Immunohistologic staining for chemokine receptor 1 (CCR1) protein expression in human hematolymphoid neoplasia. Representative examples of CCR1 immunostaining in human lymphomas and leukemia are shown. CCR1 is expressed in cases of diffuse large B-cell lymphoma (A, ×400) and follicular lymphoma (C, ×40), with negative examples provided for comparison (B, ×400; D, ×40). In follicular lymphoma, CCR1 expression is present on the neoplastic cells (C, inset, ×400).
While CCR1 expression was present in cases of classical Hodgkin lymphoma (G, ×400), expression was largely absent in cases of extranodal marginal zone lymphoma (F, ×400), small lymphocytic lymphoma/chronic lymphocytic leukemia (E, ×400), and nodular lymphocyte predominant Hodgkin lymphoma (H, ×400). CCR1 was expressed by T-cell lymphomas, including peripheral T-cell lymphoma, not otherwise specified (I, ×400) and anaplastic large cell lymphoma (J, ×400). CCR1 expression was present in a majority of cases of multiple myeloma (K, ×400) and acute myeloid leukemia (L, ×400).