Genetics and Sports
Editor(s): Posthumus, M. (Cape Town)Collins, M. (Cape Town)
The Future of Genomic Research in Athletic Performance and Adaptation to TrainingWang G.a · Tanaka M.d · Eynon N.f · North K.N.g · Williams A.G.b · Collins M.h · Moran C.N.c · Britton S.L.i · Fuku N.e · Ashley E.A.j · Klissouras V.k · Lucia A.l · Ahmetov I.I.m · de Geus E.n · Alsayrafi M.o · Pitsiladis Y.P.aaFIMS Reference Collaborating Centre of Sports Medicine for Anti-Doping Research, University of Brighton, Eastbourne, bDepartment of Exercise and Sport Science, Manchester Metropolitan University, Crewe, and cHealth and Exercise Sciences Research Group, University of Stirling, Stirling, UK; dDepartment of Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, and eGraduate School of Health and Sports Science, Juntendo University, Chiba, Japan; fInstitute of Sport, Exercise and Active Living (ISEAL), Victoria University, and gMurdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Vic., Australia; hDivision of Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; iDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, Mich., and jStanford University Medical Center, Stanford, Calif., USA; kErgophysiology Research Laboratory, Department of Sport Medicine and Biology of Physical Activity, University of Athens, Athens, Greece; lSchool of Doctorate Studies and Research, Universidad Europea de Madrid, Madrid, Spain; mSport Technology Research Center, Volga Region State Academy of Physical Culture, Sport and Tourism, Kazan, Russia; nVU University and VU Medical Centre, Amsterdam, The Netherlands; oAnti-Doping Lab Qatar (ADLQ), Doha, Qatar
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Posthumus M, Collins M (eds): Genetics and Sports, ed 2, revised, extended. Med Sport Sci. Basel, Karger, 2016, vol 61, pp 55-67
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Article / Publication Details
First-Page Preview
Published online: June 10, 2016
Cover Date: 2016
Number of Print Pages: 13
Number of Figures: 0
Number of Tables: 0
ISBN: 978-3-318-03010-5 (Print)
eISBN: 978-3-318-03011-2 (Online)
Abstract
Despite numerous attempts to discover genetic variants associated with elite athletic performance, an individual's trainability and injury predisposition, there has been limited progress to date. Past reliance on candidate gene studies focusing predominantly on genotyping a limited number of genetic variants in small, often heterogeneous cohorts has not generated results of practical significance. Hypothesis-free genome-wide approaches will in the future provide more comprehensive coverage and in-depth understanding of the biology underlying sports-related traits and related genetic mechanisms. Large, collaborative projects with sound experimental designs (e.g. clearly defined phenotypes, considerations and controls for sources of variability, and necessary replications) are required to produce meaningful results, especially when a hypothesis-free approach is used. It remains to be determined whether the novel approaches under current implementation will result in findings with real practical significance. This review will briefly summarize current and future directions in exercise genetics and genomics.
© 2016 S. Karger AG, Basel
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Article / Publication Details
First-Page Preview
Published online: June 10, 2016
Cover Date: 2016
Number of Print Pages: 13
Number of Figures: 0
Number of Tables: 0
ISBN: 978-3-318-03010-5 (Print)
eISBN: 978-3-318-03011-2 (Online)
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