Neuroblastoma Associated Renal Cell Carcinoma
Definition
- Distinctive renal carcinoma associated with history of neuroblastoma
Diagnostic Criteria
- Carcinomas have been reported to arise in the kidneys of patients with a history of neuroblastoma
- Most present about 10 years post diagnosis of neuroblastoma
- Most are post-treatment but rare cases reported without radiation or chemotherapy
- Predominantly composed of oncocytic cells
- Abundant eosinophilic cytoplasm
- Mild to moderate atypia
- Irregular nuclei with prominent nucleoli
- Papillary and solid growth patterns
- One reported case of infiltrating cords with desmoplasia
- Other types of conventional renal cell carcinoma may also be seen
- Clear cell, papillary and Xp11 translocation carcinomas have been reported
John P Higgins MD
Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342
Original posting:: January 24, 2011
