Pyothorax Associated Lymphoma
Definition
- Pleural based lymphoma associated with chronic pleural inflammation
Diagnostic Criteria
- Large cell lymphoma involving pleura
- Arises in setting of chronic pyothorax
- Tumor mass typically present
- May involve lung, chest wall or pericardium
- Abundant basophilic cytoplasm
- Most cases immunoblastic
- EBV positive at least 70% of cases
- Most reported cases B lineage
- Infrequent T lineage or biophenotypic cases reported
- HHV8 negative in all but one reported case
Yasodha Natkunam MD PhD
Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342
Original posting:: May 1, 2006
