The primate-specific noncoding RNA HPAT5 regulates pluripotency during human preimplantation development and nuclear reprogramming.

Durruthy-Durruthy J, Sebastiano V, Wossidlo M, Cepeda D, Cui J, Grow EJ, Davila J, Mall M, Wong WH, Wysocka J, Au KF, Reijo Pera RA. (2015) Nat Genet. Nov 23. doi: 10.1038/ng.3449. [PubMed]

The effect of microbial colonization on the host proteome varies by gastrointestinal location.

Lichtman JS, Alsentzer E, Jaffe M, Sprockett D, Masutani E, Ikwa E, Fragiadakis GK, Clifford D, Huang BE, Sonnenburg JL, Huang KC, Elias JE. (2015) ISME J.  Nov 17. doi: 10.1038/ismej.2015.187. [PubMed]

ETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formation.

Nady N, Gupta A, Ma Z, Swigut T, Koide A, Koide S, Wysocka J. (2015) Elife.  [PubMed]

Quantitative Imaging of Gut Microbiota Spatial Organization.

Earle KA, Billings G, Sigal M, Lichtman JS, Hansson GC, Elias JE, Amieva MR, Huang KC, Sonnenburg JL. (2015) Cell Host Microbe. [PubMed]

Quantitative Imaging of Gut Microbiota Spatial Organization.

Earle KA, Billings G, Sigal M, Lichtman JS, Hansson GC, Elias JE, Amieva MR, Huang KC, Sonnenburg JL. (2015) Cell Host Microbe. [PubMed]

HLTF’s Ancient HIRAN Domain Binds 3′ DNA Ends to Drive Replication Fork Reversal.

Kile AC, Chavez DA, Bacal J, Eldirany S, Korzhnev DM, Bezsonova I, Eichman BF, Cimprich KA. (2015) Mol Cell.  [PubMed]

Enhancer Divergence and cis-Regulatory Evolution in the Human and Chimp Neural Crest.

Prescott SL, Srinivasan R, Marchetto MC, Grishina I, Narvaiza I, Selleri L, Gage FH, Swigut T, Wysocka J. (2015) Cell. [PubMed]

Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma.

Ge X, Milenkovic L, Suyama K, Hartl T, Purzner T, Winans A, Meyer T, Scott MP. (2015) Elife. [PubMed]

Metaproteomic analysis adds a functional glimpse into host-microbe succession in an infant’s GI.

Elias JE.(2015) Proteomics. [PubMed]

A personalized medicine approach for Asian Americans with the aldehyde dehydrogenase 2*2 variant.

Gross ER, Zambelli VO, Small BA, Ferreira JC, Chen CH, Mochly-Rosen D. (2015) Annu Rev Pharmacol Toxicol. [PubMed]

Distinct transcriptional responses elicited by unfolded nuclear or cytoplasmic protein in mammalian cells.

Miyazaki Y, Chen LC, Chu BW, Swigut T, Wandless TJ. (2015) Elife [PubMed]

Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington’s disease.

Hwang S, Disatnik MH, Mochly-Rosen D.(2015) EMBO Mol Med [PubMed]

A Proteomic Strategy Identifies Lysine Methylation of Splicing Factor snRNP70 by the SETMAR Enzyme.

Carlson SM, Moore KE, Sankaran SM, Reynoird N, Elias JE, Gozani O. (2015) J Biol Chem. [PubMed]

Designs and sensing mechanisms of genetically encoded fluorescent voltage indicators.

St-Pierre F, Chavarha M, Lin MZ. (2015) Curr Opin Chem Biol. [PubMed]

Tunable and reversible drug control of protein production via a self-excising degron.

Chung HK, Jacobs CL, Huo Y, Yang J, Krumm SA, Plemper RK, Tsien RY, Lin MZ. (2015) Nat Chem Biol. [PubMed]

How Does the Xenopus laevis Embryonic Cell Cycle Avoid Spatial Chaos?

Gelens L, Huang KC, Ferrell JE Jr.(2015) Cell Rep. [PubMed]

Thinking big with small molecules.

Mruk K, Chen JK. (2015) J Cell Biol. [PubMed]

HLTF’s Ancient HIRAN Domain Binds 3′ DNA Ends to Drive Replication Fork Reversal.

Kile AC, Chavez DA, Bacal J, Eldirany S, Korzhnev DM, Bezsonova I, Eichman BF, Cimprich KA. (2015) Mol Cell. [PubMed]

Monitoring host responses to the gut microbiota.

Lichtman JS, Sonnenburg JL, Elias JE. (2015) ISME J.[PubMed] 

Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo.

Chen CH, Cruz LA, Mochly-Rosen D. (2015) Proc Natl Acad Sci [PubMed]

Mitochondrial Reactive Oxygen Species at the Heart of the Matter: New Therapeutic Approaches for Cardiovascular Diseases.

Kornfeld OS, Hwang S, Disatnik MH, Chen CH, Qvit N, Mochly-Rosen D. (2015) Circ Res. [PubMed]

Breaking bad: R-loops and genome integrity.

Sollier J, Cimprich KA. (2015) Trends Cell Biol. [PubMed]

Mitochondrial Reactive Oxygen Species at the Heart of the Matter: New Therapeutic Approaches for Cardiovascular Diseases.

Kornfeld OS, Hwang S, Disatnik MH, Chen CH, Qvit N, Mochly-Rosen D. (2015) Circ Res. [PubMed]

Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo.

Chen CH, Cruz LA, Mochly-Rosen D. (2015) Proc Natl Acad Sci [PubMed]

Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells.

Grow EJ, Flynn RA, Chavez SL, Bayless NL, Wossidlo M, Wesche DJ, Martin L, Ware CB, Blish CA, Chang HY, Reijo Pera RA, Wysocka J. (2015) Nature [PubMed]

Using light to shape chemical gradients for parallel and automated analysis of chemotaxis.

Collins SR, Yang HW, Bonger KM, Guignet EG, Wandless TJ, Meyer T. (2015)  Mol Syst Biol. [PubMed]

Thinking big with small molecules.

Mruk K, Chen JK. (2015) J Cell Biol. [PubMed]

Using SRM mass spectrometry to quantify nuclear protein abundance differences between adipose tissue depots of insulin-resistant mice.

Ota A, Kovary KM, Wu OH, Ahrends R, Shen WJ, Costa MJ, Feldman BJ, Kraemer FB,
Teruel MN. (2015) J Lipid Res. [PubMed]

A dynamic picture of protein behavior in cells

Teruel MN, Gu B, Zhao ML. (2015) Nat Biotechnol. [PubMed]

Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds.

Zalatan JG, Lee ME, Gilbert LA, Almeida R, Tsai JC, Whitehead EH, Weissman JS, Dueber JE, Qi LS*, Lim WA*. (2015) Cell. [PubMed] (* Co-corresponding author)

Small molecules enhance CRISPR genome editing in pluripotent stem cells

Yu C, Liu Y, Ma T, Xu S, Liu K, Zhang Y, La Russa M, Xie M, Ding S, Qi LS.(2015) Cell Stem Cell. [PubMed]

A Proteomic Strategy Identifies Lysine Methylation of Splicing Factor snRNP70 by SETMAR

Optochemical Dissection of T-box Gene-Dependent Medial Floor Plate Development.

Payumo AY, Walker WJ, McQuade LE, Yamazoe S, Chen JK. (2015) ACS Chem Biol. [PubMed]

Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo.

Chen CH, Cruz LA, Mochly-Rosen D. (2015) Proc Natl Acad Sci [PubMed]

Systematic Discovery of Human Gene Function and Principles of Modular Organization through Phylogenetic Profiling.

Dey G, Jaimovich A, Collins SR, Seki A, Meyer T. (2015) Cell Rep. [PubMed]

Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism.

Chiu CC, Yeh TH, Lai SC, Wu-Chou YH, Chen CH, Mochly-Rosen D, Huang YC, Chen YJ, Chen CL, Chang YM, Wang HL, Lu CS. (2015) Exp Neurol. [PubMed]

New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases.

Disatnik MH, Hwang S, Ferreira JC, Mochly-Rosen D. (2015) J Mol Med [PubMed]

Spatial trigger waves: positive feedback gets you a long way.

Gelens L, Anderson GA, Ferrell JE Jr. (2014) Mol Biol Cell [PubMed]

Aldehyde dehydrogenase 2 activation in heart failure restores mitochondrial function and improves ventricular function and remodelling.

Gomes KM, Campos JC, Bechara LR, Queliconi B, Lima VM, Disatnik MH, Magno P, Chen CH, Brum PC, Kowaltowski AJ, Mochly-Rosen D, Ferreira JC. (2014) Cardiovasc Res. [PubMed]

Sequential gene silencing using wavelength-selective caged morpholino oligonucleotides.

Yamazoe S, Liu Q, McQuade LE, Deiters A, Chen JK. (2014) Angew Chem Int Ed Engl. [PubMed]

Chemical biology strategies for posttranslational control of protein function.

Rakhit R, Navarro R, Wandless TJ. (2014) Chem Biol. [PubMed]

Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain.

Zambelli VO, Gross ER, Chen CH, Gutierrez VP, Cury Y, Mochly-Rosen D. (2014) Sci Transl Med. [PubMed]

Basal p21 controls population heterogeneity in cycling and quiescent cell cycle states.

Overton KW, Spencer SL, Noderer WL, Meyer T, Wang CL. (2014)  Proc Natl Acad Sci [PubMed]

Reorganization of enhancer patterns in transition from naive to primed pluripotency.

Buecker C, Srinivasan R, Wu Z, Calo E, Acampora D, Faial T, Simeone A, Tan M, Swigut T, Wysocka J. (2014) Cell Stem Cell. [PubMed]

Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability.

Sollier J, Stork CT, García-Rubio ML, Paulsen RD, Aguilera A, Cimprich KA. (2014) Mol Cell. [PubMed]

Assessing subunit dependency of the Plasmodium proteasome using small molecule inhibitors and active site probes.

Li H, van der Linden WA, Verdoes M, Florea BI, McAllister FE, Govindaswamy K, Elias JE, Bhanot P, Overkleeft HS, Bogyo M. (2014) ACS Chem Biol. [PubMed]

Role of disease-associated tolerance in infectious superspreaders.

Gopinath S, Lichtman JS, Bouley DM, Elias JE, Monack DM. (2014) Proc Natl Acad Sci USA [PubMed]

The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability.

Hamperl S, Cimprich KA. (2014) DNA Repair (Amst). [PubMed]

An evolutionarily conserved prion-like element converts wild fungi from metabolic specialists to generalists.

Jarosz DF, Lancaster AK, Brown JC, Lindquist S. (2014) Cell. [PubMed]

Cross-kingdom chemical communication drives a heritable, mutually beneficial prion-based transformation of metabolism.

Jarosz DF, Brown JC, Walker GA, Datta MS, Ung WL, Lancaster AK, Rotem A, Chang A, Newby GA, Weitz DA, Bisson LF, Lindquist S. (2014) Cell. [PubMed]

Pernicious pathogens or expedient elements of inheritance: the significance of yeast prions.

Byers JS, Jarosz DF. (2014) PLoS Pathog. [PubMed]

Dynamic recruitment of the curvature-sensitive protein ArhGAP44 to nanoscale membrane deformations limits exploratory filopodia initiation in neurons.

Galic M, Tsai FC, Collins SR, Matis M, Bandara S, Meyer T. (2014) Elife. [PubMed]

p53 suppresses muscle differentiation at the myogenin step in response to genotoxic stress.

Yang ZJ, Kenzelmann Broz D, Noderer WL, Ferreira JP, Overton KW, Spencer SL, Meyer T, Tapscott SJ, Attardi LD, Wang CL. (2014) Cell Death Differ. [PubMed]

Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability.

Sollier J, Stork CT, García-Rubio ML, Paulsen RD, Aguilera A, Cimprich KA. (2014)  Mol Cell. [PubMed]

Ultrasensitivity part II: multisite phosphorylation, stoichiometric inhibitors, and positive feedback.

Ferrell JE, Jr, Ha SH.(2014) Trends Biochem Sci. [PubMed]

Ultrasensitivity part III: cascades, bistable switches, and oscillators.

Ferrell JE Jr, Ha SH. (2014) Trends Biochem Sci. [PubMed]

Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: Benefits of Alda-1.

Gomes KM, Bechara LR, Lima VM, Ribeiro MA, Campos JC, Dourado PM, Kowaltowski AJ, Mochly-Rosen D, Ferreira JC (2014) Int J Cardiol. [PubMed]

RNA helicase DDX21 coordinates transcription and ribosomal RNA processing.

Calo E, Flynn RA, Martin L, Spitale RC, Chang HY, Wysocka J. (2014) Nature [PubMed]

The many hats of protein kinase Cδ: one enzyme with many functions.

Qvit N, Mochly-Rosen D. (2014) Biochem Soc Trans. [PubMed]

Inappropriate p53 activation during development induces features of CHARGE syndrome.

Van Nostrand JL, Brady CA, Jung H, Fuentes DR, Kozak MM, Johnson TM, Lin CY, Lin CJ, Swiderski DL, Vogel H, Bernstein JA, Attié-Bitach T, Chang CP, Wysocka J, Martin DM, Attardi LD. (2014) Nature. [PubMed]

Crowdsourced analysis of clinical trial data to predict amyotrophic lateral sclerosis progression.

Küffner R, Zach N, Norel R, Hawe J, Schoenfeld D, Wang L, Li G, Fang L, Mackey L, Hardiman O, Cudkowicz M, Sherman A, Ertaylan G, Grosse-Wentrup M, Hothorn T, van Ligtenberg J, Macke JH, Meyer T, Schölkopf B, Tran L, Vaughan R, Stolovitzky G, Leitner ML. (2014) Nat Biotechnol. [PubMed]

Spatial trigger waves: positive feedback gets you a long way.

Gelens L, Anderson GA, Ferrell JE Jr. (2014) Mol Biol Cell. [PubMed]

Role of disease-associated tolerance in infectious superspreaders.

Gopinath S, Lichtman JS, Bouley DM, Elias JE, Monack DM. (2014) Proc Natl Acad Sci USA [PubMed]

Changes in oscillatory dynamics in the cell cycle of early Xenopus laevis embryos.

Tsai TY, Theriot JA, Ferrell JE Jr. (2014) PLoS Biol. [PubMed]

A Personalized Medicine Approach for Asian-Americans with the Aldehyde Dehydrogenase 2*2 Variant.

Gross ER, Zambelli VO, Small BA, Ferreira JC, Chen CH, Mochly-Rosen D. (2014) Annu Rev Pharmacol Toxicol. [PubMed]

Chemical Biology Strategies for Posttranslational Control of Protein Function.

Rakhit R, Navarro R, Wandless TJ. (2014) Chem Biol. [PubMed]

Ultrasensitivity part I: Michaelian responses and zero-order ultrasensitivity.

Ferrell JE Jr, Ha SH. (2014) Trends Biochem Sci. [PubMed]

Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system.

Ebert AD, Kodo K, Liang P, Wu H, Huber BC, Riegler J, Churko J, Lee J, de Almeida P, Lan F, Diecke S, Burridge PW, Gold JD, Mochly-Rosen D, Wu JC. (2014) Sci Transl Med. [PubMed]

General method for regulating protein stability with light

Bonger KM, Rakhit R, Payumo AY, Chen JK, Wandless TJ. (2014)
ACS Chem Biol. [PubMed]

Cross-kingdom chemical communication drives a heritable, mutually beneficial prion-based transformation of metabolism.

Jarosz DF, Brown JC, Walker GA, Datta MS, Ung WL, Lancaster AK, Rotem A, Chang A, Newby GA, Weitz DA, Bisson LF, Lindquist S. (2014) Cell. [PubMed]

An Evolutionarily Conserved Prion-like Element Converts Wild Fungi from Metabolic Specialists to Generalists.

Jarosz DF, Lancaster AK, Brown JC, Lindquist S. (2014) Cell. [PubMed]

Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain

Zambelli VO, Gross ER, Chen CH, Gutierrez VP, Cury Y, Mochly-Rosen D.(2014) Sci Transl Med. [PubMed]

Effect of increasing dietary fiber on plasma levels of colon-derived solutes in hemodialysis patients

Zambelli VO, Gross ER, Chen CH, Gutierrez VP, Cury Y, Mochly-Rosen D. (2014) Sci Transl Med. [PubMed]

Sequential Gene Silencing Using Wavelength-Selective Caged Morpholino Oligonucleotides.

Yamazoe S, Liu Q, McQuade LE, Deiters A, Chen JK. (2014) Angew Chem Int Ed Engl.  [PubMed]

Erythematous lesions on the trunk and upper extremities.

Chen JK, Dann F.J (2014) Am Acad Dermatol. [PubMed]

Inappropriate p53 activation during development induces features of CHARGE syndrome.

Van Nostrand JL, Brady CA, Jung H, Fuentes DR, Kozak MM, Johnson TM, Lin CY, Lin CJ, Swiderski DL, Vogel H, Bernstein JA, Attié-Bitach T, Chang CP, Wysocka J, Martin DM, Attardi LD. (2014) Nature. [PubMed]

Nitroreductase-Activatable Morpholino Oligonucleotides for in Vivo Gene Silencing.

Yamazoe S, McQuade LE, Chen JK. (2014) ACS Chem Biol. [PubMed]

In vivo imaging of hedgehog pathway activation with a nuclear fluorescent reporter.

Mich JK, Payumo AY, Rack PG, Chen JK. (2014) PLoS One. [PubMed]

The challenge in translating basic research discoveries to treatment of Huntington disease.

Mochly-Rosen D, Disatnik MH, Qi X (2014) Rare Dis. [PubMed]

Arhgap36-dependent activation of Gli transcription factors.

Rack PG, Ni J, Payumo AY, Nguyen V, Crapster JA, Hovestadt V, Kool M, Jones DT, Mich JK, Firestone AJ, Pfister SM, Cho YJ,Chen JK. (2014) Proc Natl Acad Sci U S A. [PubMed]

Stromal response to Hedgehog signaling restrains pancreatic cancer progression

Lee JJ, Perera RM, Wang H, Wu DC, Liu XS, Han S, Fitamant J, Jones PD, Ghanta KS, Kawano S, Nagle JM, Deshpande V, Boucher Y, Kato T, Chen JK, Willmann JK, Bardeesy N, Beachy PA. (2014) Proc Natl Acad Sci U S A. [PubMed]

DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis.

Zeman MK, Lin JR, Freire R, Cimprich KA. (2014) J Cell Biol. [PubMed]

Direct kinetochore-spindle pole connections are not required for chromosome segregation.

Sikirzhytski V, Magidson V, Steinman JB, He J, Le Berre M, Tikhonenko I, Ault JG, McEwen BF, Chen JK, Sui H, Piel M, Kapoor TM, Khodjakov A. (2014) J Cell Biol. [PubMed}

The calcium-dependent protein kinase 3 of toxoplasma influences basal calcium levels and functions beyond egress as revealed by quantitative phosphoproteome analysis.

Treeck M, Sanders JL, Gaji RY, LaFavers KA, Child MA, Arrizabalaga G, Elias JE, Boothroyd JC. (2014) PLoS Pathog. [PubMed]

Assessing subunit dependency of the Plasmodium proteasome using small molecule inhibitors and active site probes.

Li H, van der Linden WA, Verdoes M, Florea BI, McAllister FE, Govindaswamy K, Elias JE, Bhanot P, Overkleeft HS, Bogyo M. (2014) ACS Chem Biol. [PubMed]

Pernicious pathogens or expedient elements of inheritance: the significance of yeast prions

Byers JS, Jarosz DF. (2014) PLoS Pathog. [PubMed] 

A General method for regulating protein stability with light

Bonger KM, Rakhit R, Payumo AY, Chen JK, Wandless TJ (2014) ACS Chem Biol. [PubMed}

Host-centric proteomics of stool: a novel strategy focused on intestinal responses to the gut microbiota.

Lichtman JS, Marcobal A, Sonnenburg JL, Elias JE. (2013) Mol Cell Proteomics. [PubMed]

Regulators of calcium homeostasis identified by inference of kinetic model parameters from live single cells perturbed by siRNA.

Bandara S, Malmersjö S, Meyer T. (2013) Sci. Signal. [PubMed]

Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction.

Disatnik MH, Ferreira JC, Campos JC, Gomes KS, Dourado PM, Qi X, Mochly-Rosen D. (2013) J Am Heart Assoc. [PubMed]

Human genetic variation within neural crest enhancers: molecular and phenotypic implications.

Rada-Iglesias A, Prescott SL, Wysocka J. (2013) Philos Trans R Soc Lond B Biol Sci. [PubMed]

Gli Protein Activity Is Controlled by Multisite Phosphorylation in Vertebrate Hedgehog Signaling.

Niewiadomski P, Kong JH, Ahrends R, Ma Y, Humke EW, Khan S, Teruel MN, Novitch BG, Rohatgi R. (2013) Cell Rep. [PubMed]

Feedback loops and reciprocal regulation: recurring motifs in the systems biology of the cell cycle.

Ferrell JE Jr. (2013) Curr Opin Cell Biol. 25(6):676-86 [PubMed]

General Method for Regulating Protein Stability with Light.

Bonger KM, Rakhit R, Payumo AY, Chen JK, Wandless TJ. (2013) ACS Chem Biol. [PubMed]

Selective activation of protein kinase C∊ in mitochondria is neuroprotective in vitro and reduces focal ischemic brain injury in mice.

Sun X, Budas GR, Xu L, Barreto GE, Mochly-Rosen D, Giffard RG. (2013) J Neurosci Res [PubMed]

FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.

Spiekerkoetter E, Tian X, Cai J, Hopper RK, Sudheendra D, Li CG, El-Bizri N, Sawada H, Haghighat R, Chan R, Haghighat L, de Jesus Perez V, Wang L, Reddy S, Zhao M, Bernstein D, Solow-Cordero DE, Beachy PA, Wandless TJ, Ten Dijke P, Rabinovitch M. (2013) J Clin Invest [PubMed]

The E3 Ubiquitin Ligase UBE3C Enhances Proteasome Processivity by Ubiquitinating Partially Proteolyzed Substrates.

Chu BW, Kovary KM, Guillaume J, Chen LC, Teruel MN, Wandless TJ. (2013) J Biol Chem [PubMed]

Dosage of Dyrk1a Shifts Cells within a p21-Cyclin D1 Signaling Map to Control the Decision to Enter the Cell Cycle.

Chen JY, Lin JR, Tsai FC, Meyer T. (2013) Mol Cell [PubMed]

The Proliferation-Quiescence Decision Is Controlled by a Bifurcation in CDK2 Activity at Mitotic Exit.

Spencer SL, Cappell SD, Tsai FC, Overton KW, Wang CL, Meyer T. (2013) Cell [PubMed]

The Stanford Institute for Chemical Biology.

Chen JK, Du Bois J, Glenn J, Herschlag D, Khosla C. (2013) ACS Chem Biol [PudMed]

Mitotic trigger waves and the spatial coordination of the Xenopus cell cycle

Chang JB, Ferrell JE Jr. (2013) Nature. [PubMed]

Neuropilin-2 contributes to tumorigenicity in a mouse model of Hedgehog pathway medulloblastoma.

Hayden Gephart MG, Su YS, Bandara S, Tsai FC, Hong J, Conley N, Rayburn H, Milenkovic L, Meyer T, Scott MP. (2013) J Neurooncol. [PubMed]

Nociceptive-induced myocardial remote conditioning is mediated by neuronal gamma protein kinase C.

Gross ER, Hsu AK, Urban TJ, Mochly-Rosen D, Gross GJ. (2013) Basic Res Cardiol. 108(5):381 [PubMed]

NEK8 Links the ATR-Regulated Replication Stress Response and S Phase CDK Activity to Renal Ciliopathies.

Choi HJ, Lin JR, Vannier JB, Slaats GG, Kile AC, Paulsen RD, Manning DK, Beier DR, Giles RH, Boulton SJ, Cimprich KA. (2013) Mol Cell. 51(4):423-39 [PubMed]

Rapid and Tunable Control of Protein Stability in Caenorhabditis elegans Using a Small Molecule.

Cho U, Zimmerman SM, Chen LC, Owen E, Kim JV, Kim SK, Wandless TJ. (2013) PLoS One 8(8):e72393 [PubMed]

A Novel Aldehyde Dehydrogenase-3 Activator (Alda-89) Protects Submandibular Gland Function from Irradiation without Accelerating Tumor Growth.

Xiao N, Cao H, Chen CH, Kong CS, Ali R, Chan C, Sirjani D, Graves E, Koong A, Giaccia A, Mochly-Rosen D, Le QT. (2013) Clin Cancer Res. 19(16):4455-64 [PubMed]

Emerging technologies in molecular imaging: new windows into biology.

Chen JK, Kikuchi K. (2013) Curr Opin Chem Biol. 17(4):635-6 [PubMed]

Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Phosphorylation by PKCδ Inhibits Mitochondria Elimination by Lysosomal-like Structures following Ischemia and Reoxygenation-induced Injury.

Yogalingam G, Hwang S, Ferreira JC, Mochly-Rosen D. (2013) J Biol Chem. 288(26):18947-60 [PubMed]

Inside-out connections: the ER meets the plasma membrane.

Malmersjö S, Meyer T. (2013) Cell 153(7):1423-4 [PubMed]

Visualizing cellular interactions with a generalized proximity reporter.

Sellmyer MA, Bronsart L, Imoto H, Contag CH, Wandless TJ, Prescher JA. Proc. Natl. Acad. Sci. 110(21):8567-72 [PubMed]

The Cdk1-APC/C cell cycle oscillator circuit functions as a time-delayed, ultrasensitive switch.

Yang Q, Ferrell JE Jr. (2013) Nat. Cell. Biol. 15(5):519-25 [PubMed]

A Role for the MRN Complex in ATR Activation via TOPBP1 Recruitment.

Duursma AM, Driscoll R, Elias JE, Cimprich KA. (2013) Mol. Cell. 50(1):116-22 [ScienceDirect]

A localized Wnt signal orients asymmetric stem cell division in vitro.

Habib SJ, Chen BC, Tsai FC, Anastassiadis K, Meyer T, Betzig E, Nusse R. (2013) Science. 339(6126):1445-8 [PubMed]

Modification of enhancer chromatin: what, how, and why?

Calo E, Wysocka J. (2013) Mol. Cell. 49(5):825-37 [PubMed]

Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development.

Li W, Xiong Y, Shang C, Twu KY, Hang CT, Yang J, Han P, Lin CY, Lin CJ, Tsai FC, Stankunas K, Meyer T, Bernstein D, Pan M, Chang CP. (2013) Proc. Natl. Acad. Sci. 110(5):1738-43 [PubMed]

The chromatin remodeling factor Chd1l is required in the preimplantation embryo.

Snider AC, Leong D, Wang QT, Wysocka J, Yao MW, Scott MP. (2013) Biol. Open. 2(2):121-31 [PubMed]

The genomic basis of adaptive evolution in threespine sticklebacks.

Jones FC¹, Grabherr MG, Chan YF, Russell P, Mauceli E, Johnson J, Swofford R, Pirun M, Zody MC, White S, Birney E, Searle S, Schmutz J, Grimwood J, Dickson MC, Myers RM, Miller CT, Summers BR, Knecht AK, Brady SD, Zhang H, Pollen AA, Howes T, Amemiya C; Broad Institute Genome Sequencing Platform & Whole Genome Assembly Team, Baldwin J, Bloom T, Jaffe DB, Nicol R, Wilkinson J, Lander ES, Di Palma F, Lindblad-Toh K, Kingsley DM. (2012) Nature. [PubMed]

Design of experiments to investigate dynamic cell signaling models.

Bandara S, Meyer T. (2012) Methods Mol. Biol. 880:109-18 [PubMed]

Bistability in one equation or fewer.

Anderson GA, Liu X, Ferrell JE Jr. (2012) Methods Mol Biol. 880:53-67 [PubMed]

In vivo measurement of aldehyde dehydrogenase-2 activity in rat liver ethanol model using dynamic MRSI of hyperpolarized [1-(13) C]pyruvate.

Josan S, Xu T, Yen YF, Hurd R, Ferreira J, Chen CH, Mochly-Rosen D, Pfefferbaum A, Mayer D, Spielman D. (2012) NMR Biomed. [PubMed]

Protein kinase C, an elusive therapeutic target?

Mochly-Rosen D, Das K, Grimes KV. (2012) Nat. Rev. Drug Discov. 11(12):937-57 [PubMed]

Coordinated oscillations in cortical actin and Ca2+ correlate with cycles of vesicle secretion.

Wollman R, Meyer T. (2012) Nat. Cell Biol. 14(12):1261-9 [PubMed]

Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest.

Rada-Iglesias A, Bajpai R, Prescott S, Brugmann SA, Swigut T, Wysocka J. (2012) Cell Stem Cell 11(5):633-48 [PubMed]

Consecutive positive feedback loops create a bistable switch that controls preadipocyte-to-adipocyte conversion.

Park BO, Ahrends R, Teruel MN. (2012) Cell Rep 2(4):976-90 [PubMed]

Intracellular context affects levels of a chemically dependent destabilizing domain.

Sellmyer MA, Chen LC, Egeler EL, Rakhit R, Wandless TJ. (2012) PLoS ONE 7(9):e43297 [PubMed]

External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane.

Galic M, Jeong S, Tsai FC, Joubert LM, Wu YI, Hahn KM, Cui Y, Meyer T. (2012) Nat. Cell Biol. 14(8):874-81 [PubMed]

Differential trafficking of transport vesicles contributes to the localization of dendritic proteins.

Al-Bassam S, Xu M, Wandless TJ, Arnold DB. (2012) Cell Rep. 2(1):89-100 [PubMed]

Cyclic caged morpholinos: conformationally gated probes of embryonic gene function.

Yamazoe S, Shestopalov IA, Provost E, Leach SD, Chen JK. (2012) Angew. Chem. Int. Ed. Engl. 51(28):6908-11 [PubMed]

Mitigation of radiation-induced dermatitis by activation of aldehyde dehydrogenase 2 using topical alda-1 in mice.

Ning S, Budas GR, Churchill EN, Chen CH, Knox SJ, Mochly-Rosen D. (2012) Radiat. Res. 178(1):69-74 [PubMed]

Spatial positive feedback at the onset of mitosis.

Santos SD, Wollman R, Meyer T, Ferrell JE. (2012) Cell 149(7):1500-13 [PubMed]

Bistability, bifurcations, and Waddington’s epigenetic landscape.

Ferrell JE. (2012) Curr. Biol. 22(11):R458-66 [PubMed]

Enhancers as information integration hubs in development: lessons from genomics.

Buecker C, Wysocka J. (2012) Trends Genet. 28(6):276-84 [PubMed]

Ca2+ pulses control local cycles of lamellipodia retraction and adhesion along the front of migrating cells.

Tsai FC, Meyer T. (2012) Curr. Biol. 22(9):837-42 [PubMed]

Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein.

Firestone AJ, Weinger JS, Maldonado M, Barlan K, Langston LD, O’Donnell M, Gelfand VI, Kapoor TM, Chen JK. (2012) Nature 484(7392):125-9 [PubMed]

The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome.

Kuo AJ, Song J, Cheung P, Ishibe-Murakami S, Yamazoe S, Chen JK, Patel DJ, Gozani O. (2012) Nature 484(7392):115-9 [PubMed]

Protein quality control disruption by PKCβII in heart failure; rescue by the selective PKCβII inhibitor, βIIV5-3.

Ferreira JC, Boer BN, Grinberg M, Brum PC, Mochly-Rosen D. (2012) PLoS ONE 7(3):e33175 [PubMed]

Identification of εPKC targets during cardiac ischemic injury.

Budas G, Costa HM, Ferreira JC, Teixeira da Silva Ferreira A, Perales J, Krieger JE, Mochly-Rosen D, Schechtman D. (2012) Circ. J. 76(6):1476-85 [PubMed]

Destabilizing domains derived from the human estrogen receptor.

Miyazaki Y, Imoto H, Chen LC, Wandless TJ. (2012) J. Am. Chem. Soc. 134(9):3942-5 [PubMed]

Spatiotemporal resolution of the Ntla transcriptome in axial mesoderm development.

Shestopalov IA, Pitt CL, Chen JK. (2012) Nat. Chem. Biol. 8(3):270-6 [PubMed]

A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision.

Chen JY, Lin JR, Cimprich KA, Meyer T. (2012) Mol. Cell 45(2):196-209 [PubMed]

Imaging the impact of chemically inducible proteins on cellular dynamics in vivo.

Leong HS, Lizardo MM, Ablack A, McPherson VA, Wandless TJ, Chambers AF, Lewis JD. (2012) PLoS ONE 7(1):e30177 [PubMed]

Regulation of cardiac excitability by protein kinase C isozymes.

Ferreira JC, Mochly-Rosen D, Boutjdir M. (2012) Front Biosci (Schol Ed) 4:532-46 [PubMed]

Nitroglycerin use in myocardial infarction patients.

Ferreira JC, Mochly-Rosen D. (2012) Circ. J. 76(1):15-21 [PubMed]

A novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichment in vivo.

Banh A, Xiao N, Cao H, Chen CH, Kuo P, Krakow T, Bavan B, Khong B, Yao M, Ha C, Kaplan MJ, Sirjani D, Jensen K, Kong CS, Mochly-Rosen D, Koong AC, Le QT. (2011) Clin. Cancer Res. 17(23):7265-72 [PubMed]

Pharmacological inhibition of βIIPKC is cardioprotective in late-stage hypertrophy.

Ferreira JC, Koyanagi T, Palaniyandi SS, Fajardo G, Churchill EN, Budas G, Disatnik MH, Bernstein D, Brum PC, Mochly-Rosen D. (2011) J. Mol. Cell. Cardiol. 51(6):980-7 [PubMed]

Hedgehog and retinoic acid signaling cooperate to promote motoneurogenesis in zebrafish.

Mich JK, Chen JK. (2011) Development 138(23):5113-9 [PubMed]

Neuropilins are positive regulators of Hedgehog signal transduction.

Hillman RT, Feng BY, Ni J, Woo WM, Milenkovic L, Hayden Gephart MG, Teruel MN, Oro AE, Chen JK, Scott MP. (2011) Genes Dev. 25(22):2333-46 [PubMed]

A mechanism for the evolution of phosphorylation sites.

Pearlman SM, Serber Z, Ferrell JE. (2011) Cell 147(4):934-46 [PubMed]

Salmonella exploits Arl8B-directed kinesin activity to promote endosome tubulation and cell-to-cell transfer.

Kaniuk NA, Canadien V, Bagshaw RD, Bakowski M, Braun V, Landekic M, Mitra S, Huang J, Heo WD, Meyer T, Pelletier L, Andrews-Polymenis H, McClelland M, Pawson T, Grinstein S, Brumell JH. (2011) Cell. Microbiol. 13(11):1812-23 [PubMed]

β2-adrenergic receptors mediate cardioprotection through crosstalk with mitochondrial cell death pathways.

Fajardo G, Zhao M, Berry G, Wong LJ, Mochly-Rosen D, Bernstein D. (2011) J. Mol. Cell. Cardiol. 51(5):781-9 [PubMed]

The phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii reveal unusual adaptations within and beyond the parasites’ boundaries.

Treeck M, Sanders JL, Elias JE, Boothroyd JC. (2011) Cell Host Microbe. 10(4):410-9 [PubMed]

A crucial requirement for Hedgehog signaling in small cell lung cancer.

Park KS, Martelotto LG, Peifer M, Sos ML, Karnezis AN, Mahjoub MR, Bernard K, Conklin JF, Szczepny A, Yuan J, Guo R, Ospina B, Falzon J, Bennett S, Brown TJ, Markovic A, Devereux WL, Ocasio CA, Chen JK, Stearns T, Thomas RK, Dorsch M, Buonamici S, Watkins DN, Peacock CD, Sage J. (2011) Nat. Med. 17(11):1504-8 [PubMed]

βIIPKC and εPKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failure.

Ferreira JC, Brum PC, Mochly-Rosen D. (2011) J. Mol. Cell. Cardiol. 51(4):479-84 [PubMed]

Spatiotemporal control of embryonic gene expression using caged morpholinos.

Shestopalov IA, Chen JK. (2011) Methods Cell Biol. 104:151-72 [PubMed]

Parallel adaptive feedback enhances reliability of the Ca2+ signaling system.

Abell E, Ahrends R, Bandara S, Park BO, Teruel MN. (2011) Proc. Natl. Acad. Sci. U.S.A. 108(35):14485-90 [PubMed]

PKCβII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses.

Palaniyandi SS, Ferreira JC, Brum PC, Mochly-Rosen D. (2011) J. Cell. Mol. Med. 15(8):1769-77 [PubMed]

Chemical ‘Jekyll and Hyde’s: small-molecule inhibitors of developmental signaling pathways.

Sakata T, Chen JK. (2011) Chem Soc Rev 40(8):4318-31 [PubMed]

Small-molecule displacement of a cryptic degron causes conditional protein degradation.

Bonger KM, Chen LC, Liu CW, Wandless TJ. (2011) Nat. Chem. Biol. 7(8):531-7 [PubMed]

PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cells.

Kim J, Koyanagi T, Mochly-Rosen D. (2011) Prostate 71(9):946-54 [PubMed]

STIM proteins and the endoplasmic reticulum-plasma membrane junctions.

Carrasco S, Meyer T. (2011) Annu. Rev. Biochem. 80:973-1000 [PubMed]

Therapeutic potential for protein kinase C inhibitor in vascular restenosis.

Ding RQ, Tsao J, Chai H, Mochly-Rosen D, Zhou W. (2011) J. Cardiovasc. Pharmacol. Ther. 16(2):160-7 [PubMed]

SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis.

Lin JR, Zeman MK, Chen JY, Yee MC, Cimprich KA. (2011) Mol. Cell 42(2):237-49 [PubMed]

The dynamic state of protein turnover: It’s about time.

Hinkson IV, Elias JE. (2011) Trends Cell Biol. 21(5):293-303 [PubMed]

Evolutionary origins of STIM1 and STIM2 within ancient Ca2+ signaling systems.

Collins SR, Meyer T. (2011) Trends Cell Biol. 21(4):202-11 [PubMed]

Matrix metalloproteinases modulated by protein kinase Cε mediate resistin-induced migration of human coronary artery smooth muscle cells.

Ding Q, Chai H, Mahmood N, Tsao J, Mochly-Rosen D, Zhou W. (2011) J. Vasc. Surg. 53(4):1044-51 [PubMed]

Chemical control of FGF-2 release for promoting calvarial healing with adipose stem cells.

Kwan MD, Sellmyer MA, Quarto N, Ho AM, Wandless TJ, Longaker MT. (2011) J. Biol. Chem. 286(13):11307-13 [PubMed]

Modeling the cell cycle: why do certain circuits oscillate?

Ferrell JE, Tsai TY, Yang Q. (2011) Cell 144(6):874-85 [PubMed]

A unique chromatin signature uncovers early developmental enhancers in humans.

Rada-Iglesias A, Bajpai R, Swigut T, Brugmann SA, Flynn RA, Wysocka J. (2011) Nature 470(7333):279-83 [PubMed]

Ultrasensitivity in the Regulation of Cdc25C by Cdk1.

Trunnell NB, Poon AC, Kim SY, Ferrell JE. (2011) Mol. Cell 41(3):263-74 [PubMed]

Sequence-specific regulator Prdm14 safeguards mouse ESCs from entering extraembryonic endoderm fates.

Ma Z, Swigut T, Valouev A, Rada-Iglesias A, Wysocka J. (2011) Nat. Struct. Mol. Biol. 18(2):120-7 [PubMed]

Sustained inhibition of PKCα reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model.

Kim J, Thorne SH, Sun L, Huang B, Mochly-Rosen D. (2011) Oncogene 30(3):323-33 [PubMed]

Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo.

Qi X, Disatnik MH, Shen N, Sobel RA, Mochly-Rosen D. (2011) Mol. Biol. Cell 22(2):256-65 [PubMed]

Focus on: The cardiovascular system: what did we learn from the French (Paradox)?

Mochly-Rosen D, Zakhari S. (2010) Alcohol Res Health. [PubMed]

A tissue-specific atlas of mouse protein phosphorylation and expression.

Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villén J, Haas W, Sowa ME, Gygi SP. (2010) Cell 143(7):1174-89 [PubMed]

Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart Failure.

Qvit N, Mochly-Rosen D. (2010) Drug Discov Today Dis Mech 7(2):e87-e93 [PubMed]

Mitochondrial aldehyde dehydrogenase and cardiac diseases.

Chen CH, Sun L, Mochly-Rosen D. (2010) Cardiovasc. Res. 88(1):51-7 [PubMed]

Mitochondrial import of PKCε is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury.

Budas GR, Churchill EN, Disatnik MH, Sun L, Mochly-Rosen D. (2010) Cardiovasc. Res. 88(1):83-92 [PubMed]

A general chemical method to regulate protein stability in the mammalian central nervous system.

Iwamoto M, Björklund T, Lundberg C, Kirik D, Wandless TJ. (2010) Chem. Biol. 17(9):981-8 [PubMed]

The roles of cyclin A2, B1, and B2 in early and late mitotic events.

Gong D, Ferrell JE. (2010) Mol. Biol. Cell 21(18):3149-61 [PubMed]

Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting.

Deuse T, Koyanagi T, Erben RG, Hua X, Velden J, Ikeno F, Reichenspurner H, Robbins RC, Mochly-Rosen D, Schrepfer S. (2010) Circulation 122(11 Suppl):S170-8 [PubMed]

Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells.

Koda K, Salazar-Rodriguez M, Corti F, Chan NY, Estephan R, Silver RB, Mochly-Rosen D, Levi R. (2010) Circulation 122(8):771-81 [PubMed]

The NADPH oxidases NOX4 and DUOX2 regulate cell cycle entry via a p53-dependent pathway.

Salmeen A, Park BO, Meyer T. (2010) Oncogene 29(31):4473-84 [PubMed]

Synthetic strategies for studying embryonic development.

Ouyang X, Chen JK. (2010) Chem. Biol. 17(6):590-606 [PubMed]

Flipping MLL1’s switch one proline at a time.

Grow EJ, Wysocka J. (2010) Cell 141(7):1108-10 [PubMed]

Checkpoint recovery after DNA damage: a rolling stop for CDKs.

Duursma AM, Cimprich KA. (2010) EMBO Rep. 11(6):411-2 [PubMed]

Non-volume-loaded heart provides a more relevant heterotopic transplantation model.

Tang-Quan KR, Bartos J, Deuse T, Churchill E, Schäfer H, Reichenspurner H, Mochly-Rosen D, Robbins RC, Schrepfer S. (2010) Transpl. Immunol. 23(1-2):65-70 [PubMed]

Dicistronic regulation of fluorescent proteins in the budding yeast Saccharomyces cerevisiae.

Edwards SR, Wandless TJ. (2010) Yeast 27(4):229-36 [PubMed]

Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCε) knockout mice.

Budas GR, Disatnik MH, Chen CH, Mochly-Rosen D. (2010) J. Mol. Cell. Cardiol. 48(4):757-64 [PubMed]

δPKC inhibition or εPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification.

Monti M, Donnini S, Giachetti A, Mochly-Rosen D, Ziche M. (2010) J. Mol. Cell. Cardiol. 48(4):746-56 [PubMed]

Oligonucleotide-based tools for studying zebrafish development.

Shestopalov IA, Chen JK. (2010) Zebrafish 7(1):31-40 [PubMed]

CHD7 cooperates with PBAF to control multipotent neural crest formation.

Bajpai R, Chen DA, Rada-Iglesias A, Zhang J, Xiong Y, Helms J, Chang CP, Zhao Y, Swigut T, Wysocka J. (2010) Nature 463(7283):958-62 [PubMed]

Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant.

Perez-Miller S, Younus H, Vanam R, Chen CH, Mochly-Rosen D, Hurley TD. (2010) Nat. Struct. Mol. Biol. 17(2):159-64 [PubMed]

Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen.

Bienvenu F, Jirawatnotai S, Elias JE, Meyer CA, Mizeracka K, Marson A, Frampton GM, Cole MF, Odom DT, Odajima J, Geng Y, Zagozdzon A, Jecrois M, Young RA, Liu XS, Cepko CL, Gygi SP, Sicinski P. (2010) Nature 463(7279):374-8 [PubMed]

Controlling destiny through chemistry: small-molecule regulators of cell fate.

Firestone AJ, Chen JK. (2010) ACS Chem. Biol. 5(1):15-34 [PubMed]

Ischaemic preconditioning improves proteasomal activity and increases the degradation of δPKC during reperfusion.

Churchill EN, Ferreira JC, Brum PC, Szweda LI, Mochly-Rosen D. (2010) Cardiovasc. Res. 85(2):385-94 [PubMed]

Regulation of mitochondrial processes: a target for heart failure.

Palaniyandi SS, Qi X, Yogalingam G, Ferreira JC, Mochly-Rosen D. (2010) Drug Discov Today Dis Mech 7(2):e95-e102 [PubMed]

MS/MS/MS reveals false positive identification of histone serine methylation.

Zhang J, Chen Y, Zhang Z, Xing G, Wysocka J, Zhao Y. (2010) J. Proteome Res. 9(1):585-94 [PubMed]

Systems biologists seek fuller integration of systems biology approaches in new cancer research programs.

Wolkenhauer O, Auffray C, Baltrusch S, Blüthgen N, Byrne H, Cascante M, Ciliberto A, Dale T, Drasdo D, Fell D, Ferrell JE, Gallahan D, Gatenby R, Günther U, Harms BD, Herzel H, Junghanss C, Kunz M, van Leeuwen I, Lenormand P, Levi F, Linnebacher M, Lowengrub J, Maini PK, Malik A, Rateitschak K, Sansom O, Schäfer R, Schürrle K, Sers C, Schnell S, Shibata D, Tyson J, Vera J, White M, Zhivotovsky B, Jaster R. (2010) Cancer Res. 70(1):12-3 [PubMed]

Target-decoy search strategy for mass spectrometry-based proteomics.

Elias JE, Gygi SP. (2010) Methods Mol. Biol. 604:55-71 [PubMed]

Identification of beta-secretase (BACE1) substrates using quantitative proteomics.

Hemming ML, Elias JE, Gygi SP, Selkoe DJ. (2009) PLoS ONE 4(12):e8477 [PubMed]

Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells.

Peng JC, Valouev A, Swigut T, Zhang J, Zhao Y, Sidow A, Wysocka J. (2009) Cell 139(7):1290-302 [PubMed]

Simple, realistic models of complex biological processes: positive feedback and bistability in a cell fate switch and a cell cycle oscillator.

Ferrell JE, Pomerening JR, Kim SY, Trunnell NB, Xiong W, Huang CY, Machleder EM. (2009) FEBS Lett. 583(24):3999-4005 [PubMed]

Signaling motifs and Weber’s law.

Ferrell JE. (2009) Mol. Cell 36(5):724-7 [PubMed]

Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA.

Hendrickson DG, Hogan DJ, McCullough HL, Myers JW, Herschlag D, Ferrell JE, Brown PO. (2009) PLoS Biol. 7(11):e1000238 [PubMed]

Optimal experimental design for parameter estimation of a cell signaling model.

Bandara S, Schlöder JP, Eils R, Bock HG, Meyer T. (2009) PLoS Comput. Biol. 5(11):e1000558 [PubMed]

HARPing on about the DNA damage response during replication.

Driscoll R, Cimprich KA. (2009) Genes Dev. 23(20):2359-65 [PubMed]

Versatile synthesis and rational design of caged morpholinos.

Ouyang X, Shestopalov IA, Sinha S, Zheng G, Pitt CL, Li WH, Olson AJ, Chen JK. (2009) J. Am. Chem. Soc. 131(37):13255-69 [PubMed]

Regulated RalBP1 binding to RalA and PSD-95 controls AMPA receptor endocytosis and LTD.

Han K, Kim MH, Seeburg D, Seo J, Verpelli C, Han S, Chung HS, Ko J, Lee HW, Kim K, Heo WD, Meyer T, Kim H, Sala C, Choi SY, Sheng M, Kim E. (2009) PLoS Biol. 7(9):e1000187 [PubMed]

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.

Hyman JM, Firestone AJ, Heine VM, Zhao Y, Ocasio CA, Han K, Sun M, Rack PG, Sinha S, Wu JJ, Solow-Cordero DE, Jiang J, Rowitch DH, Chen JK. (2009) Proc. Natl. Acad. Sci. U.S.A. 106(33):14132-7 [PubMed]

A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability.

Paulsen RD, Soni DV, Wollman R, Hahn AT, Yee MC, Guan A, Hesley JA, Miller SC, Cromwell EF, Solow-Cordero DE, Meyer T, Cimprich KA. (2009) Mol. Cell 35(2):228-39 [PubMed]

Converse conformational control of smoothened activity by structurally related small molecules.

Yang H, Xiang J, Wang N, Zhao Y, Hyman J, Li S, Jiang J, Chen JK, Yang Z, Lin S. (2009) J. Biol. Chem. 284(31):20876-84 [PubMed]

Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target?

Budas GR, Disatnik MH, Mochly-Rosen D. (2009) Trends Cardiovasc. Med. 19(5):158-64 [PubMed]

Proliferating cell nuclear antigen uses two distinct modes to move along DNA.

Kochaniak AB, Habuchi S, Loparo JJ, Chang DJ, Cimprich KA, Walter JC, van Oijen AM. (2009) J. Biol. Chem. 284(26):17700-10 [PubMed]

Q&A: Cooperativity.

Ferrell JE. (2009) J. Biol. 8(6):53 [PubMed]

Protein kinase C in heart failure: a therapeutic target?

Palaniyandi SS, Sun L, Ferreira JC, Mochly-Rosen D. (2009) Cardiovasc. Res. 82(2):229-39 [PubMed]

Tuning the activation threshold of a kinase network by nested feedback loops.

Justman QA, Serber Z, Ferrell JE, El-Samad H, Shokat KM. (2009) Science 324(5926):509-12 [PubMed]

Fallen immortals.

Swigut T, Wysocka J. (2009) Cell 137(2):203-5 [PubMed]

Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent.

Mich JK, Blaser H, Thomas NA, Firestone AJ, Yelon D, Raz E, Chen JK. (2009) Dev. Biol. 328(2):342-54 [PubMed]

Preserved coronary endothelial function by inhibition of delta protein kinase C in a porcine acute myocardial infarction model.

Kaneda H, Ikeno F, Inagaki K, Mochly-Rosen D. (2009) Int. J. Cardiol. 133(2):256-9 [PubMed]

Quantitative analysis of cell cycle phase durations and PC12 differentiation using fluorescent biosensors.

Hahn AT, Jones JT, Meyer T. (2009) Cell Cycle 8(7):1044-52 [PubMed]

Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells.

Lim DA, Huang YC, Swigut T, Mirick AL, Garcia-Verdugo JM, Wysocka J, Ernst P, Alvarez-Buylla A. (2009) Nature 458(7237):529-33 [PubMed]

A small molecule that binds Hedgehog and blocks its signaling in human cells.

Stanton BZ, Peng LF, Maloof N, Nakai K, Wang X, Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A, Schreiber SL. (2009) Nat. Chem. Biol. 5(3):154-6 [PubMed]

Regulating protein stability in mammalian cells using small molecules.

Hagan EL, Banaszynski LA, Chen LC, Maynard-Smith LA, Wandless TJ. (2009) Cold Spring Harb Protoc 2009(3):pdb.prot5172 [PubMed]

A general method for conditional regulation of protein stability in living animals.

Sellmyer MA, Thorne SH, Banaszynski LA, Contag CH, Wandless TJ. (2009) Cold Spring Harb Protoc 2009(3):pdb.prot5173 [PubMed]

The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling.

Cupido T, Rack PG, Firestone AJ, Hyman JM, Han K, Sinha S, Ocasio CA, Chen JK. (2009) Angew. Chem. Int. Ed. Engl. 48(13):2321-4 [PubMed]

Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of εPKC and activation of aldehyde dehydrogenase 2.

Churchill EN, Disatnik MH, Mochly-Rosen D. (2009) J. Mol. Cell. Cardiol. 46(2):278-84 [PubMed]

DNA damage tolerance: when it’s OK to make mistakes.

Chang DJ, Cimprich KA. (2009) Nat. Chem. Biol. 5(2):82-90 [PubMed]

Calcium flickers lighting the way in chemotaxis?

Collins SR, Meyer T. (2009) Dev. Cell 16(2):160-1 [PubMed]

Activating δPKC antagonizes the protective effect of ERK1/2 inhibition against stroke in rats.

Castañeda D, Zhao H, Mochly-Rosen D, Steinberg GK. (2009) Brain Res. 1251:256-61 [PubMed]

Q&A: systems biology.

Ferrell JE. (2009) J. Biol. 8(1):2 [PubMed]

A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.

Rahdar M, Inoue T, Meyer T, Zhang J, Vazquez F, Devreotes PN. (2009) Proc. Natl. Acad. Sci. U.S.A. 106(2):480-5 [PubMed]

[Cytometric evaluation of immaturity granulocytes in infections].

Ratomski K, Zak J, Kasprzycka E, Hryniewicz K, Wysocka J. (2009) Pol. Merkur. Lekarski 26(151):14-8 [PubMed]

Rationally designed peptide regulators of protein kinase C.

Churchill EN, Qvit N, Mochly-Rosen D. (2009) Trends Endocrinol. Metab. 20(1):25-33 [PubMed]

The proteasome makes sense of mixed signals.

Wandless TJ. (2009) Nat. Chem. Biol. 5(1):3-4 [PubMed]

Mast cells and εPKC: a role in cardiac remodeling in hypertension-induced heart failure.

Palaniyandi SS, Inagaki K, Mochly-Rosen D. (2008) J. Mol. Cell. Cardiol. 45(6):779-86 [PubMed]

Modular control of endothelial sheet migration.

Vitorino P, Meyer T. (2008) Genes Dev. 22(23):3268-81 [PubMed]

Ethanol for cardiac ischemia: the role of protein kinase c.

Churchill EN, Disatnik MH, Budas GR, Mochly-Rosen D. (2008) Ther Adv Cardiovasc Dis 2(6):469-83 [PubMed]

Recent progress with FKBP-derived destabilizing domains.

Chu BW, Banaszynski LA, Chen LC, Wandless TJ. (2008) Bioorg. Med. Chem. Lett. 18(22):5941-4 [PubMed]

The impact of peptide abundance and dynamic range on stable-isotope-based quantitative proteomic analyses.

Bakalarski CE, Elias JE, Villén J, Haas W, Gerber SA, Everley PA, Gygi SP. (2008) J. Proteome Res. 7(11):4756-65 [PubMed]

Targeted and Conditional Gene Expression Workshop, 8th International Conference on Zebrafish Development and Genetics.

Chen JK, Hurlstone AF. (2008) Zebrafish 5(3):193-195 [PubMed]

Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements.

Hemming ML, Elias JE, Gygi SP, Selkoe DJ. (2008) PLoS Biol. 6(10):e257 [PubMed]

Feedback loops shape cellular signals in space and time.

Brandman O, Meyer T. (2008) Science 322(5900):390-5 [PubMed]

Chemical control of protein stability and function in living mice.

Banaszynski LA, Sellmyer MA, Contag CH, Wandless TJ, Thorne SH. (2008) Nat. Med. 14(10):1123-7 [PubMed]

Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart.

Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D. (2008) Science 321(5895):1493-5 [PubMed]

The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning.

Low WC, Wang C, Pan Y, Huang XY, Chen JK, Wang B. (2008) Dev. Biol. 321(1):188-96 [PubMed]

Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration.

Inoue T, Meyer T. (2008) PLoS ONE 3(8):e3068 [PubMed]

εPKC confers acute tolerance to cerebral ischemic reperfusion injury.

Bright R, Sun GH, Yenari MA, Steinberg GK, Mochly-Rosen D. (2008) Neurosci. Lett. 441(1):120-4 [PubMed]

Centrosomal PKCβII and pericentrin are critical for human prostate cancer growth and angiogenesis.

Kim J, Choi YL, Vallentin A, Hunrichs BS, Hellerstein MK, Peehl DM, Mochly-Rosen D. (2008) Cancer Res. 68(16):6831-9 [PubMed]

ATR: an essential regulator of genome integrity.

Cimprich KA, Cortez D. (2008) Nat. Rev. Mol. Cell Biol. 9(8):616-27 [PubMed]

Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF.

Pomerening JR, Ubersax JA, Ferrell JE. (2008) Mol. Biol. Cell 19(8):3426-41 [PubMed]

Systems biology: On the cell cycle and its switches.

Santos SD, Ferrell JE. (2008) Nature 454(7202):288-9 [PubMed]

A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size.

Kaplan DD, Zimmermann G, Suyama K, Meyer T, Scott MP. (2008) Genes Dev. 22(14):1877-93 [PubMed]

Robust, tunable biological oscillations from interlinked positive and negative feedback loops.

Tsai TY, Choi YS, Ma W, Pomerening JR, Tang C, Ferrell JE. (2008) Science 321(5885):126-9 [PubMed]

Fish ‘n clicks.

Chen JK. (2008) Nat. Chem. Biol. 4(7):391-2 [PubMed]

Alteration of gene expression during progression of hypertension-induced cardiac dysfunction in rats.

Koyanagi T, Wong LY, Inagaki K, Petrauskene OV, Mochly-Rosen D. (2008) Am. J. Physiol. Heart Circ. Physiol. 295(1):H220-6 [PubMed]

Chemical technologies for probing embryonic development.

Shestopalov IA, Chen JK. (2008) Chem Soc Rev 37(7):1294-307 [PubMed]

Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane.

Chae YC, Kim JH, Kim KL, Kim HW, Lee HY, Heo WD, Meyer T, Suh PG, Ryu SH. (2008) Mol. Biol. Cell 19(7):3111-23 [PubMed]

Pharmacological inhibition of epsilon-protein kinase C attenuates cardiac fibrosis and dysfunction in hypertension-induced heart failure.

Inagaki K, Koyanagi T, Berry NC, Sun L, Mochly-Rosen D. (2008) Hypertension 51(6):1565-9 [PubMed]

Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging.

Park WS, Heo WD, Whalen JH, O’Rourke NA, Bryan HM, Meyer T, Teruel MN. (2008) Mol. Cell 30(3):381-92 [PubMed]

Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance.

Hendrickson DG, Hogan DJ, Herschlag D, Ferrell JE, Brown PO. (2008) PLoS ONE 3(5):e2126 [PubMed]

It takes a PHD to SUMO.

Peng J, Wysocka J. (2008) Trends Biochem. Sci. 33(5):191-4 [PubMed]

Dissecting the role of PtdIns(4,5)P2 in endocytosis and recycling of the transferrin receptor.

Abe N, Inoue T, Galvez T, Klein L, Meyer T. (2008) J. Cell. Sci. 121(Pt 9):1488-94 [PubMed]

A role for GPRx, a novel GPR3/6/12-related G-protein coupled receptor, in the maintenance of meiotic arrest in Xenopus laevis oocytes.

Ríos-Cardona D, Ricardo-González RR, Chawla A, Ferrell JE. (2008) Dev. Biol. 317(1):380-8 [PubMed]

Suspended-drop electroporation for high-throughput delivery of biomolecules into cells.

Guignet EG, Meyer T. (2008) Nat. Methods 5(5):393-5 [PubMed]

Gene regulation technologies in zebrafish.

Esengil H, Chen JK. (2008) Mol Biosyst 4(4):300-8 [PubMed]

Dopamine and ethanol cause translocation of εPKC associated with εRACK: cross-talk between cAMP-dependent protein kinase A and protein kinase C signaling pathways.

Yao L, Fan P, Jiang Z, Gordon A, Mochly-Rosen D, Diamond I. (2008) Mol. Pharmacol. 73(4):1105-12 [PubMed]

Feedback regulation of opposing enzymes generates robust, all-or-none bistable responses.

Ferrell JE. (2008) Curr. Biol. 18(6):R244-5 [PubMed]

The PKCδ -Abl complex communicates ER stress to the mitochondria – an essential step in subsequent apoptosis.

Qi X, Mochly-Rosen D. (2008) J. Cell. Sci. 121(Pt 6):804-13 [PubMed]

Islet cell survival during isolation improved through protein kinase C epsilon activation.

Kvezereli M, Vallentin A, Mochly-Rosen D, Busque S, Fontaine MJ. (2008) Transplant. Proc. 40(2):375-8 [PubMed]

Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction.

Bates E, Bode C, Costa M, Gibson CM, Granger C, Green C, Grimes K, Harrington R, Huber K, Kleiman N, Mochly-Rosen D, Roe M, Sadowski Z, Solomon S, Widimsky P. (2008) Circulation 117(7):886-96 [PubMed]

Synthesis and analysis of stabilizing ligands for FKBP-derived destabilizing domains.

Grimley JS, Chen DA, Banaszynski LA, Wandless TJ. (2008) Bioorg. Med. Chem. Lett. 18(2):759-61 [PubMed]

Robust neuronal symmetry breaking by Ras-triggered local positive feedback.

Fivaz M, Bandara S, Inoue T, Meyer T. (2008) Curr. Biol. 18(1):44-50 [PubMed]

Sustained pharmacological inhibition of δPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats.

Qi X, Inagaki K, Sobel RA, Mochly-Rosen D. (2008) J. Clin. Invest. 118(1):173-82 [PubMed]

PKC isozymes in chronic cardiac disease: possible therapeutic targets?

Churchill E, Budas G, Vallentin A, Koyanagi T, Mochly-Rosen D. (2008) Annu. Rev. Pharmacol. Toxicol. 48:569-99 [PubMed]

STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels.

Brandman O, Liou J, Park WS, Meyer T. (2007) Cell 131(7):1327-39 [PubMed]

Induced fit and wit: celebrating the life of Daniel E. Koshland, Jr. (1920 – 2007).

Newton AC, Mochly-Rosen D. (2007) IUBMB Life 59(12):741-3 [PubMed]

Rapid control of protein level in the apicomplexan Toxoplasma gondii.

Herm-Götz A, Agop-Nersesian C, Münter S, Grimley JS, Wandless TJ, Frischknecht F, Meissner M. (2007) Nat. Methods 4(12):1003-5 [PubMed]

Epigenetic regulation of histone H3 serine 10 phosphorylation status by HCF-1 proteins in C. elegans and mammalian cells.

Lee S, Horn V, Julien E, Liu Y, Wysocka J, Bowerman B, Hengartner MO, Herr W. (2007) PLoS ONE 2(11):e1213 [PubMed]

Systems biology. A clock with a flip switch.

Poon AC, Ferrell JE. (2007) Science 318(5851):757-8 [PubMed]

The roles of PKC delta and epsilon isoenzymes in the regulation of myocardial ischaemia/reperfusion injury.

Churchill EN, Mochly-Rosen D. (2007) Biochem. Soc. Trans. 35(Pt 5):1040-2 [PubMed]

Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: a personal account and progress report on transferring academic discoveries to the clinic.

Budas GR, Koyanagi T, Churchill EN, Mochly-Rosen D. (2007) Biochem. Soc. Trans. 35(Pt 5):1021-6 [PubMed]

Mitochondrial protein kinase Cε (PKCε): emerging role in cardiac protection from ischaemic damage.

Budas GR, Mochly-Rosen D. (2007) Biochem. Soc. Trans. 35(Pt 5):1052-4 [PubMed]

H3K27 demethylases, at long last.

Swigut T, Wysocka J. (2007) Cell 131(1):29-32 [PubMed]

Probing ATR activation with model DNA templates.

Cimprich KA. (2007) Cell Cycle 6(19):2348-54 [PubMed]

Assessing enzyme activities using stable isotope labeling and mass spectrometry.

Everley PA, Gartner CA, Haas W, Saghatelian A, Elias JE, Cravatt BF, Zetter BR, Gygi SP. (2007) Mol. Cell Proteomics 6(10):1771-7 [PubMed]

δPKC participates in the endoplasmic reticulum stress-induced response in cultured cardiac myocytes and ischemic heart.

Qi X, Vallentin A, Churchill E, Mochly-Rosen D. (2007) J. Mol. Cell. Cardiol. 43(4):420-8 [PubMed]

Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model.

Koyanagi T, Noguchi K, Ootani A, Inagaki K, Robbins RC, Mochly-Rosen D. (2007) J. Mol. Cell. Cardiol. 43(4):517-22 [PubMed]

Light-controlled gene silencing in zebrafish embryos.

Shestopalov IA, Sinha S, Chen JK. (2007) Nat. Chem. Biol. 3(10):650-1 [PubMed]

The enantioselective synthesis of phomopsin B.

Grimley JS, Sawayama AM, Tanaka H, Stohlmeyer MM, Woiwode TF, Wandless TJ. (2007) Angew. Chem. Int. Ed. Engl. 46(43):8157-9 [PubMed]

A transgenic mouse model for high content, cell cycle phenotype screening in live primary cells.

Burney RO, Lee AI, Leong DE, Jones JT, Hahn AT, Meyer T, Yao MW. (2007) Cell Cycle 6(18):2276-83 [PubMed]

A directed approach for engineering conditional protein stability using biologically silent small molecules.

Maynard-Smith LA, Chen LC, Banaszynski LA, Ooi AG, Wandless TJ. (2007) J. Biol. Chem. 282(34):24866-72 [PubMed]

Suppression of δPKC activation after focal cerebral ischemia contributes to the protective effect of hypothermia.

Shimohata T, Zhao H, Sung JH, Sun G, Mochly-Rosen D, Steinberg GK. (2007) J. Cereb. Blood Flow Metab. 27(8):1463-75 [PubMed]

siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake.

Galvez T, Teruel MN, Heo WD, Jones JT, Kim ML, Liou J, Myers JW, Meyer T. (2007) Genome Biol. 8(7):R142 [PubMed]

Rescue of degradation-prone mutants of the FK506-rapamycin binding (FRB) protein with chemical ligands.

Stankunas K, Bayle JH, Havranek JJ, Wandless TJ, Baker D, Crabtree GR, Gestwicki JE. (2007) Chembiochem 8(10):1162-9 [PubMed]

E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases.

Tyagi S, Chabes AL, Wysocka J, Herr W. (2007) Mol. Cell 27(1):107-19 [PubMed]

Mechanisms of specificity in protein phosphorylation.

Ubersax JA, Ferrell JE. (2007) Nat. Rev. Mol. Cell Biol. 8(7):530-41 [PubMed]

Legal and ethical considerations in the transfusion of infected or untested autologous blood.

Brooks JP, Ferrell JE. (2007) Am. J. Clin. Pathol. 128(1):135-42 [PubMed]

The ATR pathway: fine-tuning the fork.

Paulsen RD, Cimprich KA. (2007) DNA Repair (Amst.) 6(7):953-66 [PubMed]

An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells.

Aoki K, Nakamura T, Inoue T, Meyer T, Matsuda M. (2007) J. Cell Biol. 177(5):817-27 [PubMed]

Happy birthday protein kinase C: past, present and future of a superfamily.

Battaini F, Mochly-Rosen D. (2007) Pharmacol. Res. 55(6):461-6 [PubMed]

Cardioprotective mechanisms of PKC isozyme-selective activators and inhibitors in the treatment of ischemia-reperfusion injury.

Budas GR, Churchill EN, Mochly-Rosen D. (2007) Pharmacol. Res. 55(6):523-36 [PubMed]

Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function.

Kheifets V, Mochly-Rosen D. (2007) Pharmacol. Res. 55(6):467-76 [PubMed]

Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion.

Liou J, Fivaz M, Inoue T, Meyer T. (2007) Proc. Natl. Acad. Sci. U.S.A. 104(22):9301-6 [PubMed]

Engineering small molecule specificity in nearly identical cellular environments.

Sellmyer MA, Stankunas K, Briesewitz R, Crabtree GR, Wandless TJ. (2007) Bioorg. Med. Chem. Lett. 17(10):2703-5 [PubMed]

δPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo.

Bright R, Steinberg GK, Mochly-Rosen D. (2007) Brain Res. 1144:146-55 [PubMed]

The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain.

Edwards SR, Wandless TJ. (2007) J. Biol. Chem. 282(18):13395-401 [PubMed]

Participation of rab5, an early endosome protein, in hepatitis C virus RNA replication machinery.

Stone M, Jia S, Heo WD, Meyer T, Konan KV. (2007) J. Virol. 81(9):4551-63 [PubMed]

SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes.

Berdeaux R, Goebel N, Banaszynski L, Takemori H, Wandless T, Shelton GD, Montminy M. (2007) Nat. Med. 13(5):597-603 [PubMed]

The structural determinants of checkpoint activation.

MacDougall CA, Byun TS, Van C, Yee MC, Cimprich KA. (2007) Genes Dev. 21(8):898-903 [PubMed]

Catch-and-release reagents for broadscale quantitative proteomics analyses.

Gartner CA, Elias JE, Bakalarski CE, Gygi SP. (2007) J. Proteome Res. 6(4):1482-91 [PubMed]

Rational design of a selective antagonist of epsilon protein kinase C derived from the selective allosteric agonist, pseudo-RACK peptide.

Liron T, Chen LE, Khaner H, Vallentin A, Mochly-Rosen D. (2007) J. Mol. Cell. Cardiol. 42(4):835-41 [PubMed]

Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane.

Sano H, Eguez L, Teruel MN, Fukuda M, Chuang TD, Chavez JA, Lienhard GE, McGraw TE. (2007) Cell Metab. 5(4):293-303 [PubMed]

Substrate competition as a source of ultrasensitivity in the inactivation of Wee1.

Kim SY, Ferrell JE. (2007) Cell 128(6):1133-45 [PubMed]

Emi2 at the crossroads: where CSF meets MPF.

Hansen DV, Pomerening JR, Summers MK, Miller JJ, Ferrell JE, Jackson PK. (2007) Cell Cycle 6(6):732-8 [PubMed]

The alliance for cellular signaling plasmid collection: a flexible resource for protein localization studies and signaling pathway analysis.

Zavzavadjian JR, Couture S, Park WS, Whalen J, Lyon S, Lee G, Fung E, Mi Q, Liu J, Wall E, Santat L, Dhandapani K, Kivork C, Driver A, Zhu X, Chang MS, Randhawa B, Gehrig E, Bryan H, Verghese M, Maer A, Saunders B, Ning Y, Subramaniam S, Meyer T, Simon MI, O’Rourke N, Chandy G, Fraser ID. (2007) Mol. Cell Proteomics 6(3):413-24 [PubMed]

Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry.

Elias JE, Gygi SP. (2007) Nat. Methods 4(3):207-14 [PubMed]

Impaired perfusion after myocardial infarction is due to reperfusion-induced δPKC-mediated myocardial damage.

Ikeno F, Inagaki K, Rezaee M, Mochly-Rosen D. (2007) Cardiovasc. Res. 73(4):699-709 [PubMed]

Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.

Li X, Gerber SA, Rudner AD, Beausoleil SA, Haas W, Villén J, Elias JE, Gygi SP. (2007) J. Proteome Res. 6(3):1190-7 [PubMed]

Small-molecule regulation of zebrafish gene expression.

Esengil H, Chang V, Mich JK, Chen JK. (2007) Nat. Chem. Biol. 3(3):154-5 [PubMed]

Tuning bulk electrostatics to regulate protein function.

Serber Z, Ferrell JE. (2007) Cell 128(3):441-4 [PubMed]

Peptides derived from the C2 domain of protein kinase C epsilon (epsilon PKC) modulate epsilon PKC activity and identify potential protein-protein interaction surfaces.

Brandman R, Disatnik MH, Churchill E, Mochly-Rosen D. (2007) J. Biol. Chem. 282(6):4113-23 [PubMed]

Analyzing the ATR-mediated checkpoint using Xenopus egg extracts.

Lupardus PJ, Van C, Cimprich KA. (2007) Methods 41(2):222-31 [PubMed]

A network of Rab GTPases controls phagosome maturation and is modulated by Salmonella enterica serovar Typhimurium.

Smith AC, Heo WD, Braun V, Jiang X, Macrae C, Casanova JE, Scidmore MA, Grinstein S, Meyer T, Brumell JH. (2007) J. Cell Biol. 176(3):263-8 [PubMed]

Use of a novel method to find substrates of protein kinase C delta identifies M2 pyruvate kinase.

Siwko S, Mochly-Rosen D. (2007) Int. J. Biochem. Cell Biol. 39(5):978-87 [PubMed]

Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels.

Suh BC, Inoue T, Meyer T, Hille B. (2006) Science 314(5804):1454-7 [PubMed]

PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane.

Heo WD, Inoue T, Park WS, Kim ML, Park BO, Wandless TJ, Meyer T. (2006) Science 314(5804):1458-61 [PubMed]

Identifying novel proteins recognizing histone modifications using peptide pull-down assay.

Wysocka J. (2006) Methods 40(4):339-43 [PubMed]

Monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires uncoupling of DNA polymerase and mini-chromosome maintenance helicase activities.

Chang DJ, Lupardus PJ, Cimprich KA. (2006) J. Biol. Chem. 281(43):32081-8 [PubMed]

Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2.

Meloni AR, Fralish GB, Kelly P, Salahpour A, Chen JK, Wechsler-Reya RJ, Lefkowitz RJ, Caron MG. (2006) Mol. Cell. Biol. 26(20):7550-60 [PubMed]

A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules.

Banaszynski LA, Chen LC, Maynard-Smith LA, Ooi AG, Wandless TJ. (2006) Cell 126(5):995-1004 [PubMed]

Protein kinase C delta (δPKC)-annexin V interaction: a required step in δPKC translocation and function.

Kheifets V, Bright R, Inagaki K, Schechtman D, Mochly-Rosen D. (2006) J. Biol. Chem. 281(32):23218-26 [PubMed]

Minimizing off-target effects by using diced siRNAs for RNA interference.

Myers JW, Chi JT, Gong D, Schaner ME, Brown PO, Ferrell JE. (2006) J RNAi Gene Silencing 2(2):181-94 [PubMed]

A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling.

Wysocka J, Swigut T, Xiao H, Milne TA, Kwon SY, Landry J, Kauer M, Tackett AJ, Chait BT, Badenhorst P, Wu C, Allis CD. (2006) Nature 442(7098):86-90 [PubMed]

Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF.

Li H, Ilin S, Wang W, Duncan EM, Wysocka J, Allis CD, Patel DJ. (2006) Nature 442(7098):91-5 [PubMed]

Optimization and use of peptide mass measurement accuracy in shotgun proteomics.

Haas W, Faherty BK, Gerber SA, Elias JE, Beausoleil SA, Bakalarski CE, Li X, Villén J, Gygi SP. (2006) Mol. Cell Proteomics 5(7):1326-37 [PubMed]

Mechanistic studies of the mitotic activation of Mos.

Yue J, Ferrell JE. (2006) Mol. Cell. Biol. 26(14):5300-9 [PubMed]

Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling.

Bomgarden RD, Lupardus PJ, Soni DV, Yee MC, Ford JM, Cimprich KA. (2006) EMBO J. 25(11):2605-14 [PubMed]

B-Raf and C-Raf are required for Ras-stimulated p42 MAP kinase activation in Xenopus egg extracts.

Yue J, Xiong W, Ferrell JE. (2006) Oncogene 25(23):3307-15 [PubMed]

Enhanced analysis of metastatic prostate cancer using stable isotopes and high mass accuracy instrumentation.

Everley PA, Bakalarski CE, Elias JE, Waghorne CG, Beausoleil SA, Gerber SA, Faherty BK, Zetter BR, Gygi SP. (2006) J. Proteome Res. 5(5):1224-31 [PubMed]

Epsilon protein kinase C as a potential therapeutic target for the ischemic heart.

Inagaki K, Churchill E, Mochly-Rosen D. (2006) Cardiovasc. Res. 70(2):222-30 [PubMed]

Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus.

Lupardus PJ, Cimprich KA. (2006) Mol. Biol. Cell 17(4):1559-69 [PubMed]

A noisy ‘Start’ to the cell cycle.

Ubersax JA, Ferrell JE. (2006) Mol. Syst. Biol. 2:2006.0014 [PubMed]

Investigating macromolecules inside cultured and injected cells by in-cell NMR spectroscopy.

Serber Z, Selenko P, Hänsel R, Reckel S, Löhr F, Ferrell JE, Wagner G, Dötsch V. (2006) Nat Protoc 1(6):2701-9 [PubMed]

Histone arginine methylation and its dynamic regulation.

Wysocka J, Allis CD, Coonrod S. (2006) Front. Biosci. 11:344-55 [PubMed]

Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

Sinha S, Chen JK. (2006) Nat. Chem. Biol. 2(1):29-30 [PubMed]

Conditional control of protein function.

Banaszynski LA, Wandless TJ. (2006) Chem. Biol. 13(1):11-21 [PubMed]

Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity.

Bayle JH, Grimley JS, Stankunas K, Gestwicki JE, Wandless TJ, Crabtree GR. (2006) Chem. Biol. 13(1):99-107 [PubMed]

Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks.

Sobeck A, Stone S, Costanzo V, de Graaf B, Reuter T, de Winter J, Wallisch M, Akkari Y, Olson S, Wang W, Joenje H, Christian JL, Lupardus PJ, Cimprich KA, Gautier J, Hoatlin ME. (2006) Mol. Cell. Biol. 26(2):425-37 [PubMed]

Multisite M-phase phosphorylation of Xenopus Wee1A.

Kim SY, Song EJ, Lee KJ, Ferrell JE. (2005) Mol. Cell. Biol. 25(23):10580-90 [PubMed]

The role of protein kinase C in cerebral ischemic and reperfusion injury.

Bright R, Mochly-Rosen D. (2005) Stroke 36(12):2781-90 [PubMed]

Interlinked fast and slow positive feedback loops drive reliable cell decisions.

Brandman O, Ferrell JE, Li R, Meyer T. (2005) Science 310(5747):496-8 [PubMed]

Characterization of mouse spleen cells by subtractive proteomics.

Dieguez-Acuna FJ, Gerber SA, Kodama S, Elias JE, Beausoleil SA, Faustman D, Gygi SP. (2005) Mol. Cell Proteomics 4(10):1459-70 [PubMed]

PKC-ε-dependent survival signals in diabetic hearts.

Malhotra A, Begley R, Kang BP, Rana I, Liu J, Yang G, Mochly-Rosen D, Meggs LG. (2005) Am. J. Physiol. Heart Circ. Physiol. 289(4):H1343-50 [PubMed]

Spines and neurite branches function as geometric attractors that enhance protein kinase C action.

Craske ML, Fivaz M, Batada NN, Meyer T. (2005) J. Cell Biol. 170(7):1147-58 [PubMed]

Taking LSD 1 to a new high.

Wysocka J, Milne TA, Allis CD. (2005) Cell 122(5):654-8 [PubMed]

RSA 2004: combined basic research satellite symposium – session three: alcohol and mitochondrial metabolism: at the crossroads of life and death.

Szabo G, Hoek JB, Darley-Usmar V, Hajnoczky G, Knudsen T, Mochly-Rosen D, Zakhari S. (2005) Alcohol. Clin. Exp. Res. 29(9):1749-52 [PubMed]

Comparative evaluation of mass spectrometry platforms used in large-scale proteomics investigations.

Elias JE, Haas W, Faherty BK, Gygi SP. (2005) Nat. Methods 2(9):667-75 [PubMed]

Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations.

Pomerening JR, Kim SY, Ferrell JE. (2005) Cell 122(4):565-78 [PubMed]

A cell-permeable, activity-based probe for protein and lipid kinases.

Yee MC, Fas SC, Stohlmeyer MM, Wandless TJ, Cimprich KA. (2005) J. Biol. Chem. 280(32):29053-9 [PubMed]

Ethanol withdrawal-associated allodynia and hyperalgesia: age-dependent regulation by protein kinase C epsilon and gamma isoenzymes.

Shumilla JA, Liron T, Mochly-Rosen D, Kendig JJ, Sweitzer SM. (2005) J Pain 6(8):535-49 [PubMed]

Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin.

Fivaz M, Meyer T. (2005) J. Cell Biol. 170(3):429-41 [PubMed]

δPKC-mediated activation of εPKC in ethanol-induced cardiac protection from ischemia.

Inagaki K, Mochly-Rosen D. (2005) J. Mol. Cell. Cardiol. 39(2):203-11 [PubMed]

STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.

Liou J, Kim ML, Heo WD, Jones JT, Myers JW, Ferrell JE, Meyer T. (2005) Curr. Biol. 15(13):1235-41 [PubMed]

Reperfusion-induced translocation of δPKC to cardiac mitochondria prevents pyruvate dehydrogenase reactivation.

Churchill EN, Murriel CL, Chen CH, Mochly-Rosen D, Szweda LI. (2005) Circ. Res. 97(1):78-85 [PubMed]

Silencing gene expression with Dicer-generated siRNA pools.

Myers JW, Ferrell JE. (2005) Methods Mol. Biol. 309:93-196 [PubMed]

WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development.

Wysocka J, Swigut T, Milne TA, Dou Y, Zhang X, Burlingame AL, Roeder RG, Brivanlou AH, Allis CD. (2005) Cell 121(6):859-72 [PubMed]

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.

Dou Y, Milne TA, Tackett AJ, Smith ER, Fukuda A, Wysocka J, Allis CD, Chait BT, Hess JL, Roeder RG. (2005) Cell 121(6):873-85 [PubMed]

Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation.

Raval AP, Dave KR, Prado R, Katz LM, Busto R, Sick TJ, Ginsberg MD, Mochly-Rosen D, Pérez-Pinzón MA. (2005) J. Cereb. Blood Flow Metab. 25(6):730-41 [PubMed]

An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways.

Inoue T, Heo WD, Grimley JS, Wandless TJ, Meyer T. (2005) Nat. Methods 2(6):415-8 [PubMed]

Efficient chromosome capture requires a bias in the ‘search-and-capture’ process during mitotic-spindle assembly.

Wollman R, Cytrynbaum EN, Jones JT, Meyer T, Scholey JM, Mogilner A. (2005) Curr. Biol. 15(9):828-32 [PubMed]

The Parkinson’s disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis.

Xu J, Zhong N, Wang H, Elias JE, Kim CY, Woldman I, Pifl C, Gygi SP, Geula C, Yankner BA. (2005) Hum. Mol. Genet. 14(9):1231-41 [PubMed]

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

Byun TS, Pacek M, Yee MC, Walter JC, Cimprich KA. (2005) Genes Dev. 19(9):1040-52 [PubMed]

Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators.

Tanaka M, Gunawan F, Terry RD, Inagaki K, Caffarelli AD, Hoyt G, Tsao PS, Mochly-Rosen D, Robbins RC. (2005) J. Thorac. Cardiovasc. Surg. 129(5):1160-7 [PubMed]

Characterization of the FKBP.rapamycin.FRB ternary complex.

Banaszynski LA, Liu CW, Wandless TJ. (2005) J. Am. Chem. Soc. 127(13):4715-21 [PubMed]

Protein kinase Cγ mediates ethanol withdrawal hyper-responsiveness of NMDA receptor currents in spinal cord motor neurons.

Li HF, Mochly-Rosen D, Kendig JJ. (2005) Br. J. Pharmacol. 144(3):301-7 [PubMed]

A local coupling model and compass parameter for eukaryotic chemotaxis.

Arrieumerlou C, Meyer T. (2005) Dev. Cell 8(2):215-27 [PubMed]

Protein localization studies in the age of ‘Omics’.

O’Rourke NA, Meyer T, Chandy G. (2005) Curr Opin Chem Biol 9(1):82-7 [PubMed]

Cardioprotection by epsilon-protein kinase C activation from ischemia: continuous delivery and antiarrhythmic effect of an epsilon-protein kinase C-activating peptide.

Inagaki K, Begley R, Ikeno F, Mochly-Rosen D. (2005) Circulation 111(1):44-50 [PubMed]

G2 damage checkpoints: what is the turn-on?

O’Connell MJ, Cimprich KA. (2005) J. Cell. Sci. 118(Pt 1):1-6 [PubMed]

Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.

Cheng A, Xiong W, Ferrell JE, Solomon MJ. (2005) Cell Cycle 4(1):155-65 [PubMed]

Allelic variants of the canine heavy neurofilament (NFH) subunit and extensive phosphorylation in dogs with motor neuron disease.

Green SL, Westendorf JM, Jaffe H, Pant HC, Cork LC, Ostrander EA, Vignaux F, Ferrell JE. (2005) J. Comp. Pathol. 132(1):33-50 [PubMed]

Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.

Chen W, Ren XR, Nelson CD, Barak LS, Chen JK, Beachy PA, de Sauvage F, Lefkowitz RJ. (2004) Science 306(5705):2257-60 [PubMed]

Total synthesis of ustiloxin D and considerations on the origin of selectivity of the asymmetric allylic alkylation.

Sawayama AM, Tanaka H, Wandless TJ. (2004) J. Org. Chem. 69(25):8810-20 [PubMed]

Protein kinase Cδ activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria.

Murriel CL, Churchill E, Inagaki K, Szweda LI, Mochly-Rosen D. (2004) J. Biol. Chem. 279(46):47985-91 [PubMed]

Human PAD4 regulates histone arginine methylation levels via demethylimination.

Wang Y, Wysocka J, Sayegh J, Lee YH, Perlin JR, Leonelli L, Sonbuchner LS, McDonald CH, Cook RG, Dou Y, Roeder RG, Clarke S, Stallcup MR, Allis CD, Coonrod SA. (2004) Science 306(5694):279-83 [PubMed]

BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number.

Starita LM, Machida Y, Sankaran S, Elias JE, Griffin K, Schlegel BP, Gygi SP, Parvin JD. (2004) Mol. Cell. Biol. 24(19):8457-66 [PubMed]

Suppression of graft coronary artery disease by a brief treatment with a selective εPKC activator and a δPKC inhibitor in murine cardiac allografts.

Tanaka M, Terry RD, Mokhtari GK, Inagaki K, Koyanagi T, Kofidis T, Mochly-Rosen D, Robbins RC. (2004) Circulation 110(11 Suppl 1):II194-9 [PubMed]

Mos mediates the mitotic activation of p42 MAPK in Xenopus egg extracts.

Yue J, Ferrell JE. (2004) Curr. Biol. 14(17):1581-6 [PubMed]

Simplified analogs of bryostatin with anticancer activity display greater potency for translocation of PKCδ-GFP.

Baryza JL, Brenner SE, Craske ML, Meyer T, Wender PA. (2004) Chem. Biol. 11(9):1261-7 [PubMed]

Picking a winner: new mechanistic insights into the design of effective siRNAs.

Gong D, Ferrell JE. (2004) Trends Biotechnol. 22(9):451-4 [PubMed]

Large-scale characterization of HeLa cell nuclear phosphoproteins.

Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP. (2004) Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-5 [PubMed]

Protein kinase C delta mediates cerebral reperfusion injury in vivo.

Bright R, Raval AP, Dembner JM, Pérez-Pinzón MA, Steinberg GK, Yenari MA, Mochly-Rosen D. (2004) J. Neurosci. 24(31):6880-8 [PubMed]

RACK1 regulates Src-mediated Sam68 and p190RhoGAP signaling.

Miller LD, Lee KC, Mochly-Rosen D, Cartwright CA. (2004) Oncogene 23(33):5682-6 [PubMed]

Cell-specific role for epsilon- and betaI-protein kinase C isozymes in protecting cortical neurons and astrocytes from ischemia-like injury.

Wang J, Bright R, Mochly-Rosen D, Giffard RG. (2004) Neuropharmacology 47(1):136-45 [PubMed]

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.

Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML. (2004) Mol. Cell. Biol. 24(13):5639-49 [PubMed]

Exaggerated nociceptive responses on morphine withdrawal: roles of protein kinase C epsilon and gamma.

Sweitzer SM, Wong SM, Tjolsen A, Allen CP, Mochly-Rosen D, Kendig JJ. (2004) Pain 110(1-2):281-9 [PubMed]

Biodistribution of intracellularly acting peptides conjugated reversibly to Tat.

Begley R, Liron T, Baryza J, Mochly-Rosen D. (2004) Biochem. Biophys. Res. Commun. 318(4):949-54 [PubMed]

Epsilon protein kinase C mediated ischemic tolerance requires activation of the extracellular regulated kinase pathway in the organotypic hippocampal slice.

Lange-Asschenfeldt C, Raval AP, Dave KR, Mochly-Rosen D, Sick TJ, Pérez-Pinzón MA. (2004) J. Cereb. Blood Flow Metab. 24(6):636-45 [PubMed]

SILVER helps assign peptides to tandem mass spectra using intensity-based scoring.

Gibbons FD, Elias JE, Gygi SP, Roth FP. (2004) J. Am. Soc. Mass Spectrom. 15(6):910-2 [PubMed]

Checkpoint adaptation; molecular mechanisms uncovered.

Lupardus PJ, Cimprich KA. (2004) Cell 117(5):555-6 [PubMed]

Quantitative analyses of bifunctional molecules.

Braun PD, Wandless TJ. (2004) Biochemistry 43(18):5406-13 [PubMed]

Protein kinase C epsilon and gamma: involvement in formalin-induced nociception in neonatal rats.

Sweitzer SM, Wong SM, Peters MC, Mochly-Rosen D, Yeomans DC, Kendig JJ. (2004) J. Pharmacol. Exp. Ther. 309(2):616-25 [PubMed]

State-specific monoclonal antibodies identify an intermediate state in epsilon protein kinase C activation.

Souroujon MC, Yao L, Chen H, Endemann G, Khaner H, Geeraert V, Schechtman D, Gordon AS, Diamond I, Mochly-Rosen D. (2004) J. Biol. Chem. 279(17):17617-24 [PubMed]

A critical intramolecular interaction for protein kinase Cε translocation.

Schechtman D, Craske ML, Kheifets V, Meyer T, Schechtman J, Mochly-Rosen D. (2004) J. Biol. Chem. 279(16):15831-40 [PubMed]

A novel protein activity mediates DNA binding of an ATR-ATRIP complex.

Bomgarden RD, Yean D, Yee MC, Cimprich KA. (2004) J. Biol. Chem. 279(14):13346-53 [PubMed]

The neural F-box protein NFB42 mediates the nuclear export of the herpes simplex virus type 1 replication initiator protein (UL9 protein) after viral infection.

Eom CY, Heo WD, Craske ML, Meyer T, Lehman IR. (2004) Proc. Natl. Acad. Sci. U.S.A. 101(12):4036-40 [PubMed]

Probing the precision of the mitotic clock with a live-cell fluorescent biosensor.

Jones JT, Myers JW, Ferrell JE, Meyer T. (2004) Nat. Biotechnol. 22(3):306-12 [PubMed]

Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems.

Angeli D, Ferrell JE, Sontag ED. (2004) Proc. Natl. Acad. Sci. U.S.A. 101(7):1822-7 [PubMed]

Intensity-based protein identification by machine learning from a library of tandem mass spectra.

Elias JE, Gibbons FD, King OD, Roth FP, Gygi SP. (2004) Nat. Biotechnol. 22(2):214-9 [PubMed]

Preservation of base-line hemodynamic function and loss of inducible cardioprotection in adult mice lacking protein kinase C epsilon.

Gray MO, Zhou HZ, Schafhalter-Zoppoth I, Zhu P, Mochly-Rosen D, Messing RO. (2004) J. Biol. Chem. 279(5):3596-604 [PubMed]

Linking covalent histone modifications to epigenetics: the rigidity and plasticity of the marks.

Wang Y, Wysocka J, Perlin JR, Leonelli L, Allis CD, Coonrod SA. (2004) Cold Spring Harb. Symp. Quant. Biol. 69:161-9 [PubMed]

Opposing roles of delta and εPKC in cardiac ischemia and reperfusion: targeting the apoptotic machinery.

Murriel CL, Mochly-Rosen D. (2003) Arch. Biochem. Biophys. 420(2):246-54 [PubMed]

Conditional protein alleles using knockin mice and a chemical inducer of dimerization.

Stankunas K, Bayle JH, Gestwicki JE, Lin YM, Wandless TJ, Crabtree GR. (2003) Mol. Cell 12(6):1615-24 [PubMed]

A positive-feedback-based bistable ‘memory module’ that governs a cell fate decision.

Xiong W, Ferrell JE. (2003) Nature 426(6965):460-5 [PubMed]

Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo.

Inagaki K, Chen L, Ikeno F, Lee FH, Imahashi K, Bouley DM, Rezaee M, Yock PG, Murphy E, Mochly-Rosen D. (2003) Circulation 108(19):2304-7 [PubMed]

Specific localization and timing in neuronal signal transduction mediated by protein-lipid interactions.

Fivaz M, Meyer T. (2003) Neuron 40(2):319-30 [PubMed]

An ultrasensitive Ca2+/calmodulin-dependent protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling.

Bradshaw JM, Kubota Y, Meyer T, Schulman H. (2003) Proc. Natl. Acad. Sci. U.S.A. 100(18):10512-7 [PubMed]

Additive protection of the ischemic heart ex vivo by combined treatment with delta-protein kinase C inhibitor and epsilon-protein kinase C activator.

Inagaki K, Hahn HS, Dorn GW, Mochly-Rosen D. (2003) Circulation 108(7):869-75 [PubMed]

A proteomics approach to understanding protein ubiquitination.

Peng J, Schwartz D, Elias JE, Thoreen CC, Cheng D, Marsischky G, Roelofs J, Finley D, Gygi SP. (2003) Nat. Biotechnol. 21(8):921-6 [PubMed]

Opposing effects of delta- and zeta-protein kinase C isozymes on cardiac fibroblast proliferation: use of isozyme-selective inhibitors.

Braun MU, Mochly-Rosen D. (2003) J. Mol. Cell. Cardiol. 35(8):895-903 [PubMed]

Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII.

Fink CC, Bayer KU, Myers JW, Ferrell JE, Schulman H, Meyer T. (2003) Neuron 39(2):283-97 [PubMed]

PKC isozyme selective regulation of cloned human cardiac delayed slow rectifier K current.

Xiao GQ, Mochly-Rosen D, Boutjdir M. (2003) Biochem. Biophys. Res. Commun. 306(4):1019-25 [PubMed]

Overlay method for detecting protein-protein interactions.

Schechtman D, Murriel C, Bright R, Mochly-Rosen D. (2003) Methods Mol. Biol. 233:351-7 [PubMed]

Glutathione S-transferase pull-down assay.

Schechtman D, Mochly-Rosen D, Ron D. (2003) Methods Mol. Biol. 233:345-50 [PubMed]

Methods for detecting binding proteins: an introduction.

Endemann G, Mochly-Rosen D. (2003) Methods Mol. Biol. 233:307-25 [PubMed]

Prevention of NMDA-induced death of cortical neurons by inhibition of protein kinase Czeta.

Koponen S, Kurkinen K, Akerman KE, Mochly-Rosen D, Chan PH, Koistinaho J. (2003) J. Neurochem. 86(2):442-50 [PubMed]

A bifunctional molecule that displays context-dependent cellular activity.

Braun PD, Barglow KT, Lin YM, Akompong T, Briesewitz R, Ray GT, Haldar K, Wandless TJ. (2003) J. Am. Chem. Soc. 125(25):7575-80 [PubMed]

ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation.

Barr SM, Leung CG, Chang EE, Cimprich KA. (2003) Curr. Biol. 13(12):1047-51 [PubMed]

Enantioselective total synthesis of ustiloxin D.

Tanaka H, Sawayama AM, Wandless TJ. (2003) J. Am. Chem. Soc. 125(23):6864-5 [PubMed]

The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.

Wysocka J, Herr W. (2003) Trends Biochem. Sci. 28(6):294-304 [PubMed]

Switch-of-function mutants based on morphology classification of Ras superfamily small GTPases.

Heo WD, Meyer T. (2003) Cell 113(3):315-28 [PubMed]

Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.

Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W. (2003) Genes Dev. 17(7):896-911 [PubMed]

Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2.

Pomerening JR, Sontag ED, Ferrell JE. (2003) Nat. Cell Biol. 5(4):346-51 [PubMed]

Fragile sites: breaking up over a slowdown.

Cimprich KA. (2003) Curr. Biol. 13(6):R231-3 [PubMed]

Recombinant Dicer efficiently converts large dsRNAs into siRNAs suitable for gene silencing.

Myers JW, Jones JT, Meyer T, Ferrell JE. (2003) Nat. Biotechnol. 21(3):324-8 [PubMed]

The JNK cascade as a biochemical switch in mammalian cells: ultrasensitive and all-or-none responses.

Bagowski CP, Besser J, Frey CR, Ferrell JE. (2003) Curr. Biol. 13(4):315-20 [PubMed]

Cytotoxicity of pEGFP vector is due to residues encoded by multiple cloning site.

Endemann G, Schechtman D, Mochly-Rosen D. (2003) Anal. Biochem. 313(2):345-7 [PubMed]

Single cell imaging of PI3K activity and glucose transporter insertion into the plasma membrane by dual color evanescent wave microscopy.

Tengholm A, Teruel MN, Meyer T. (2003) Sci. STKE 2003(169):PL4 [PubMed]

Enforced proximity in the function of a famous scaffold.

Ferrell JE, Cimprich KA. (2003) Mol. Cell 11(2):289-91 [PubMed]

Fluorescence imaging of signaling networks.

Meyer T, Teruel MN. (2003) Trends Cell Biol. 13(2):101-6 [PubMed]

Epsilon PKC is required for the induction of tolerance by ischemic and NMDA-mediated preconditioning in the organotypic hippocampal slice.

Raval AP, Dave KR, Mochly-Rosen D, Sick TJ, Pérez-Pinzón MA. (2003) J. Neurosci. 23(2):384-91 [PubMed]

Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome.

Peng J, Elias JE, Thoreen CC, Licklider LJ, Gygi SP. (2003) J. Proteome Res. 2(1):43-50 [PubMed]

An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication.

Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M, Gautier J. (2003) Mol. Cell 11(1):203-13 [PubMed]

A Phase II Study of Docetaxel in Patients with Relapsed and Refractory Ewing’s Tumours.

Meyer T, McTiernan A, Whelan J. (2003) Sarcoma 7(1):13-7 [PubMed]

The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins.

Dell EJ, Connor J, Chen S, Stebbins EG, Skiba NP, Mochly-Rosen D, Hamm HE. (2002) J. Biol. Chem. 277(51):49888-95 [PubMed]

Overview of the Alliance for Cellular Signaling.

Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O’Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O’Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR. (2002) Nature 420(6916):703-6 [PubMed]

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.

Chen JK, Taipale J, Cooper MK, Beachy PA. (2002) Genes Dev. 16(21):2743-8 [PubMed]

Small molecule modulation of Smoothened activity.

Chen JK, Taipale J, Young KE, Maiti T, Beachy PA. (2002) Proc. Natl. Acad. Sci. U.S.A. 99(22):14071-6 [PubMed]

A PI3-kinase signaling code for insulin-triggered insertion of glucose transporters into the plasma membrane.

Tengholm A, Meyer T. (2002) Curr. Biol. 12(21):1871-6 [PubMed]

Inactivation of the retinoblastoma protein family can bypass the HCF-1 defect in tsBN67 cell proliferation and cytokinesis.

Reilly PT, Wysocka J, Herr W. (2002) Mol. Cell. Biol. 22(19):6767-78 [PubMed]

Tissue angiotensin II during progression or ventricular hypertrophy to heart failure in hypertensive rats; differential effects on PKC epsilon and PKC beta.

Inagaki K, Iwanaga Y, Sarai N, Onozawa Y, Takenaka H, Mochly-Rosen D, Kihara Y. (2002) J. Mol. Cell. Cardiol. 34(10):1377-85 [PubMed]

A requirement for replication in activation of the ATR-dependent DNA damage checkpoint.

Lupardus PJ, Byun T, Yee MC, Hekmat-Nejad M, Cimprich KA. (2002) Genes Dev. 16(18):2327-32 [PubMed]

Medulloblastoma growth inhibition by hedgehog pathway blockade.

Berman DM, Karhadkar SS, Hallahan AR, Pritchard JI, Eberhart CG, Watkins DN, Chen JK, Cooper MK, Taipale J, Olson JM, Beachy PA. (2002) Science 297(5586):1559-61 [PubMed]

Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts.

Jin ZQ, Zhou HZ, Zhu P, Honbo N, Mochly-Rosen D, Messing RO, Goetzl EJ, Karliner JS, Gray MO. (2002) Am. J. Physiol. Heart Circ. Physiol. 282(6):H1970-7 [PubMed]

Molecular mechanisms of CaMKII activation in neuronal plasticity.

Fink CC, Meyer T. (2002) Curr. Opin. Neurobiol. 12(3):293-9 [PubMed]

Sequential activation of individual PKC isozymes in integrin-mediated muscle cell spreading: a role for MARCKS in an integrin signaling pathway.

Disatnik MH, Boutet SC, Lee CH, Mochly-Rosen D, Rando TA. (2002) J. Cell. Sci. 115(Pt 10):2151-63 [PubMed]

Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon.

Knauf JA, Ward LS, Nikiforov YE, Nikiforova M, Puxeddu E, Medvedovic M, Liron T, Mochly-Rosen D, Fagin JA. (2002) J. Clin. Endocrinol. Metab. 87(5):2150-9 [PubMed]

Molecular dynamics characterization of the C2 domain of protein kinase Cβ.

Banci L, Cavallaro G, Kheifets V, Mochly-Rosen D. (2002) J. Biol. Chem. 277(15):12988-97 [PubMed]

Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability.

Ferrell JE. (2002) Curr. Opin. Cell Biol. 14(2):140-8 [PubMed]

Dopamine-induced exocytosis of Na,K-ATPase is dependent on activation of protein kinase C-ε and –δ.

Ridge KM, Dada L, Lecuona E, Bertorello AM, Katz AI, Mochly-Rosen D, Sznajder JI. (2002) Mol. Biol. Cell 13(4):1381-9 [PubMed]

Parallel single-cell monitoring of receptor-triggered membrane translocation of a calcium-sensing protein module.

Teruel MN, Meyer T. (2002) Science 295(5561):1910-2 [PubMed]

Moderate alcohol exposure protects cardiac myocytes from ischemia-reperfusion injury.

Gray MO, Mochly-Rosen D. In Alcohol and Heart Disease. Watson RR, Myers AK (eds). Taylor and Francis, New York, pp 104-113, 2002.

Intracellular transport mechanisms of signal transducers.

Dorn GW, Mochly-Rosen D. (2002) Annu. Rev. Physiol. 64:407-29 [PubMed]

Activation of p42 mitogen-activated protein kinase (MAPK), but not c-Jun NH(2)-terminal kinase, induces phosphorylation and stabilization of MAPK phosphatase XCL100 in Xenopus oocytes.

Sohaskey ML, Ferrell JE. (2002) Mol. Biol. Cell 13(2):454-68 [PubMed]

Isozyme-specific inhibitors and activators of protein kinase C.

Schechtman D, Mochly-Rosen D. (2002) Meth. Enzymol. 345:470-89 [PubMed]

Multisite phosphorylation and the countdown to S phase.

Deshaies RJ, Ferrell JE. (2001) Cell 107(7):819-22 [PubMed]

Molecular transporters for peptides: delivery of a cardioprotective εPKC agonist peptide into cells and intact ischemic heart using a transport system, R(7).

Chen L, Wright LR, Chen CH, Oliver SF, Wender PA, Mochly-Rosen D. (2001) Chem. Biol. 8(12):1123-9 [PubMed]

Six steps to destruction.

Ferrell JE. (2001) Nature 414(6863):498-9 [PubMed]

Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage.

Post S, Weng YC, Cimprich K, Chen LB, Xu Y, Lee EY. (2001) Proc. Natl. Acad. Sci. U.S.A. 98(23):13102-7 [PubMed]

Evidence for functional role of εPKC isozyme in the regulation of cardiac Na(+) channels.

Xiao GQ, Qu Y, Sun ZQ, Mochly-Rosen D, Boutjdir M. (2001) Am. J. Physiol., Cell Physiol. 281(5):C1477-86 [PubMed]

The classical progesterone receptor associates with p42 MAPK and is involved in phosphatidylinositol 3-kinase signaling in Xenopus oocytes.

Bagowski CP, Myers JW, Ferrell JE. (2001) J. Biol. Chem. 276(40):37708-14 [PubMed]

Adaptor proteins in protein kinase C-mediated signal transduction.

Schechtman D, Mochly-Rosen D. (2001) Oncogene 20(44):6339-47 [PubMed]

Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC.

Chen L, Hahn H, Wu G, Chen CH, Liron T, Schechtman D, Cavallaro G, Banci L, Guo Y, Bolli R, Dorn GW, Mochly-Rosen D. (2001) Proc. Natl. Acad. Sci. U.S.A. 98(20):11114-9 [PubMed]

Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C.

Stebbins EG, Mochly-Rosen D. (2001) J. Biol. Chem. 276(32):29644-50 [PubMed]

Bistability in the JNK cascade.

Bagowski CP, Ferrell JE. (2001) Curr. Biol. 11(15):1176-82 [PubMed]

Control of astrocyte Ca(2+) oscillations and waves by oscillating translocation and activation of protein kinase C.

Codazzi F, Teruel MN, Meyer T. (2001) Curr. Biol. 11(14):1089-97 [PubMed]

Localization, anchoring, and functions of protein kinase C isozymes in the heart.

Mackay K, Mochly-Rosen D. (2001) J. Mol. Cell. Cardiol. 33(7):1301-7 [PubMed]

Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis.

Marshall JG, Booth JW, Stambolic V, Mak T, Balla T, Schreiber AD, Meyer T, Grinstein S. (2001) J. Cell Biol. 153(7):1369-80 [PubMed]

Loss of HCF-1-chromatin association precedes temperature-induced growth arrest of tsBN67 cells.

Wysocka J, Reilly PT, Herr W. (2001) Mol. Cell. Biol. 21(11):3820-9 [PubMed]

Spontaneous occurrence of an inhibitor of protein kinase C localization in a thyroid cancer cell line: role in thyroid tumorigenesis.

Mochly-Rosen D, Fagin JA, Knauf JA, Nikiforov Y, Liron T, Schechtman D. (2001) Adv. Enzyme Regul. 41:87-97 [PubMed]

Developmental and cell-cycle regulation of Caenorhabditis elegans HCF phosphorylation.

Wysocka J, Liu Y, Kobayashi R, Herr W. (2001) Biochemistry 40(19):5786-94 [PubMed]

Calcineurin inhibitors and the generalization of the presenting protein strategy.

Vogel KW, Briesewitz R, Wandless TJ, Crabtree GR. (2001) Adv. Protein Chem. 56:253-91 [PubMed]

Arachidonic acid protects neonatal rat cardiac myocytes from ischaemic injury through epsilon protein kinase C.

Mackay K, Mochly-Rosen D. (2001) Cardiovasc. Res. 50(1):65-74 [PubMed]

Subcellular targeting by membrane lipids.

Hurley JH, Meyer T. (2001) Curr. Opin. Cell Biol. 13(2):146-52 [PubMed]

Opposing effects of delta and xi PKC in ethanol-induced cardioprotection.

Chen C, Mochly-Rosen D. (2001) J. Mol. Cell. Cardiol. 33(3):581-5 [PubMed]

Bistability in cell signaling: How to make continuous processes discontinuous, and reversible processes irreversible.

Ferrell JE, Xiong W. (2001) Chaos 11(1):227-236 [PubMed]

c-Jun N-terminal kinase activation in Xenopus laevis eggs and embryos. A possible non-genomic role for the JNK signaling pathway.

Bagowski CP, Xiong W, Ferrell JE. (2001) J. Biol. Chem. 276(2):1459-65 [PubMed]

Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis.

Botelho RJ, Teruel M, Dierckman R, Anderson R, Wells A, York JD, Meyer T, Grinstein S. (2000) J. Cell Biol. 151(7):1353-68 [PubMed]

Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint.

Hekmat-Nejad M, You Z, Yee MC, Newport JW, Cimprich KA. (2000) Curr. Biol. 10(24):1565-73 [PubMed]

Spatial sensing in fibroblasts mediated by 3′ phosphoinositides.

Haugh JM, Codazzi F, Teruel M, Meyer T. (2000) J. Cell Biol. 151(6):1269-80 [PubMed]

Synthesis of flavonol derivatives as probes of biological processes.

Tanaka H, Stohlmeyer MM, Wandless TJ, Taylor LP. (2000) Tetrahedron Letters 41:9735-9739. [PDF]

Evidence for functional role of εPKC isozyme in the regulation of cardiac Ca(2+) channels.

Hu K, Mochly-Rosen D, Boutjdir M. (2000) Am. J. Physiol. Heart Circ. Physiol. 279(6):H2658-64 [PubMed]

Disease attributed to Mycobacterium chelonae in South African clawed frogs (Xenopus laevis).

Green SL, Lifland BD, Bouley DM, Brown BA, Wallace RJ, Ferrell JE. (2000) Comp. Med. 50(6):675-9 [PubMed]

Mechanistic studies of affinity modulation.

Rosen MK, Amos CD, Wandless TJ. (2000) J. Am. Chem. Soc. 122:11979-11982 [PDF]

Studies of signal transduction events using chimeras to green fluorescent protein.

Meyer T, Oancea E. (2000) Meth. Enzymol. 327:500-13 [PubMed]

Cloning and characterization of Xenopus Rsk2, the predominant p90 Rsk isozyme in oocytes and eggs.

Bhatt RR, Ferrell JE. (2000) J. Biol. Chem. 275(42):32983-90 [PubMed]

Translocation and reversible localization of signaling proteins: a dynamic future for signal transduction.

Teruel MN, Meyer T. (2000) Cell 103(2):181-4 [PubMed]

What do scaffold proteins really do?

Ferrell JE. (2000) Sci. STKE 2000(52):pe1 [PubMed]

Protein kinase C isozymes and the regulation of diverse cell responses.

Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO. (2000) Am. J. Physiol. Lung Cell Mol. Physiol. 279(3):L429-38 [PubMed]

Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II.

Shen K, Teruel MN, Connor JH, Shenolikar S, Meyer T. (2000) Nat. Neurosci. 3(9):881-6 [PubMed]

Inhibition of progesterone-induced Xenopus oocyte maturation by Nm23.

Kim SY, Ferrell JE, Chae SK, Lee KJ. (2000) Cell Growth Differ. 11(9):485-90 [PubMed]

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.

Taipale J, Chen JK, Cooper MK, Wang B, Mann RK, Milenkovic L, Scott MP, Beachy PA. (2000) Nature 406(6799):1005-9 [PubMed]

Involvement of a p38 mitogen-activated protein kinase phosphatase in protecting neonatal rat cardiac myocytes from ischemia.

Mackay K, Mochly-Rosen D. (2000) J. Mol. Cell. Cardiol. 32(8):1585-8 [PubMed]

A confederacy of bunches: fundamentals and applications of a self-associating protein.

Wandless TJ. (2000) Proc. Natl. Acad. Sci. U.S.A. 97(13):6921-3 [PubMed]

Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C.

Aley KO, Messing RO, Mochly-Rosen D, Levine JD. (2000) J. Neurosci. 20(12):4680-5 [PubMed]

Cardiotrophic effects of protein kinase C epsilon: analysis by in vivo modulation of PKCε translocation.

Mochly-Rosen D, Wu G, Hahn H, Osinska H, Liron T, Lorenz JN, Yatani A, Robbins J, Dorn GW. (2000) Circ. Res. 86(11):1173-9 [PubMed]

In and out of the postsynaptic region: signalling proteins on the move.

Meyer T, Shen K. (2000) Trends Cell Biol. 10(6):238-44 [PubMed]

Activation of Wee1 by p42 MAPK in vitro and in cycling xenopus egg extracts.

Walter SA, Guadagno SN, Ferrell JE. (2000) Mol. Biol. Cell 11(3):887-96 [PubMed]

Synthesis and evaluation of daunorubicin-paclitaxel dimers.

Kar AK, Braun PD, Wandless TJ. (2000) Bioorg. Med. Chem. Lett. 10(3):261-4 [PubMed]

Pharmacological regulation of network kinetics by protein kinase C localization.

Mochly-Rosen D, Kauvar LM. (2000) Semin. Immunol. 12(1):55-61 [PubMed]

Differential codes for free Ca(2+)-calmodulin signals in nucleus and cytosol.

Teruel MN, Chen W, Persechini A, Meyer T. (2000) Curr. Biol. 10(2):86-94 [PubMed]

Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion.

Raucher D, Stauffer T, Chen W, Shen K, Guo S, York JD, Sheetz MP, Meyer T. (2000) Cell 100(2):221-8 [PubMed]

The protein kinase p90 rsk as an essential mediator of cytostatic factor activity.

Bhatt RR, Ferrell JE. (1999) Science 286(5443):1362-5 [PubMed]

Distinct, constitutively active MAPK phosphatases function in Xenopus oocytes: implications for p42 MAPK regulation In vivo.

Sohaskey ML, Ferrell JE. (1999) Mol. Biol. Cell 10(11):3729-43 [PubMed]

A versatile microporation technique for the transfection of cultured CNS neurons.

Teruel MN, Blanpied TA, Shen K, Augustine GJ, Meyer T. (1999) J. Neurosci. Methods 93(1):37-48 [PubMed]

Cardioprotection from ischemia by a brief exposure to physiological levels of ethanol: role of epsilon protein kinase C.

Chen CH, Gray MO, Mochly-Rosen D. (1999) Proc. Natl. Acad. Sci. U.S.A. 96(22):12784-9 [PubMed]

Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation.

Dorn GW, Souroujon MC, Liron T, Chen CH, Gray MO, Zhou HZ, Csukai M, Wu G, Lorenz JN, Mochly-Rosen D. (1999) Proc. Natl. Acad. Sci. U.S.A. 96(22):12798-803 [PubMed]

RACK1, a protein kinase C anchoring protein, coordinates the binding of activated protein kinase C and select pleckstrin homology domains in vitro.

Rodriguez MM, Ron D, Touhara K, Chen CH, Mochly-Rosen D. (1999) Biochemistry 38(42):13787-94 [PubMed]

Xenopus oocyte maturation: new lessons from a good egg.

Ferrell JE. (1999) Bioessays 21(10):833-42 [PubMed]

Building a cellular switch: more lessons from a good egg.

Ferrell JE. (1999) Bioessays 21(10):866-70 [PubMed]

Protein kinase C-ε is responsible for the protection of preconditioning in rabbit cardiomyocytes.

Liu GS, Cohen MV, Mochly-Rosen D, Downey JM. (1999) J. Mol. Cell. Cardiol. 31(10):1937-48 [PubMed]

An efficient synthesis of β,γ-dehydrovaline.

Woiwode TF, Wandless TJ. (1999) J. Org. Chem. 64:7670-7674 [PDF]

Involvement of protein kinase Cε (PKCε) in thyroid cell death. A truncated chimeric PKCε cloned from a thyroid cancer cell line protects thyroid cells from apoptosis.

Knauf JA, Elisei R, Mochly-Rosen D, Liron T, Chen XN, Gonsky R, Korenberg JR, Fagin JA. (1999) J. Biol. Chem. 274(33):23414-25 [PubMed]

Characterization of the binding and phosphorylation of cardiac calsequestrin by epsilon protein kinase C.

Rodriguez MM, Chen CH, Smith BL, Mochly-Rosen D. (1999) FEBS Lett. 454(3):240-6 [PubMed]

Identification and management of an outbreak of Flavobacterium meningosepticum infection in a colony of South African clawed frogs (Xenopus laevis).

Green SL, Bouley DM, Tolwani RJ, Waggie KS, Lifland BD, Otto GM, Ferrell JE. (1999) J. Am. Vet. Med. Assoc. 214(12):1833-8, 1792-3 [PubMed]

A stereospecific elimination to form dehydroamino acids: synthesis of the phomopsin tripeptide sidechain.

Stohlmeyer MM, Tanaka H, Wandless TJ. (1999) J. Am. Chem. Soc. 121:6100-6101 [PDF]

M phase phosphorylation of cytoplasmic dynein intermediate chain and p150(Glued).

Huang CY, Chang CP, Huang CL, Ferrell JE. (1999) J. Biol. Chem. 274(20):14262-9 [PubMed]

Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium.

Improta-Brears T, Whorton AR, Codazzi F, York JD, Meyer T, McDonnell DP. (1999) Proc. Natl. Acad. Sci. U.S.A. 96(8):4686-91 [PubMed]

Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation.

Shen K, Meyer T. (1999) Science 284(5411):162-6 [PubMed]

Pharmacologic modulation of protein kinase C isozymes: the role of RACKs and subcellular localisation.

Csukai M, Mochly-Rosen D. (1999) Pharmacol. Res. 39(4):253-9 [PubMed]

An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia.

Mackay K, Mochly-Rosen D. (1999) J. Biol. Chem. 274(10):6272-9 [PubMed]

Affinity modulation of small-molecule ligands by borrowing endogenous protein surfaces.

Briesewitz R, Ray GT, Wandless TJ, Crabtree GR. (1999) Proc. Natl. Acad. Sci. U.S.A. 96(5):1953-8 [PubMed]

Characterization of a dextran-based bifunctional calcium indicator immobilized in cells by the enzymatic addition of isoprenoid lipids.

Horne JH, Meyer T. (1999) Cell Calcium 25(1):1-7 [PubMed]

How regulated protein translocation can produce switch-like responses.

Ferrell JE. (1998) Trends Biochem. Sci. 23(12):461-5 [PubMed]

A Simple and Efficient Method for the Preparation of Hindered Alkyl-Aryl Ethers.

Woiwode TF, Rose C, Wandless TJ. (1998) J. Org. Chem. 63:9594-9596 [PDF]

Requirement for MAPK activation for normal mitotic progression in Xenopus egg extracts.

Guadagno TM, Ferrell JE. (1998) Science 282(5392):1312-5 [PubMed]

Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis.

Laudanna C, Mochly-Rosen D, Liron T, Constantin G, Butcher EC. (1998) J. Biol. Chem. 273(46):30306-15 [PubMed]

Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals.

Oancea E, Meyer T. (1998) Cell 95(3):307-18 [PubMed]

Peptide modulators of protein-protein interactions in intracellular signaling.

Souroujon MC, Mochly-Rosen D. (1998) Nat. Biotechnol. 16(10):919-24 [PubMed]

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.

Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD. (1998) Science 281(5383):1677-9 [PubMed]

CaMKIIbeta functions as an F-actin targeting module that localizes CaMKIIalpha/beta heterooligomers to dendritic spines.

Shen K, Teruel MN, Subramanian K, Meyer T. (1998) Neuron 21(3):593-606 [PubMed]

Molecular genetic approaches. II. Expression-interaction cloning.

Csukai M, Mochly-Rosen D. (1998) Methods Mol. Biol. 88:133-9 [PubMed]

Activation of epsilon protein kinase C correlates with a cardioprotective effect of regular ethanol consumption.

Miyamae M, Rodriguez MM, Camacho SA, Diamond I, Mochly-Rosen D, Figueredo VM. (1998) Proc. Natl. Acad. Sci. U.S.A. 95(14):8262-7 [PubMed]

Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt.

Kontos CD, Stauffer TP, Yang WP, York JD, Huang L, Blanar MA, Meyer T, Peters KG. (1998) Mol. Cell. Biol. 18(7):4131-40 [PubMed]

The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes.

Ferrell JE, Machleder EM. (1998) Science 280(5365):895-8 [PubMed]

Visualization of dynamic trafficking of a protein kinase C betaII/green fluorescent protein conjugate reveals differences in G protein-coupled receptor activation and desensitization.

Feng X, Zhang J, Barak LS, Meyer T, Caron MG, Hannun YA. (1998) J. Biol. Chem. 273(17):10755-62 [PubMed]

Modulating protein kinase C signal transduction.

Mochly-Rosen D, Kauvar LM. (1998) Adv. Pharmacol. 44:91-145 [PubMed]

Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells.

Stauffer TP, Ahn S, Meyer T. (1998) Curr. Biol. 8(6):343-6 [PubMed]

Green fluorescent protein (GFP)-tagged cysteine-rich domains from protein kinase C as fluorescent indicators for diacylglycerol signaling in living cells.

Oancea E, Teruel MN, Quest AF, Meyer T. (1998) J. Cell Biol. 140(3):485-98 [PubMed]

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints.

Cliby WA, Roberts CJ, Cimprich KA, Stringer CM, Lamb JR, Schreiber SL, Friend SH. (1998) EMBO J. 17(1):159-69 [PubMed]

Anchoring proteins for protein kinase C: a means for isozyme selectivity.

Mochly-Rosen D, Gordon AS. (1998) FASEB J. 12(1):35-42 [PubMed]

In vivo and in vitro characterization of the sequence requirement for oligomer formation of Ca2+/calmodulin-dependent protein kinase IIalpha.

Shen K, Meyer T. (1998) J. Neurochem. 70(1):96-104 [PubMed]

Compartmentalized IgE receptor-mediated signal transduction in living cells.

Stauffer TP, Meyer T. (1997) J. Cell Biol. 139(6):1447-54 [PubMed]

A selective epsilon-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death.

Gray MO, Karliner JS, Mochly-Rosen D. (1997) J. Biol. Chem. 272(49):30945-51 [PubMed]

Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking.

Thissen JA, Gross JM, Subramanian K, Meyer T, Casey PJ. (1997) J. Biol. Chem. 272(48):30362-70 [PubMed]

The coatomer protein beta’-COP, a selective binding protein (RACK) for protein kinase Cε.

Csukai M, Chen CH, De Matteis MA, Mochly-Rosen D. (1997) J. Biol. Chem. 272(46):29200-6 [PubMed]

Induction of a G2-phase arrest in Xenopus egg extracts by activation of p42 mitogen-activated protein kinase.

Walter SA, Guadagno TM, Ferrell JE. (1997) Mol. Biol. Cell 8(11):2157-69 [PubMed]

Electroporation-induced formation of individual calcium entry sites in the cell body and processes of adherent cells.

Teruel MN, Meyer T. (1997) Biophys. J. 73(4):1785-96 [PubMed]

Inhibition of Lyn function in mast cell activation by SH3 domain binding peptides.

Stauffer TP, Martenson CH, Rider JE, Kay BK, Meyer T. (1997) Biochemistry 36(31):9388-94 [PubMed]

How responses get more switch-like as you move down a protein kinase cascade.

Ferrell JE. (1997) Trends Biochem. Sci. 22(8):288-9 [PubMed]

Mechanistic studies of the dual phosphorylation of mitogen-activated protein kinase.

Ferrell JE, Bhatt RR. (1997) J. Biol. Chem. 272(30):19008-16 [PubMed]

Calcium-induced restructuring of nuclear envelope and endoplasmic reticulum calcium stores.

Subramanian K, Meyer T. (1997) Cell 89(6):963-71 [PubMed]

Elementary calcium-release units induced by inositol trisphosphate.

Horne JH, Meyer T. (1997) Science 276(5319):1690-3 [PubMed]

An inhibitory fragment derived from protein kinase Cε prevents enhancement of nerve growth factor responses by ethanol and phorbol esters.

Hundle B, McMahon T, Dadgar J, Chen CH, Mochly-Rosen D, Messing RO. (1997) J. Biol. Chem. 272(23):15028-35 [PubMed]

Control of action potential-induced Ca2+ signaling in the soma of hippocampal neurons by Ca2+ release from intracellular stores.

Jacobs JM, Meyer T. (1997) J. Neurosci. 17(11):4129-35 [PubMed]

C2 region-derived peptides of beta-protein kinase C regulate cardiac Ca2+ channels.

Zhang ZH, Johnson JA, Chen L, El-Sherif N, Mochly-Rosen D, Boutjdir M. (1997) Circ. Res. 80(5):720-9 [PubMed]

A role for mitogen-activated protein kinase in the spindle assembly checkpoint in XTC cells.

Wang XM, Zhai Y, Ferrell JE. (1997) J. Cell Biol. 137(2):433-43 [PubMed]

Internal trafficking and surface mobility of a functionally intact beta2-adrenergic receptor-green fluorescent protein conjugate.

Barak LS, Ferguson SS, Zhang J, Martenson C, Meyer T, Caron MG. (1997) Mol. Pharmacol. 51(2):177-84 [PubMed]

Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic beta-cells.

Yedovitzky M, Mochly-Rosen D, Johnson JA, Gray MO, Ron D, Abramovitch E, Cerasi E, Nesher R. (1997) J. Biol. Chem. 272(3):1417-20 [PubMed]

Expression-interaction cloning.

Csukai M, Mochly-Rosen D. In Methods in Molecular Biology: Protein Targeting Protocols. R.A. Clegg (ed). Humana Press, Inc., Totowa, NJ, pp 133-139, 1997.

An improved permeabilization protocol for the introduction of peptides into cardiac myocytes. Application to protein kinase C research.

Johnson JA, Gray MO, Karliner JS, Chen CH, Mochly-Rosen D. (1996) Circ. Res. 79(6):1086-99 [PubMed]

Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs.

Ferrell JE. (1996) Trends Biochem. Sci. 21(12):460-6 [PubMed]

Ethanol and signal transduction in the myocardium: implications for the detrimental and beneficial effects.

Figueredo VM, Mochly-Rosen D. In Alcohol and the Cardiovascular System. Zakhari S and Wassef M (eds). CSR, Inc., Washington, DC pp 263-277, 1996.

A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function.

Johnson JA, Gray MO, Chen CH, Mochly-Rosen D. (1996) J. Biol. Chem. 271(40):24962-6 [PubMed]

Spatial dynamics of GFP-tagged proteins investigated by local fluorescence enhancement.

Yokoe H, Meyer T. (1996) Nat. Biotechnol. 14(10):1252-6 [PubMed]

Ultrasensitivity in the mitogen-activated protein kinase cascade.

Huang CY, Ferrell JE. (1996) Proc. Natl. Acad. Sci. U.S.A. 93(19):10078-83 [PubMed]

Differential activation of protein kinase C isozymes by phorbol ester and collagen in human skin microvascular endothelial cells.

Zhou LY, Disatnik M, Herron GS, Mochly-Rosen D, Karasek MA. (1996) J. Invest. Dermatol. 107(2):248-52 [PubMed]

Reversible desensitization of inositol trisphosphate-induced calcium release provides a mechanism for repetitive calcium spikes.

Oancea E, Meyer T. (1996) J. Biol. Chem. 271(29):17253-60 [PubMed]

The HIV nef protein associates with protein kinase C theta.

Smith BL, Krushelnycky BW, Mochly-Rosen D, Berg P. (1996) J. Biol. Chem. 271(28):16753-7 [PubMed]

Signal transduction by the polymeric immunoglobulin receptor suggests a role in regulation of receptor transcytosis.

Cardone MH, Smith BL, Mennitt PA, Mochly-Rosen D, Silver RB, Mostov KE. (1996) J. Cell Biol. 133(5):997-1005 [PubMed]

Dependence of Mos-induced Cdc2 activation on MAP kinase function in a cell-free system.

Huang CY, Ferrell JE. (1996) EMBO J. 15(9):2169-73 [PubMed]

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.

Cimprich KA, Shin TB, Keith CT, Schreiber SL. (1996) Proc. Natl. Acad. Sci. U.S.A. 93(7):2850-5 [PubMed]

SH2 domains: a question of independence.

Wandless TJ. (1996) Curr. Biol. 6(2):125-7 [PubMed]

MAP kinases in mitogenesis and development.

Ferrell JE. (1996) Curr. Top. Dev. Biol. 33:1-60 [PubMed]

Stimulus-dependent subcellular localization of activated protein kinase C; a study with acidic fibroblast growth factor and transforming growth factor-beta 1 in cardiac myocytes.

Disatnik MH, Jones SN, Mochly-Rosen D. (1995) J. Mol. Cell. Cardiol. 27(11):2473-81 [PubMed]

C2 region-derived peptides inhibit translocation and function of beta protein kinase C in vivo.

Ron D, Luo J, Mochly-Rosen D. (1995) J. Biol. Chem. 270(41):24180-7 [PubMed]

Luminal calcium regulates the inositol trisphosphate receptor of rat basophilic leukemia cells at a cytosolic site.

Horne JH, Meyer T. (1995) Biochemistry 34(39):12738-46 [PubMed]

The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor.

Brzoska PM, Chen H, Zhu Y, Levin NA, Disatnik MH, Mochly-Rosen D, Murnane JP, Christman MF. (1995) Proc. Natl. Acad. Sci. U.S.A. 92(17):7824-8 [PubMed]

Interaction of protein kinase C with RACK1, a receptor for activated C-kinase: a role in beta protein kinase C mediated signal transduction.

Mochly-Rosen D, Smith BL, Chen CH, Disatnik MH, Ron D. (1995) Biochem. Soc. Trans. 23(3):596-600 [PubMed]

Localized calcium signals in early zebrafish development.

Reinhard E, Yokoe H, Niebling KR, Allbritton NL, Kuhn MA, Meyer T. (1995) Dev. Biol. 170(1):50-61 [PubMed]

Localization of protein kinases by anchoring proteins: a theme in signal transduction.

Mochly-Rosen D. (1995) Science 268(5208):247-51 [PubMed]

Inhibition of the spontaneous rate of contraction of neonatal cardiac myocytes by protein kinase C isozymes. A putative role for the epsilon isozyme.

Johnson JA, Mochly-Rosen D. (1995) Circ. Res. 76(4):654-63 [PubMed]

Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domains.

Pluskey S, Wandless TJ, Walsh CT, Shoelson SE. (1995) J. Biol. Chem. 270(7):2897-900 [PubMed]

An autoregulatory region in protein kinase C: the pseudoanchoring site.

Ron D, Mochly-Rosen D. (1995) Proc. Natl. Acad. Sci. U.S.A. 92(2):492-6 [PubMed]

Prolonged phorbol ester treatment down-regulates protein kinase C isozymes and increases contraction rate in neonatal cardiac myocytes.

Johnson JA, Adak S, Mochly-Rosen D. (1995) Life Sci. 57(11):1027-38 [PubMed]

Regulation of nuclear calcium concentration.

Meyer T, Allbritton NL, Oancea E. (1995) Ciba Found. Symp. 188:252-62; discussion 262-6 [PubMed]

Source of nuclear calcium signals.

Allbritton NL, Oancea E, Kuhn MA, Meyer T. (1994) Proc. Natl. Acad. Sci. U.S.A. 91(26):12458-62 [PubMed]

Agonists and antagonists of protein kinase C function, derived from its binding proteins.

Ron D, Mochly-Rosen D. (1994) J. Biol. Chem. 269(34):21395-8 [PubMed]

Distinct responses of protein kinase C isozymes to c-erbB-2 activation in SKBR-3 human breast carcinoma cells.

Disatnik MH, Winnier AR, Mochly-Rosen D, Arteaga CL. (1994) Cell Growth Differ. 5(8):873-80 [PubMed]

Developmental expression of protein kinase C subspecies in rat brain-pituitary axis.

Garcia-Navarro S, Marantz Y, Eyal R, Kalina M, Disatnik MH, Mochly-Rosen D, Ben-Menahem D, Reiss N, Naor Z. (1994) Mol. Cell. Endocrinol. 103(1-2):133-8 [PubMed]

Evidence that inactive p42 mitogen-activated protein kinase and inactive Rsk exist as a heterodimer in vivo.

Hsiao KM, Chou SY, Shih SJ, Ferrell JE. (1994) Proc. Natl. Acad. Sci. U.S.A. 91(12):5480-4 [PubMed]

Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1.

Sugimoto S, Wandless TJ, Shoelson SE, Neel BG, Walsh CT. (1994) J. Biol. Chem. 269(18):13614-22 [PubMed]

Dual role of calmodulin in autophosphorylation of multifunctional CaM kinase may underlie decoding of calcium signals.

Hanson PI, Meyer T, Stryer L, Schulman H. (1994) Neuron 12(5):943-56 [PubMed]

Phorbol myristate acetate-mediated stimulation of transcytosis and apical recycling in MDCK cells.

Cardone MH, Smith BL, Song W, Mochly-Rosen D, Mostov KE. (1994) J. Cell Biol. 124(5):717-27 [PubMed]

Localization of protein kinase C isozymes in cardiac myocytes.

Disatnik MH, Buraggi G, Mochly-Rosen D. (1994) Exp. Cell Res. 210(2):287-97 [PubMed]

Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins.

Ron D, Chen CH, Caldwell J, Jamieson L, Orr E, Mochly-Rosen D. (1994) Proc. Natl. Acad. Sci. U.S.A. 91(3):839-43 [PubMed]

Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C.

Disatnik MH, Hernandez-Sotomayor SM, Jones G, Carpenter G, Mochly-Rosen D. (1994) Proc. Natl. Acad. Sci. U.S.A. 91(2):559-63 [PubMed]

Controlling signal transduction with synthetic ligands.

Spencer DM, Wandless TJ, Schreiber SL, Crabtree GR. (1993) Science 262(5136):1019-24 [PubMed]

Localized calcium spikes and propagating calcium waves.

Allbritton NL, Meyer T. (1993) Cell Calcium 14(10):691-7 [PubMed]

Use of intracellular Ca2+ stores from rat basophilic leukemia cells to study the molecular mechanism leading to quantal Ca2+ release by inositol 1,4,5-trisphosphate.

Kindman LA, Meyer T. (1993) Biochemistry 32(5):1270-7 [PubMed]

Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate.

Allbritton NL, Meyer T, Stryer L. (1992) Science 258(5089):1812-5 [PubMed]

Inhibition of protein kinase C function by injection of intracellular receptors for the enzyme.

Smith BL, Mochly-Rosen D. (1992) Biochem. Biophys. Res. Commun. 188(3):1235-40 [PubMed]

Nicotinic acetylcholine receptor desensitization is regulated by activation-induced extracellular adenosine accumulation.

Pitchford S, Day JW, Gordon A, Mochly-Rosen D. (1992) J. Neurosci. 12(11):4540-4 [PubMed]

Inhibition of c-Jun DNA binding by mitogen-activated protein kinase.

Chou SY, Baichwal V, Ferrell JE. (1992) Mol. Biol. Cell 3(10):1117-30 [PubMed]

p65 fragments, homologous to the C2 region of protein kinase C, bind to the intracellular receptors for protein kinase C.

Mochly-Rosen D, Miller KG, Scheller RH, Khaner H, Lopez J, Smith BL. (1992) Biochemistry 31(35):8120-4 [PubMed]

Alcoholism: a possible G protein disorder.

Gordon AS, MOCHLY-ROSEN D, Diamond I. In G proteins, signal transduction and disease. Milligan G, Wakelam MJO (eds). Academic Press, Ltd., London, pp 191-216, 1992.

Decoding calcium signals by multifunctional CaM kinase.

Schulman H, Hanson PI, Meyer T. (1992) Cell Calcium 13(6-7):401-11 [PubMed]

Calmodulin trapping by calcium-calmodulin-dependent protein kinase.

Meyer T, Hanson PI, Stryer L, Schulman H. (1992) Science 256(5060):1199-202 [PubMed]

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity.

Liu J, Albers MW, Wandless TJ, Luan S, Alberg DG, Belshaw PJ, Cohen P, MacKintosh C, Klee CB, Schreiber SL. (1992) Biochemistry 31(16):3896-901 [PubMed]

Association of the beta isoform of protein kinase C with vimentin filaments.

Spudich A, Meyer T, Stryer L. (1992) Cell Motil. Cytoskeleton 22(4):250-6 [PubMed]

Immunophilin-ligand complexes as probes of intracellular signaling pathways.

Schreiber SL, Liu J, Albers MW, Karmacharya R, Koh E, Martin PK, Rosen MK, Standaert RF, Wandless TJ. (1991) Transplant. Proc. 23(6):2839-44 [PubMed]

Intracellular receptors for activated protein kinase C. Identification of a binding site for the enzyme.

Mochly-Rosen D, Khaner H, Lopez J, Smith BL. (1991) J. Biol. Chem. 266(23):14866-8 [PubMed]

Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin.

Michnick SW, Rosen MK, Wandless TJ, Karplus M, Schreiber SL. (1991) Science 252(5007):836-9 [PubMed]

Identification of intracellular receptor proteins for activated protein kinase C.

Mochly-Rosen D, Khaner H, Lopez J. (1991) Proc. Natl. Acad. Sci. U.S.A. 88(9):3997-4000 [PubMed]

Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs.

Ferrell JE, Wu M, Gerhart JC, Martin GS. (1991) Mol. Cell. Biol. 11(4):1965-71 [PubMed]

The identification and purification of a mammalian-like protein kinase C in the yeast Saccharomyces cerevisiae.

Simon AJ, Milner Y, Saville SP, Dvir A, Mochly-Rosen D, Orr E. (1991) Proc. Biol. Sci. 243(1307):165-71 [PubMed]

Cell signaling by second messenger waves.

Meyer T. (1991) Cell 64(4):675-8 [PubMed]

Assessing activities of blotted protein kinases.

Ferrell JE, Martin GS. (1991) Meth. Enzymol. 200:430-5 [PubMed]

G protein and alcoholism.

Gordon AS, Mochly-Rosen D, Diamond I. In Dysfunction of G-protein linked cascades in cellular pathology. Milligan G and Wakelam MJO (eds). Academic Press, 1991.

The role of adenosine and adenosine transport in ethanol-induced cellular tolerance and dependence. Possible biologic and genetic markers of alcoholism.

Diamond I, Nagy L, Mochly-Rosen D, Gordon A. (1991) Ann. N. Y. Acad. Sci. 625:473-87 [PubMed]

Calcium spiking.

Meyer T, Stryer L. (1991) Annu Rev Biophys Biophys Chem 20:153-74 [PubMed]

GTP-binding proteins are restricted to signal transduction sites.

Mochly-Rosen D, Gordon AS. (1990) Biochem. Biophys. Res. Commun. 173(1):388-95 [PubMed]

Probing immunosuppressant action with a nonnatural immunophilin ligand.

Bierer BE, Somers PK, Wandless TJ, Burakoff SJ, Schreiber SL. (1990) Science 250(4980):556-9 [PubMed]

Reduced adenosine receptor activation in alcoholism: implications for alcohol withdrawal seizures.

Diamond I, Mochly-Rosen D, Gordon AS. In Alcohol and seizures: basic mechanisms and clinical concepts. Porter R, Mattson R, Kramer J and Diamond I (eds). FA Davis, Philadelphia, pp 79-86, 1990.

A protein kinase C isozyme is translocated to cytoskeletal elements on activation.

Mochly-Rosen D, Henrich CJ, Cheever L, Khaner H, Simpson PC. (1990) Cell Regul. 1(9):693-706 [PubMed]

Intracellular localization of pp60c-src in human platelets.

Ferrell JE, Noble JA, Martin GS, Jacques YV, Bainton DF. (1990) Oncogene 5(7):1033-6 [PubMed]

Identification of a 42-kilodalton phosphotyrosyl protein as a serine(threonine) protein kinase by renaturation.

Ferrell JE, Martin GS. (1990) Mol. Cell. Biol. 10(6):3020-6 [PubMed]

Transient calcium release induced by successive increments of inositol 1,4,5-trisphosphate.

Meyer T, Stryer L. (1990) Proc. Natl. Acad. Sci. U.S.A. 87(10):3841-5 [PubMed]

Kinetics of calcium channel opening by inositol 1,4,5-trisphosphate.

Meyer T, Wensel T, Stryer L. (1990) Biochemistry 29(1):32-7 [PubMed]

Chronic ethanol-induced heterologous desensitization is mediated by changes in adenosine transport.

Gordon AS, Nagy L, Mochly-Rosen D, Diamond I. (1990) Biochem. Soc. Symp. 56:117-36 [PubMed]