Diffuse Large B Cell Lymphoma
Variant: T Cell Rich B Cell Lymphoma / Histiocyte Rich B Cell Lymphoma
- Can be considered as a spectrum
- Large atypical cells make up less than 10% of population
- May have any features of usual large B cell lymphoma
- May resemble Reed-Sternberg cells
- B lineage
- Neoplastic cells may be missed on flow analysis
- CD30 0-8%
- CD15 0-15%
- EMA 0-60%
- Reactive T cells predominante
- Small to medium sized
- Nuclei may be round or irregular
- No increase in CD57 positive cells
- Histiocytes may be numerous
- May be associated with conventional large B cell lymphoma pattern
- May be concurrent or metachronous
- Same behavior as conventional diffuse large B cell lymphoma, stage for stage
- Over half present as stage III or IV