Bio

Plants have an extraordinary capacity to harvest atmospheric CO2 and sunlight for the production of energy-rich biopolymers, clinically used drugs, and other biologically active small molecules. The metabolic pathways that produce these compounds are key to developing sustainable biofuel feedstocks, protecting crops from pathogens, and discovering new natural-product based therapeutics for human disease. These applications motivate us to find new ways to elucidate and engineer plant metabolism. We use a multidisciplinary approach combining chemistry, enzymology, genetics, and metabolomics to tackle problems that include new methods for delignification of lignocellulosic biomass and the engineering of plant antibiotic biosynthesis.

Academic Appointments

Honors & Awards

  • Terman Fellow, Stanford University (2011)
  • Pathway to Independence Award, NIH (2010)
  • Postdoctoral Fellowship, Damon Runyon Cancer Research Foundation (2008)
  • Division of Organic Chemistry Graduate Fellowship, ACS (2003)

Professional Education

  • PhD, Boston College (2007)

Contact

2015-16 Courses

Stanford Advisees

All Publications

  • Three Cytochromes P450 are Sufficient to Reconstitute the Biosynthesis of Camalexin, a Major Arabidopsis Antibiotic Angew. Chem. Int. Ed. Klein, A., P., Anarat-Cappillino, G., Sattely, E., S. 2013; 52: 13625-13628
  • Design and Stereoselective Preparation of a New Class of Chiral Olefin Metathesis Catalysts and Application to Enantioselective Synthesis of Quebrachamine: Catalyst Development Inspired by Natural Product Synthesis J. Am. Chem. Soc. Sattely, E., S., Meek, S., J., Malcolmson, S., J., Schrock, R., R., Hoveyda, A., H. 2009; 131: 943- 953
  • Three Siderophores from One Assembly Line Enzyme J. Am. Chem. Soc. Wuest, W., M., Sattely, E., S., Walsh, C., T. 2009; 131: 5056-5057
  • Enzymatic Tailoring of Ornithine in the Biosynthesis of the Rhizobium Cyclic Trihydroxamate Siderophore Vicibactin J. Am. Chem. Soc. Heemstra Jr., J., R., Walsh, C., T., Sattely, E., S. 2009; 131: 15317-15329
  • A Latent Oxazoline Electrophile for N-O-C Bond Formation in Pseudomonine Biosynthesis J. Am. Chem. Soc. Sattely, E., S., Walsh, C., T. 2008; 130: 12282-12284
  • Total Biosynthesis: in vitro Reconstitution of Polyketide and Nonribosomal Peptide Pathways Nat. Prod. Rep. Sattely, E., S., Fischbach, M., A., Walsh, C., T. 2008; 25: 757-793
  • Highly Efficient Molybdenum-Based Catalysts for Enantioselective Alkene Metathesis Nature Malcolmson, S., J., Meek, S., J., Sattely, E., S., Schrock, R., R., Hoveyda, A., H. 2008; 456: 933-937
  • Enantioselective Synthesis of Cyclic Amines and Amides through Mo-Catalyzed Asymmetric Ring-Closing Metathesis J. Am. Chem. Soc. Sattely, E., S., Cortez, G., A., Moebius, D., C., Schrock, R., R., Hoveyda, A., H. 2005; 127: 8526-8533
  • Efficient Catalytic Enantioselective Synthesis of Unsaturated Amines: Preparation of Small- and Medium- Ring Cyclic Amines through Mo-Catalyzed Asymmetric Ring-Closing Metathesis in the Absence of Solvent J. Am. Chem. Soc. Dolman, S., J., Sattely, E., S., Hoveyda, A., H., Schrock, R., R. 2002; 124: 6991-6997
  • Catalytic Asymmetric Ring-Opening Metathesis/Cross Metathesis (AROM/CM) Reactions. Mechanism and Application to Enantioselective Synthesis of Functionalized Cyclopentanes J. Am. Chem. Soc. La, D., S., Sattely, E., S., Ford, J., G., Schrock, R., R., Hoveyda, A., H. 2001; 123: 7767-7778
  • Tandem Catalytic Asymmetric Ring-Opening Metathesis/Cross Metathesis J. Am. Chem. Soc. La, D., S., Ford, J., G., Sattely, E., S., Bonitatebus, P., J., Schrock, R., R., Hoveyda, A., H. 1999; 121: 11603-11604