Graft versus Host Disease (GVHD) of the Liver
Definition
- Attack by engrafted hematopoietic cells and their progeny on the host liver
Diagnostic Criteria
- Early phase
- Lymphoplasmacytic infiltration of portal tracts
- Damage to bile duct epithelium
- Cytoplasmic swelling and vacuolation
- Enlarged and overlapping nuclei (reactive epithelial atypia)
- Apoptosis
- Late phase
- Loss of bile ducts
- Increased fibrosis
Neeraja Kambham MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342
Original posting : May 9, 2007
