Kyle Lampe

Professional Education

Internet Links

• Heilshorn Biomaterials Group

Current Research Interests

Neurodegenerative diseases and injuries to the central nervous system such as stroke and spinal cord injury take a considerable toll on the worldwide population. While neural stem cell (NSC) transplantation shows great promise for therapies in this regard, current transplant strategies are limited and insufficient. By encapsulating adult NSCs in our novel protein-based biomaterials we hope to develop strategies for: expanding these cells in vitro, specifically controlling cell differentiation, providing cells with protection during the implantation process, and localizing cell delivery upon transplantation. These materials have been engineered with neural tissue-appropriate mechanical properties and specific functions including cell-mediated degradation, adhesive site presentation, injectibility, and enhanced drug delivery. With these tools, we hope to learn more about how materials impact NSC fate (differentiation and self-renewal), viability, and functionality as well as develop CNS injury models to assess protein hydrogel utility in vivo.

Publications

• The administration of BDNF and GDNF to the brain via PLGA microparticles patterned within a degradable PEG-based hydrogel: Protein distribution and the glial response. Lampe KJ, Kern DS, Mahoney MJ, Bjugstad KB. J Biomed Mater Res A. 2011; 96 (3): 595-607
• Biocompatibility of poly(ethylene glycol)-based hydrogels in the brain: an analysis of the glial response across space and time. Bjugstad KB, Lampe K, Kern DS, Mahoney M. J Biomed Mater Res A. 2010; 95 (1): 79-91
• Effect of macromer weight percent on neural cell growth in 2D and 3D nondegradable PEG hydrogel culture. Lampe KJ, Mooney RG, Bjugstad KB, Mahoney MJ. J Biomed Mater Res A. 2010; 94 (4): 1162-71
• Impact of degradable macromer content in a poly(ethylene glycol) hydrogel on neural cell metabolic activity, redox state, proliferation, and differentiation. Lampe KJ, Bjugstad KB, Mahoney MJ. Tissue Eng Part A. 2010; 16 (6): 1857-66
• Impact of lactic acid on cell proliferation and free radical-induced cell death in monolayer cultures of neural precursor cells. Lampe KJ, Namba RM, Silverman TR, Bjugstad KB, Mahoney MJ. Biotechnol Bioeng. 2009; 103 (6): 1214-23