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Ciliate Sheds Light on Ciliary Shedding

March 12, 2020

Ciliate Sheds Light on Ciliary Shedding

Delphine Gogendeau, France Koll, Anne-Marie Tassin and colleagues use functional analysis and subcellular localisation of conserved transition zone proteins in the ciliate Paramecium tetraurelia to reveal their involvement in the ciliary shedding process, opening new avenues for understanding the molecular mechanism of deciliation.


Image credit: pbio.3000640

PLOS Biologue

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PLOS Biologue

03/12/2020

Research Article

Nucleating Dendritic Microtubules

Alexis Weiner, Melissa Rolls and colleagues show that an atypical variant of canonical Wnt signaling controls microtubule nucleation from endosomes; although most canonical proteins are involved, this pathway is used to localize nucleation sites to dendrites rather than to regulate transcription. A related study by Derek Nye, Richard Albertson, Melissa Rolls and co-workers identifies the receptor tyrosine kinase Ror as a player in this process.

Image credit: pbio.3000647

Nucleating Dendritic Microtubules

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03/12/2020

Research Article

Hero Proteins Help Fight the Heat

Kotaro Tsuboyama, Yukihide Tomari and co-authors show that a family of proteins that remain soluble after heating to 95ºC (“heat-resistant obscure" or Hero proteins) are widespread in flies and humans, serving to stabilize various client proteins and block their aggregation.

Image credit: Wikimedia Commons user Scott Cameron

Hero Proteins Help Fight the Heat

03/12/2020

Research Article

Why Do Obese Mothers Have Obese Offspring?

Maternal obesity predisposes offspring to develop obesity and type 2 diabetes in later life, but the mechanisms are unclear. Soyoung Park, Alice Jang and Sebastien Bouret show that the metabolic and hypothalamic defects associated with maternal obesity involve high levels of endoplasmic reticulum stress during critical periods of growth and development.


Image credit: pbio.3000296

Why Do Obese Mothers Have Obese Offspring?

03/10/2020

Research Article

Learning to Use Meiotic Machinery for Mitosis

How do cells adapt when a protein is asked to participate in a different biological function? Yu-Ying Phoebe Hsieh, Vasso Makrantoni, Daniel Robertson, Adèle Marston and Andrew Murray show that experimental evolution allows budding yeast to use the meiotic cohesin protein Rec8 in mitosis via mutations in proteins other than Rec8 itself.

Learning to Use Meiotic Machinery for Mitosis

Image credit: pbio.3000635

03/10/2020

Research Article

Evolutionary Processes in Gut Bacteria

Ricardo Ramiro, Paulo Durão, Claudia Bank and Isabel Gordo show that weak-effect deleterious mutations and negative frequency-dependent selection acting on beneficial mutations shape the dynamics of molecular evolution within the mouse gut microbiota.



Evolutionary Processes in Gut Bacteria

Image credit: pbio.3000617

03/09/2020

Research Article

Rescuing Membrane Proteins from the Trash

Internalized transmembrane proteins can be recognized by specific protein complexes and diverted away from the degradation process. Xin Yong, Lin Zhao, Wankun Deng, Hongbin Sun, Xue Zhou, Da Jia and co-workers identify a new sorting motif recognized by retromer-linked SNX-BAR proteins and reveals a large repertoire of potential cargoes recycled by the SNX-BAR proteins.


Rescuing Membrane Proteins from the Trash

Image credit: pbio.3000631

03/09/2020

Research Article

Making the Spinal Cord Central Canal

The lumen of the developing vertebrate spinal cord is remodelled into the central canal by delamination of progenitor cells; This study shows that dorsal midline glia secrete a factor that regulates local delamination and ratcheting.

Making the Spinal Cord Central Canal

Image credit: pbio.3000470

03/05/2020

Research Article

Getting Used Histones into the Waste Disposal.

Cryo-EM structures of PA200 and the PA200-20S proteasome complex reveal two openings on PA200 which bind inositol phosphates as co-factors, yielding novel insights into PA200-induced gate-opening of 20S.

Getting Used Histones into the Waste Disposal.

Image credit: pbio.3000654

03/05/2020

Research Article

Sex, Heat and the Genetics of Lifespan

Effects of alleles associated with naturally occurring variation for lifespan in fruit flies are different in males and females and in different environments. This may explain the maintenance of variation of lifespan in nature.


Sex, Heat and the Genetics of Lifespan

Image credit: Carnegie Institution of Washington

03/05/2020

Research Article

How Likely is it? That Depends...

This study shows how probability estimation can be affected by the context of our recent experience, namely, how the presence of multiple events experienced closed in time can influence their respective probability estimates.

How Likely is it? That Depends...

Image credit: pbio.3000634

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