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Phase I Trial of Arsenic Trioxide and Stereotactic Radiotherapy for Recurrent Malignant Glioma
To investigate the safety of delivering arsenic trioxide (ATO) in combination with
stereotactic radiotherapy in recurrent malignant glioma by performing an open label, Phase I
dose escalation trial. Results from this study will provide a basis for further study of ATO
combined with radiation therapy as a radiosensitizer for malignant brain tumors in future
Phase II studies.
Principal Investigator
- Iris C. Gibbs, MD, FACR
Stanford Investigator(s)
- Paul Graham Fisher, MD
- Susan Pillsbury
- Griffith Harsh, MD
- Lawrence Recht, MD
- Huy M. Do, MD