Systems Biology Research Group

About the Lab

Welcome to the Systems Biology Research Group at the University of California, San Diego. We study the complexity of cellular life using experimental and computational methods that span the genome to the phenotype. Developing, integrating, and applying new methods allow us to gain a systems view of life - from bacterial to human.

Job Openings

Researcher Snapshots:

My research combines bottom-up, first principle models and top-down, statistical approaches to understand the cellular biochemistry of human red cell metabolism. Using recently identified metabolite biomarkers to train models, we can infer the qualitative and quantitative behavior of other metabolites in the network. James Yurkovich, 4th Year PhD student.
I aim to integrate machine learning and sequencing data with constraint-based modeling to gain a better understanding of the systems architecture and regulatory networks of E. coli. Anand Sastry, 3rd year PhD student.
My research explores the role of enzyme promiscuity in mechanisms of evolution in E. coli. I utilize genome-scale model predictions to aid in the design of laboratory evolution experiments, and sequencing techniques to uncover the mechanisms behind adaptations to non-native carbon sources. Gabriela Guzman, final year of PhD.