Glycogen Rich Clear Cell Carcinoma of the Breast
Definition
- Breast carcinoma exhibiting predominantly clear cytoplasm due to glycogen
Diagnostic Criteria
- At least 90% of the neoplastic cells have abundant clear cytoplasm due to glycogen
- PAS positive, diastase sensitive in most cases
- Processing may remove glycogen
- Minor component of eosinophilic granular cytoplasm may be present
- May suggest apocrine differentiation
- Scant amounts of intracellular mucin may be seen in some cases
- PAS positive, diastase sensitive in most cases
- Growth pattern is usually that of usual infiltrating ductal carcinoma
- Other patterns reported include lobular, tubular and medullary
- Intraductal clear cell component may be present
Richard L Kempson MD
Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342
Original posting:: May 1, 2006
