Different DR methods. (A) Table summarizing genes that have been tested for specific DR methods. Question marks indicate conflicting reports in the literature. sDR, ‘solid DR’ (); eat-2 (); bDR, liquid DR (; ); lDR, Liquid DR (); DD, dietary deprivation (; ); AM, axenic medium (; ); DP, dilution of peptone in plates (); CDLM, chemically defined liquid media (). D, dependent; PD, partially dependent; I, independent; ND, not determined. *Not a null mutant, making results more difficult to interpret. **Experiments were performed with RNAi, making results more difficult to interpret. let-363: C. elegans TOR gene mutant (; ). [1]: (), [2]: (), [3]: (), [4]: (), [5]: (), [6]: (), [7]: (), [8]: () [9]: (), [10]: (), [11]: (), [12]: (), [13]: (), [14]: (), [15]: (), [16]: (), [17]: (), [18]: ().(B) Different methods of DR activate distinct signaling pathways. Displayed are molecules that have been shown to play a role in mediating the longevity extension effects of DR methods. Question marks indicate conflicting reports (; ; ). LET-363: C. elegans TOR protein.