Monoclonal Gammopathy of Undetermined Significance
Definition
- Serum monoclonal immunoglobulin (M-protein) in absence of plasma cell myeloma or B cell lymphoproliferative disorder
Alternate/Historical Names
- MGUS
Diagnostic Criteria
- Presence of serum M-protein <3 g/dL
- Bone marrow clonal plasma cells present but <10%
- No renal insufficiency, anemia, hypercalcemia, lytic bone lesions, or other organ/tissue damage
- If any of above criteria are exceeded, classify as plasma cell myeloma
- If low grade B cell lymphoma is present, classify with the lymphoma
Dita Gratzinger MD PhD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342
Initial posting / updates: 9/1/07, 4/14/10
