The PharmGKB is a pharmacogenomics knowledge resource that encompasses clinical information including dosing guidelines and drug labels, potentially clinically actionable gene-drug associations, and genotype-phenotype relationships.
Description of Services
PharmGKB collects, curates, and disseminates knowledge about the impact of human genetic variation on drug responses through the following activities:
- Annotate genetic variants and gene-drug-disease relationships via literature reviews
- Summarize important pharmacogenomic genes, associations between genetic variants and drugs, and drug pathways
- Curate FDA drug labels containing pharmacogenomic information
- Enable consortia examining important questions in pharmacogenomics
- Curate and participate in writing pharmacogenomic-based drug dosing guidelines
- Contribute to clinical implementation projects for pharmacogenomics through collaborations
- Publish pharmacogenomic-based drug dosing guidelines, very important pharmacogene summaries, and drug-centered pathways
- Display all information on the website and provide comprehensive downloads
Selected References
Pharmacogenomics Knowledge for Personalized Medicine. M. Whirl-Carrillo, E.M. McDonagh, J. M. Hebert, L. Gong, K. Sangkuhl, C.F. Thorn, R.B. Altman and T.E. Klein.Clinical Pharmacology & Therapeutics (2012) 92(4): 414-417. PMID: 22992668;
From pharmacogenomic knowledge acquisition to clinical applications: the PharmGKB as a clinical pharmacogenomic biomarker resource. McDonagh EM, Whirl-Carrillo M, Garten Y, Altman RB and Klein TE. Biomarkers in Medicine (2011) Dec; 5(6):795-806. PubMedID: 22103613.
CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network. Clinical pharmacology and therapeutics. 2011. Relling MV, Klein TE. PubMedID: 21270786; PMCID: PMC3098762.
