Ulcerative Jejunoileitis
Definition
- Chronic idiopathic ulcerative process of the small intestine associated with celiac disease and enteropathy-type T cell lymphoma
Alternate / Historic names
- Chronic ulcerative jejunitis
- Non-granulomatous ulcerative jejunitis
- Ulcerative enteritis
- Ulcerative jejunitis
Diagnostic Criteria
- Multiple ulcers in jejunum and/or ileum
- Usually transversely oriented
- Variable depth
- May perforate
- Mixed inflammatory infiltrate in ulcers
- Granulomas not seen
- Scarring may lead to strictures
- Villous atrophy of surrounding mucosa
- Usually arises in the setting of refractory celiac disease or villous atrophy of unknown type
- Diagnosis of celiac disease frequently made concurrently with the ulcers
- May represent a precursor or early stage of enteropathy type T cell lymphoma
- Most cases have a clonal T cell population
- Subsequent lymphomas express the same T cell receptor gene rearrangement as seen in the ulcerative jejunoileitis
Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342
Original posting : November 11, 2009
