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Levy’s Rule

Levy’s Rule

Levy’s Rule to convert from oral morphine to transdermal fentanyl
The fentanyl patch strength in micrograms is equal to half of the total dose of sustained release morphine given over 24 hours.
Source: Levy M. Pharmacologic treatment of cancer pain. N Engl J Med 1996;335:1124-32.
  1. Levy’s Rule: Example 1 – Mr. John Smith, a terminally ill, lung cancer patient.
  2. Levy’s Rule: Example 2 – Mr. Tom Hack, a terminally ill, colon cancer patient.

 
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