Locus Overview
- Standard Name
- SIR4 1
- Systematic Name
- YDR227W
- SGD ID
- S000002635
- Aliases
- ASD1 , STE9 , UTH2
- Feature Type
- ORF , Verified
- Description
- SIR protein involved in assembly of silent chromatin domains; silent information regulator (SIR) along with SIR2 and SIR3; involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan 2 3 4
- Name Description
- Silent Information Regulator 1
Sequence
The S. cerevisiae Reference Genome sequence is derived from laboratory strain S288C. Download DNA or protein sequence, view genomic context and coordinates. Click "Sequence Details" to view all sequence information for this locus, including that for other strains.
Analyze Sequence
S288C only
ATCC/WashU Clones | BLASTN | BLASTP | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species
BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Fungal Alignment | Synteny Viewer
S288C vs. other strains
Protein
Basic information about the protein. Click "Protein Details" for further information about the protein such as abundance data, domains, shared domains with other proteins, protein sequence retrieval for various strains, sequence-based physico-chemical proterties, protein modification sites sites, and external identifiers for the protein.
- Length (a.a.)
- 1358
- Mol. Weight (Da)
- 152084.6
- Isoelectric Point
- 9.63
Gene Ontology
GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes.
View computational annotations
Molecular Function
- Manually Curated
Biological Process
Cellular Component
- Manually Curated
Phenotype
Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided. Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes.
Classical Genetics
- gain of function
- null
- conditional
- overexpression
- null
- filamentous growth: decreased
- invasive growth: absent
- killer toxin resistance: increased
- mating response: absent
- protein transport: abnormal
- resistance to acetic acid: increased
- resistance to arsenite(3-): decreased
- resistance to bleomycin: increased
- resistance to caffeine: decreased
- resistance to cicloheximide: decreased
- resistance to edelfosine: increased
- resistance to fluconazole: increased
- resistance to mycophenolic acid: increased
- resistance to pentachlorophenol: decreased
- resistance to pyocyanin: decreased
- telomere length: decreased
- viable
- overexpression
Large-scale Survey
Interaction
Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference, as well as other experimental details. Click "Interaction Details" to view all interaction annotations and evidence for this locus, including an interaction visualization.
233 total interactions for 94 unique genes
Physical Interactions
- Affinity Capture-MS: 22
- Affinity Capture-RNA: 2
- Affinity Capture-Western: 45
- Biochemical Activity: 4
- Co-crystal Structure: 2
- Co-localization: 5
- Co-purification: 5
- PCA: 1
- Reconstituted Complex: 23
- Two-hybrid: 63
Genetic Interactions
- Dosage Rescue: 9
- Phenotypic Enhancement: 9
- Phenotypic Suppression: 11
- Synthetic Growth Defect: 12
- Synthetic Rescue: 20
Regulation
The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. This evidence includes data generated through high-throughput techniques. Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus.
- Regulators
- 3
- Targets
- 0
Expression
Expression data are derived from records contained in the Gene Expression Omnibus (GEO), and are first log2 transformed and normalized. Referenced datasets may contain one or more condition(s), and as a result there may be a greater number of conditions than datasets represented in a single clickable histogram bar. The histogram division at 0.0 separates the down-regulated (green) conditions and datasets from those that are up-regulated (red). Click "Expression Details" to view all expression annotations and details for this locus, including a visualization of genes that share a similar expression pattern.
Summary Paragraph
A summary of the locus, written by SGD Biocurators following a thorough review of the literature. Links to gene names and curated GO terms are included within the Summary Paragraphs.
Last Updated: 1999-09-01
Literature
All manually curated literature for the specified gene, organized into topics according to their relevance to the gene (Primary Literature, Additional Literature, or Review). Click "Literature Details" to view all literature information for this locus, including shared literature between genes.
