Under the ‘Pharmacogenomics (PGx) Research’ tab on a drug page, a list of variants with associations with the drug can be found. On gene pages, a similar format is found, with a list of variants within that gene and the drugs they have been associated with. If curated Variant Annotations and Clinical Annotations are available for the variant, this is represented by an icon in the first column of the table (). If the variant is described in a Very Important Pharmacogene (VIP) summary of the gene, this symbol is also provided (). As well as the reference single nucleotide polymorphisms identification (rsID), alternative names for the variant are provided. Useful information includes the variant alleles, the amino acid change (if applicable) and the features of the variant (e.g., a missense amino acid change). Alleles, Function and Amino Acid Translation are all sourced from single nucleotide polymorphisms database build 132 [].
Reprinted with permission from PharmGKB.