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Clin Neurophysiol. 2017 Jan;128(1):128-137. doi: 10.1016/j.clinph.2016.10.095. Epub 2016 Nov 10.

Subthalamic oscillations and phase amplitude coupling are greater in the more affected hemisphere in Parkinson's disease.

Shreve LA1, Velisar A1, Malekmohammadi M1, Koop MM1, Trager M1, Quinn EJ1, Hill BC1, Blumenfeld Z1, Kilbane C2, Mantovani A3, Henderson JM2, Brontë-Stewart H4.

Author information

1
Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
2
Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA; Department of Neurosurgery, Stanford University, Stanford, CA, USA.
3
Department of Neurosurgery, Stanford University, Stanford, CA, USA.
4
Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA; Department of Neurosurgery, Stanford University, Stanford, CA, USA. Electronic address: hbs@stanford.edu.

Abstract

OBJECTIVE:

Determine the incidence of resting state oscillations in alpha/beta, high frequency (HFO) bands, and their phase amplitude coupling (PAC) in a large cohort in Parkinson's disease (PD).

METHODS:

Intra-operative local field potentials (LFPs) from subthalamic nucleus (STN) were recorded from 100 PD subjects, data from 74 subjects were included in the analysis.

RESULTS:

Alpha/beta oscillations were evident in >99%, HFO in 87% and PAC in 98% of cases. Alpha/beta oscillations (P<0.01) and PAC were stronger in the more affected (MA) hemisphere (P=0.03). Alpha/beta oscillations were primarily found in 13-20Hz (low beta). Beta and HFO frequencies with the greatest coupling, were positively correlated (P=0.001). Tremor attenuated alpha (P=0.002) and beta band oscillations (P<0.001).

CONCLUSIONS:

STN alpha/beta band oscillations and PAC were evident in ⩾98% cases and were greater in MA hemisphere. Resting tremor attenuated underlying alpha/beta band oscillations.

SIGNIFICANCE:

Beta band LFP power may be used to drive adaptive deep brain stimulation (aDBS), augmented by a kinematic classifier in tremor dominant PD.

Copyright © 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Beta oscillations; Deep brain stimulation; Parkinson’s disease; Phase amplitude coupling; Phenotypes; Tremor

PMID:
27889627
DOI:
10.1016/j.clinph.2016.10.095
[Indexed for MEDLINE]

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