Juvenile Polyp of the Gastrointestinal Tract
Definition
- Gastrointestinal polyp with prominent cystically dilated glands and inflammatory stroma
Alternate/historical Names
- Juvenile hamartomatous polyp
- Juvenile type polyp
Covered Separately
Diagnostic Criteria
- Usually smoothly spherical pedunculated polyp
- Some in Juvenile Polyposis syndrome are multilobated and/or papillary
- Mucous retention cysts
- Prominent cystically dilated glands
- Lined by cuboidal to columnar mucinous cells
- Other glands may be irregularly dilated
- Dilation may be less prominent in small, early polyps
- Abundant inflamed stroma
- Lymphoplasmacytic infiltrate
- Eosinophils may be prominent
- May be edematous
- Surface may be eroded
- No smooth muscle component
- Dysplasia and carcinoma are very rare in sporadic polyps
- Sporadic polyps confined to colon and rectum
- May be multiple (usually 1-3)
- ≥5 polyps or extra-colorectal location may indicate Juvenile Polyposis syndrome
- No clinically useful stains
Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342
Original posting/updates: 12/27/09, 11/12/11
