towards Total Scene Understanding:Classification, Annotation and Segmentation in an Automatic Framework 2009
- OPTIMOL: automatic Online Picture collecTion via Incremental MOdel Learning 2009
- Hierarchical Mixture of Classification Experts Uncovers Interactions between Brain Regions 2009
- Simultaneous Image Classification and Annotation 2009
- View synthesis for recognizing unseen poses of object classes. 2008
- Unsupervised learning of human action categories using spatial-temporal words. 2008
- Towards scalable dataset construction: An active learning approach. 2008
- Extracting Moving People from Internet Videos. 2008
- Spatial-temporal correlations for unsupervised action classification. 2008
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Oxidative damage to the endoplasmic reticulum is implicated in ischemic neuronal cell death
ACADEMIC PRESS INC ELSEVIER SCIENCE. 2004: 61-61
View details for Web of Science ID 000224022300117
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Temporal profile of angiogenesis and expression of related genes in the brain after ischemia
LIPPINCOTT WILLIAMS & WILKINS. 2004: E250-E250
View details for Web of Science ID 000221676600572
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Induction of grp78 by ischemic preconditioning reduces endoplasmic reticulum stress and prevents delayed neuronal cell death
LIPPINCOTT WILLIAMS & WILKINS. 2004: E249-E249
View details for Web of Science ID 000221676600565
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Comparison of methods for detection of mutations in the BRCA1 gene.
CELL PRESS. 2001: 440-440
View details for Web of Science ID 000171648901507