Apocrine Adenosis of the Breast
Definition
- A haphazard proliferation of bland glands with apocrine differentiation
Alternate/Historical Names
- Adenomyoepithelial Adenosis
- Secretory Adenosis
Diagnostic Criteria
- Variably sized open round glands
- Eosinophilic granular secretion
- Lumenal cells show apocrine differentiation
- Tall columnar
- Granular eosinophilic cytoplasm
- Bland, basal nuclei
- GCDFP15 positive
- Occasional squamous metaplasia
- Basal myoepithelial cells uniformly present
- Flattened
- Cytologically bland
- Myoepithelial markers positive
- Poorly circumscribed
- Predominantly scattered through adipose tissue
- Scant stroma
- Most cases merge with adenomyoepithelioma
Richard L Kempson MD
Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342
Original posting:: May 15, 2006
