Diffuse Large B Cell Lymphoma
Variant: Anaplastic Variant of Diffuse Large B Cell Lymphoma
- Previously included in Anaplastic Large Cell Lymphoma (ALCL)
- ALCL is now restricted to T lineage (by phenotype or genotype) lymphomas
- May share several featuares of ALCL
- Very large cells with markedly pleomorphic nuclei
- May resemble Reed-Sternberg cell
- Sinusoidal pattern of growth
- CD30 expression variable
- EMA 7/22 positive
- Distinguishing features from ALCL
- B lineage
- Lack of ALK staining
- Age median 54 years more like large B cell lymphoma than ALCL
- Behavior same as diffuse large B cell lymphoma
- Note that these are distinct from ALK positive large B cell lymphoma
