Ductal Carcinoma in Situ of the Breast
High Grade Ductal Carcinoma In Situ
Diagnostic Criteria (Van Nuys)
- High grade cytologic features are required, with or without tumor cell (comedo) necrosis
-
Nuclei >3x size of a RBC (>15 microns)
- Nuclei pleomorphic with coarse, clumped chromatin
- Nucleoli prominent, enlarged
- Mitotic figures numerous, often atypical
- Necrosis almost universal but not required
- No architectural requirement
- No size requirement
- Variant architectural types