Stanford Biomaterials and Advanced Drug Delivery Laboratory (bioADD) is a cutting edge research facility located at Stanford University. Today’s problems in drug design require complex answers to achieve effective delivery and treatment. The Stanford BioADD Laboratory helps to solve these problems with advanced modern technology and innovative solutions. Specializing in the creation of biomaterials and drug delivery agents, the laboratory lends its expertise toward designing drug formulations and developing smart materials for biomedical applications.
Description of Services
Formulation:
- Developing formulations for drug delivery systems
- Development and testing of various types of pharmaceutical and biopharmaceutical formulations; suspensions, injectable, immediate release and controlled drug delivery systems - extended release tablets and transdermal patches
Biophysical characterization of drug molecules:
- Study of interactions between proteins and small molecules
- Linking pharmaceutical compounds to biopolymers for sustained/targeted delivery
- Distribution of drug molecules in a film/patch and gels formulations by Raman mapping
- Self-assembly and aggregation of peptide, proteins and other biomolecules
- Morphological and surface characterization by AFM, TEM, SEM
- Conformational studies on peptides and proteins
- Mapping drug molecules in tissue samples by MALDI
Multi-step organic synthesis:
- Synthesis, purification, and characterization of small molecule compounds
- Scaled up large scale of intermediates and small molecule compounds and libraries synthesis
- Microwave assisted chemistry and application of this tool in multi-step and parallel synthesis of diversified chemicals
- Synthesis, purification, and characterization of natural and unusual amino acid derivatives and peptides via solution and solid phase methods
Materials synthesis Characterization:
- Studying polymorphic conversions of potential new drug substances in different matrices of excipients and polymers
- Developing analytical methods for testing of polymorphic purity of various drug substances
- Physicochemical characterization of pharmaceuticals and biopharmaceuticals protein binding studies
- Characterization of reference standards
Bioanalytical division:
- Analytical method development, optimization, and validation
- Development of quantitative methods for evaluating performance and efficacy of various types of drug products;development of impurity, content uniformity, strength, identity, residual solvents, water content, release rate, chiral purity assays
- Thermodynamic solubility, pH solubility, moisture sorption, skin flux, slurry amplification, compatibility, stability, forced degradation studies, dissolution testing, measurements of pKa, logP, surface area, porosity and density
- Supporting lead optimization process and preclinical development of potential new drug product candidates
Selected References
Vascular anastomosis using controlled phase transitions in poloxamer gels. Chang EI, Galvez MG, Glotzbach JP, Hamou CD, El-ftesi S, Rappleye CT, Sommer KM, Rajadas J, Abilez OJ, Fuller GG, Longaker MT, Gurtner GC. Nat Med. 2011 Aug 28;17(9):1147-52. PubMedID: 21873986.
Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling. Wong VW, Rustad KC, Akaishi S, Sorkin M, Glotzbach JP, Januszyk M, Nelson ER, Levi K, Paterno J, Vial IN, Kuang AA, Longaker MT, Gurtner GC. Nat Med. 2011 Dec 11;18(1):148-52. PubMedID: 22157678.
Efficient gene delivery of primary human cells using peptide linked polyethylenimine polymer hybrid. Dey D, Inayathullah M, Lee AS, LeMieux MC, Zhang X, Wu Y, Nag D, De Almeida PE, Han L, Rajadas J, Wu JC. Biomaterials. 2011; 32(20):4647-58. PubMedID: 21477858.
