Current and Future Maternal-Fetal Medicine Studies

Investigator

Initiated Studies

Invest.

Screened / Enrolled

Target

Status

ACCRETA

Clinical and Molecular Characterization of Placenta Accreta: a Prospective, Observational Study to Establish a Database and Tissue Bank

Lyell

50 enrolled

Ongoing (200 +)

Ongoing

Additional Collaboration with UCSF and Utah Consortium

AFB

Amniotic fluid banking

Aziz

Chueh

284 enrolled

150-250

annually

Enrollment paused for interim analyses, IRB still open

BIOMARKER

Noninvasive fetal and pregnancy biomarker discovery project

Blumenfeld

Quake

El-Sayed

136 enrolled

*Starting segmented enrollment for gastroschisis as model for selected indications

300

3 years

Ongoing

3 gastroschisis

1 TTTS enrolled

Enrollment at Stanford paused due to staffing shortage

CERVIX and PRE-TERM BIRTH

Novel Assessment of the Cervix

Blumenfeld

12 enrolled

15

2 years

Ongoing

INDOCIN

Indocin vs. nifedipine for preterm labor tocolysis – A prospective, double-blind, randomized clinical trial

Blumenfeld

Pullen

Langen

El-Sayed

Lyell

29 enrolled

110

Ongoing, Enrollment at Stanford paused due to staffing shortage

PROBIOTICS

Oral probiotic supplementation and Group B Streptococcus rectovaginal colonization in pregnant women: a randomized double-blind placebo-controlled trial. IPC grant awarded

Aziz

Taslimi

Klikoff

Ehrlich

Benitz

Norton

264 enrolled

(97 Stanford)

(167 Santa Cruz)

372

Ongoing, Enrollment at Stanford paused due to staffing shortage

STRESS and PTL

Stress and preterm labor in multiple gestations

Lyell

Koopman

Blumenfeld

47 enrolled

120

5 years

Ongoing

Enrollment paused due to staffing shortage

PROLENE

Comparison of Staples versus Nonabsorbable Subcuticular Prolene Suture for Skin Closure in Cesarean Deliveries

Baumbusch

Aziz

Do

13

100

3 years

Added third arm, approved 9/2014

On Hold due to staffing shortage

BACTERIURIA

Maternal and Neonatal Morbidity among Women with Urinary Tract Infections and Bacteriuria during pregnancy: Comparison of Pan-Sensitive and Drug-Resistant Uropathogens

Aziz

O’Malley

Banaei

Ongoing, Retrospective Review

NON-IMMUNE HYDROPS:

Classification and predictors of outcomes

Retrospective study with Texas Children’s

Ness

Chart Review, finalizing data

PTB SUBTYPES IN TWINS VS SINGLETONS

State Database study

Ness

Database Review, finalizing data

UTERINE RUPTURE

State Database study

Ness

Database Review, will submit to SMFM 2015 deadline

GASTROSCHISIS

Gastroschisis retrospective data base

Blumenfeld      El-Sayed             Hintz

Chart Review