Polypoid/Papillary Cystitis
Definition
- Polypoid reactive urothelial lesion
Diagnostic Criteria
- Predominantly composed of frond-like papillae
- Stromal edema
- Stromal acute and/or chronic inflammation
- Predominantly broad based fronds
- Thin or branching stalks unusual
- Lined by normal to thickened transitional epithelium
- Reactive atypia may be present
- Uniform increase in nuclear size
- Single uniform nucleoli
- Mitotic figures may be present
- No nuclear hyperchromatism or pleomorphism
- (Umbrella cells, as always, are exceptions to this rule)
- Arises in a setting of chronic irritation
- Older lesions may have more fibrotic, thinner stalks
- May not always be separable from fibroepithelial polyp
- Areas of edematous, inflammed, broad fronds generally present
Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342
Original posting/updates: 10/20/12
