Plasmacytoma
Supplemental Studies
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Flow cytometry or immunohistochemical studies to establish plasma cell differentiation and light chain monoclonality, as for plasma cell myeloma
- Hematolymphoid markers
- CD45 absent or dim in >99%
- B cell and plasma cell markers
- CD138 >99%
- CD38 >99%
- CD79a, most
- CD20 variable, often absent
- CD19 variable, often absent
- CD56 up to 80% -- aberrant antigen
- Cytoplasmic kappa or lambda light chain by flow cytometry, in situ hybridization, or immunohistochemistry
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Useful Laboratory Tests
- Serum or urine protein electrophoresis, immunofixation, light chain quantification
- Quantitation and typing of monoclonal immunoglobulin / light chain
- Serum free light chain analysis may be required to demonstrate clonal light chains
- These studies may be used to
- Establish presence of a monoclonal plasma cell population
- Quantitation helps subtype the plasma cell dyscrasia (i.e. >3g/dL serum monoclonal protein is a major criterion for myeloma)
- Track disease burden over time
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