Mol Cell. 2015 Aug 20;59(4):515-6. doi: 10.1016/j.molcel.2015.08.004.

Shockingly Early: Chromatin-Mediated Loss of the Heat Shock Response.

Author information

1: Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA.
2: Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA; Glenn Laboratories for the Biology of Aging, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA. Electronic address: abrunet1@stanford.edu.

Abstract

In this issue of Molecular Cell, Labbadia and Morimoto (2015) show that there is a precipitous decline in stress resistance at the onset of reproduction in C. elegans and that this transition is regulated by changes in repressive chromatin marks.