Lymphoepithelial Cyst of the Pancreas

Definition

Pancreatic cystic lesion lined by squamous epithelium with surrounding lymphoid stroma

Unilocular or multilocular lesion
- Generally filled with keratinous debris
- May protrude from pancreatic surface
Cysts lined by mature keratininzing squamous epithelium
- Occasional cuboidal or transitional appearing areas
- Rarely focal goblet or sebaceous cells
- No skin adnexae
Uniform, dense surrounding lymphoid tissue
- Frequently with germinal centers
- May have peripheral space suggestive of subcapsular sinus
- No acute inflammation
- Occasional cases with lymphoepithelial-like lesions in surrounding lymphoid tissue
Surrounding pancreatic tissue normal or focally atrophic

Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342

Original posting : 1/4/08
Updates : 4/26/09, 11/18/12