Chronic Graft versus Host Disease (GVHD) of Gastrointestinal Tract
Definition
- Attack by engrafted hematopoietic cells and their progeny on host gastrointestinal tissues in at least 100 days post-transplant
Diagnostic Criteria
- Changes are nonspecific
- Submucosal fibrosis
- Architectural distortion
- Epithelial regeneration
- Apoptosis
- No grading scheme exists for chronic GI graft versus host disease
Neeraja Kambham MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342
Original posting : May 9, 2007
