Highlights of Current CTRU Studies

Highlights of Current CTRU Studies include:

• Evaluating Safety, Tolerability, Pharmacokinetics, pharmacodynamics of Orally Administered CYT387 in Primary Myelofibrosis, Post Polycythemia Vera or Post Essential Myelofibrosis
• Patients with relapsed or refractory B-cell non-Hodgkin’s lymphomas and chronic lymphocytic leukemia.
• Study of Gemcitabine, Carboplatin and Poly (ADP-Ribose) Polymerase (PARP) Inhibitor BSI-201 in the Neoadjuvant Treatment of Triple Negative Breast Cancer
• Addition of the long-acting glucagon-like peptide-1, liraglutide, to a calorie-restricted diet augments weight loss, and decreases risk of type 2 diabetes and cardiovascular disease in older, overweight/obese, pre-diabetic individuals
• Oral Peanut Immunotherapy in Peanut-Allergic Patients
• U19 2009_Project 1: B-cell Immunity to Influenza and Tech. Development, Project 1: Measuring the Immunome: Genomic Approaches to B-cell Repertoire
• U19 2009_Project 2: T-cell and General Immune Responses to Influenza, Project 3: Single-cell Phospho-protein Signaling Analysis of the Response to Influenza Vaccination, Technical Development Project 1: Measuring the Immunome: Genomic Approaches to B-cell Repertoire
• Protective mechanisms against respiratory viruses and T cell dependent production of interferon-gamma by natural killer cells in response to influenza A virus
• Using nutrient dense plant-based foods to increase the total and LDL cholesterol lowering effect of a low fat diet
• Studies of metabolic markers to identify overweight individuals who are insulin resistant
• Idiotype vaccination studies in patients with follicular lymphoma
• Neuroimaging and Neurodevelopmental Outcome
• New therapeutic approaches in colorectal cancers
• Therapeutic Manipulation of the NOS Pathway in Peripheral Arterial Disease
• The Aging Kidney after Contralateral Nephrectomy
• A Phase I/II Study of Intratumoral Injection of CpG7909, a TLR Agonist, Combined with Local Radiation in Recurrent Low Grade Lymphomas