KSHV-associated Germinotropic Lymphoproliferative Disorder
Definition
- KSHV (HHV8) associated lymphoproliferative disorder with plasmablasts involving germinal centers
Diagnostic Criteria
- Plasmablastic cytology
- 1 or 2 prominent nucleoli
- Moderate amount of amphophilic cytoplasm
- Plasmablasts preferentially involve germinal centers
- Partial or complete involvement
- Clusters or aggregates
- Plasmablasts HHV8 (KSHV) and EBV positive
- Remainder of node not involved
- Germinal centers show no features of Castleman disease
- Prominent interfollicular plasmacytosis
- No interfollicular plasmablasts
- One published report of three patients by Du et al.
Yasodha Natkunam MD PhD
Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342
Original posting:: May 1, 2006
