Courses

Diseases of the nervous system. First lecture of each week focuses on the clinical, epidemiological and behavioral aspects of a selected disease or syndrome. Second lecture exposes the cell biological, electrophysiological, biochemical and/or molecular biological processes that underlie each disease presented. Instructors maintain some flexibility in the diseases chosen for elucidation, but students can expect those covered to range from the relatively straightforward, for example Multiple Sclerosis (MS) or Amyotrophic Lateral Sclerosis (ALS), to the more complex, for example, Schizophrenia or Obsessive Compulsive Disorder (OCD). 3 units for lecture and discussion only; 4 units includes a paper. Prerequisite: Biology or Human Biology core. Terms: Win| Units: 3| Grading: Medical Option (Med-Ltr-CR/NC)

Instructors: Madison (PI), TBD

Students undertake investigations sponsored by individual faculty members. Prerequisite: consent of instructor.

Readings of immunological literature. Classic problems and emerging areas based on primary literature. Student and faculty presentations. Prerequisite: IMMUNOL 201/MI 211.

Terms: Spr | Units: 3 | Grading: Medical Option (Med-Ltr-CR/NC)

Instructors: Garcia, K. (PI)

Advanced seminar. Findings and implications of behavioral genetics as applied to invertebrate and vertebrate model systems. Topics include biological clocks, and sensation and central pattern generators. Relevant genetic techniques and historical perspective. Student presentation.

Terms: Spr | Units: 4 | Grading: Medical Option (Med-Ltr-CR/NC)

Instructors: Clandinin, T. (PI); Goodman, M. (PI)

For Ph.D. students. Current research on cell structure, function, and dynamics. Topics include complex cell phenomena such as cell division, apoptosis, compartmentalization, transport and trafficking, motility and adhesion, differentiation, and multicellularity. Current papers from the primary literature. Prerequisite for advanced undergraduates: BIO 129A,B, and consent of instructor.

Terms: Win | Units: 2-5 | Grading: Medical Option (Med-Ltr-CR/NC)

Instructors: Kopito, R. (PI); Nachury, M. (PI); Pfeffer, S)

Survey of instruments which use light and other radiation for analysis of cells in biological and medical research. Topics: basic light microscopy through confocal fluorescence and video/digital image processing. Lectures on physical principles; involves partial assembly and extensive use of lab instruments. Lab. Prerequisites: some college physics, Biology core.

Terms: Spr | Units: 3 | Grading: Medical Option (Med-Ltr-CR/NC)

Instructors: Lewis, R. (PI); Smith, S. (PI)

Laboratory and lectures. Advanced microscopy and imaging, emphasizing hands-on experience with state-of-the-art techniques. Students construct and operate working apparatus. Topics include microscope optics, Koehler illumination, contrast-generating mechanisms (bright/dark field, fluorescence, phase contrast, differential interference contrast), and resolution limits. Laboratory topics vary by year, but include single-molecule fluorescence, fluorescence resonance energy transfer, confocal microscopy, two-photon microscopy, and optical trapping. Limited enrollment. Recommended: basic physics, Biology core or equivalent, and consent of instructor.

Terms: Spr | Units: 4 | Grading: Letter or Credit/No Credit

Instructors: Block, S. (PI); Smith, S. (PI); Stearns, T. (PI)

Open to graduate and medical students, and advanced undergraduates. Dynamic aspects of cell behavior and function, including cellular energetics, homeostasis, heterogeneity of membranes, structure and function of organelles, solute and water transport, signaling and motility. Emphasis is on the principles of how coupling of molecular processes gives rise to essential functions at the cellular level. Mathematical models of cell function. Student presentations.

Terms: Aut | Units: 4 | Grading: Medical Option (Med-Ltr-CR/NC)

Instructors: Goodman, M. (PI); Maduke, M. (PI)

Prerequisite: consent of instructor.

Terms: Aut, Win, Spr, Sum | Units: 1-18 | Repeatable for credit | Grading: Medical Option (Med-Ltr-CR/NC)

Provides an opportunity for student and faculty interaction, as well as academic credit and financial support, to medical students who undertake original research. Enrollment is limited to students with approved projects.

Terms: Aut, Win, Spr, Sum | Units: 4-18 | Repeatable for credit | Grading: Medical School MD Grades

Students undertake investigations sponsored by individual faculty members. Research fields include endocrinology, neuroendocrinology, and topics in molecular and cellular physiology. Prerequisite: consent of instructor. (Staff)

Terms: Aut, Win, Spr, Sum | Units: 1-18 | Repeatable for credit | Grading: Medical Option (Med-Ltr-CR/NC)

Terms: Aut, Win, Spr, Sum | Units: 0 | Repeatable for credit | Grading: TGR

Terms: Aut, Win, Spr, Sum | Units: 0 | Repeatable for credit | Grading: TGR