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Abstract
Breast cancer survivors experience diminished health-related quality of life (HRQOL). We report on the influence of tai chi chuan exercise (TCC) on HRQOL and explore associations between changes in HRQOL and biomarkers.Breast cancer survivors (N?=?21) were randomly assigned to TCC or standard support therapy (SST) for 12 weeks (three times/week; 60 min/session). Interleukin-6, interleukin-8 (IL-8), insulin-like growth factor-1 (IGF-1), insulin-like growth factor-binding protein (IBFBP)-1, IGFBP-3, glucose, insulin, and cortisol were measured pre- and postintervention. Overall HRQOL and subdomains were assessed at preintervention (T1), midintervention (T2) and postintervention (T3) and biomarkers at T1 and T3.The TCC group improved in total HRQOL (T1-T2:CS?=?8.54, P?=?0.045), physical functioning (T1-T2:CS?=?1.89, P?=?0.030), physical role limitations (T1-T2 CS?=?1.55, P?=?0.023), social functioning (T1-T3:CS?=?1.50, P?=?0.020), and general mental health (T1-T2:CS?=?2.67, P?=?0.014; T1-T3:CS?=?2.44, P?=?0.019). The SST improved in social functioning (T1-T2:CS?=?0.64, P?=?0.043) and vitality (T1-T2:CS?=?0.90, P?=?0.01). There were relationships between changes in IGF-1 and overall HRQOL (r?=?-0.56; P?
View details for DOI 10.1007/s11764-011-0205-7
View details for Web of Science ID 000302419700002
View details for PubMedID 22160628