Enteropathy-Type T Cell Lymphoma
Definition
- T cell lymphoma involving the gastrointestinal tract, expressing cytotoxic granule associated proteins, frequently associated with enteropathic changes
Alternate/Historical Names
- Intestinal T cell lymphoma
- Enteropathy associated T cell lymphoma
- Malignant histiocytosis of the intestine
Diagnostic Criteria
- Forms an ulcerated intestinal mass
- Wide range of histologic appearances
- Ranges from regular small to medium size cells to large pleomorphic cells
- Frequent inflammatory cells including histiocytes and eosinophils
- Cytotoxic T lineage
- Frequently associated with enteropathic changes
- Adjacent epithelium abnormal in 75% of cases
- Villous atrophy with crypt hyperplasia
- Intraepithelial lymphocytes
- Lamina propria lymphoplasmacytic infiltrate
Dita Gratzinger MD PhD
Yasodha Natkunam MD PhD
Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342
Initial posting : September 1, 2007
